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Gene Review

TRIP11  -  thyroid hormone receptor interactor 11

Homo sapiens

Synonyms: ACG1A, CEV14, Clonal evolution-related gene on chromosome 14 protein, GMAP-210, Golgi-associated microtubule-binding protein 210, ...
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Disease relevance of TRIP11


High impact information on TRIP11


Biological context of TRIP11


Anatomical context of TRIP11

  • Biochemical analysis further suggests that GMAP-210 specifically binds to microtubule ends [5].
  • The protein uses two distinct regions to bind Rb and thyroid hormone receptor (TR), respectively, and thus was named Trip230 [8].

Associations of TRIP11 with chemical compounds


Regulatory relationships of TRIP11


Other interactions of TRIP11


Analytical, diagnostic and therapeutic context of TRIP11

  • Within an hour of treating cells with T3, Trip230 immunofluorescence transiently colocalized with TR in prominent subnuclear structures [3].


  1. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. Abe, A., Emi, N., Tanimoto, M., Terasaki, H., Marunouchi, T., Saito, H. Blood (1997) [Pubmed]
  2. The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus. Pernet-Gallay, K., Antony, C., Johannes, L., Bornens, M., Goud, B., Rios, R.M. Traffic (2002) [Pubmed]
  3. Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus. Chen, Y., Chen, P.L., Chen, C.F., Sharp, Z.D., Lee, W.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. GMAP-210 recruits gamma-tubulin complexes to cis-Golgi membranes and is required for Golgi ribbon formation. Ríos, R.M., Sanchís, A., Tassin, A.M., Fedriani, C., Bornens, M. Cell (2004) [Pubmed]
  5. GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein. Infante, C., Ramos-Morales, F., Fedriani, C., Bornens, M., Rios, R.M. J. Cell Biol. (1999) [Pubmed]
  6. Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. Beischlag, T.V., Taylor, R.T., Rose, D.W., Yoon, D., Chen, Y., Lee, W.H., Rosenfeld, M.G., Hankinson, O. J. Biol. Chem. (2004) [Pubmed]
  7. Two splice variants of Golgi-microtubule-associated protein of 210 kDa (GMAP-210) differ in their binding to the cis-Golgi network. Ramos-Morales, F., Vime, C., Bornens, M., Fedriani, C., Rios, R.M. Biochem. J. (2001) [Pubmed]
  8. A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Chang, K.H., Chen, Y., Chen, T.T., Chou, W.H., Chen, P.L., Ma, Y.Y., Yang-Feng, T.L., Leng, X., Tsai, M.J., O'Malley, B.W., Lee, W.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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