The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

RPS16  -  ribosomal protein S16

Homo sapiens

Synonyms: 40S ribosomal protein S16, S16
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on RPS16

  • To clarify the origins of CAM and the epiphytic habit, we conducted a phylogenetic analysis of nucleotide sequences for 51 bromeliad taxa by using the plastid loci matK and the rps16 intron, combined with a survey of photosynthetic pathway determined by carbon-isotope ratios for 1,873 species representing 65% of the family [1].
  • The among-site rate variation was significantly lower in the RNA polymerase introns than in the rps16 intron and ITSs, a property that is attractive in phylogenetic analyses [2].
  • Southern blot analysis of genomic DNA showed a 20-fold amplification of a single band among the rpS16 family only in the Panc 1 cell line [3].
  • Sequence analysis of this cDNA clone and its deduced amino acid sequence showed an open reading frame of 441 nucleotides with 100 and 98.6% homology to ribosomal protein S16 (rpS16) from rat and mouse, respectively [3].
  • A 54 kDa protein from mustard chloroplasts was previously shown to interact specifically with a conserved U-rich sequence element in RNA derived from the 3' flanking regions of the plastid trnK and rps16 genes, which code for tRNA(Lys) and ribosomal protein CS19, respectively (Nickelsen and Link, 1991) [4].

Biological context of RPS16

  • The protein-binding region of the rps16 3' terminal region was mapped and compared with that of the trnK transcript determined previously [5].
  • A strongly supported phylogeny of the genus is estimated using combined sequence data from three chloroplast markers (matK, ndhF, and rps16) and two nuclear markers (ITS and waxy) [6].
  • The rps16 intron displayed low levels of variation, corroborating previous reports that the chloroplast genome of palms is highly conserved [7].
  • Three RNA 5' ends upstream of the rps16 coding region define both the transcription start site and two RNA processing sites [8].
  • The transcription start site of the psbK operon appears to overlap that of the rps16 gene [9].

Anatomical context of RPS16


Physical interactions of RPS16

  • RNase protection experiments indicate that the protein-binding regions of both the rps16 and trnK transcripts correlate with the positions of in vivo 3' ends, suggesting an essential role for the 54 kDa binding protein in RNA 3' end formation [5].

Other interactions of RPS16

  • The translational apparatus of Tortula ruralis: polysomal retention of transcripts encoding the ribosomal proteins RPS14, RPS16 and RPL23 in desiccated and rehydrated gametophytes [11].
  • RNA blot hybridizations of RNAs present within the polysomal mRNP fraction (i.e. the 100 Kxg pellet) demonstrated that Rps14, Rps16 and Rpl23 are expressed in moss gametophytes during a desiccation-rehydration cycle and, according to the prior cDNA classification scheme in T. ruralis, are constitutive clones [11].

Analytical, diagnostic and therapeutic context of RPS16


  1. Multiple origins of crassulacean acid metabolism and the epiphytic habit in the Neotropical family Bromeliaceae. Crayn, D.M., Winter, K., Smith, J.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Evolution of a RNA polymerase gene family in Silene (Caryophyllaceae)-incomplete concerted evolution and topological congruence among paralogues. Popp, M., Oxelman, B. Syst. Biol. (2004) [Pubmed]
  3. Molecular cloning and sequence analysis of the human ribosomal protein S16. Batra, S.K., Metzgar, R.S., Hollingsworth, M.A. J. Biol. Chem. (1991) [Pubmed]
  4. The 54 kDa RNA-binding protein from mustard chloroplasts mediates endonucleolytic transcript 3' end formation in vitro. Nickelsen, J., Link, G. Plant J. (1993) [Pubmed]
  5. RNA-protein interactions at transcript 3' ends and evidence for trnK-psbA cotranscription in mustard chloroplasts. Nickelsen, J., Link, G. Mol. Gen. Genet. (1991) [Pubmed]
  6. Molecular evidence for the age, origin, and evolutionary history of the American desert plant genus Tiquilia (Boraginaceae). Moore, M.J., Jansen, R.K. Mol. Phylogenet. Evol. (2006) [Pubmed]
  7. Molecular phylogenetics of subfamily Calamoideae (Palmae) based on nrDNA ITS and cpDNA rps16 intron sequence data. Baker, W.J., Hedderson, T.A., Dransfield, J. Mol. Phylogenet. Evol. (2000) [Pubmed]
  8. Structure and expression of a split chloroplast gene from mustard (Sinapis alba): ribosomal protein gene rps16 reveals unusual transcriptional features and complex RNA maturation. Neuhaus, H., Scholz, A., Link, G. Curr. Genet. (1989) [Pubmed]
  9. The chloroplast psbK operon from mustard (Sinapis alba L.): multiple transcripts during seedling development and evidence for divergent overlapping transcription. Neuhaus, H., Link, G. Curr. Genet. (1990) [Pubmed]
  10. Downregulation of long-form prolactin receptor mRNA during prolactin-induced luteal regression. Bowen, J.M., Telleria, C.M., Towns, R., Keyes, P.L. Eur. J. Endocrinol. (2000) [Pubmed]
  11. The translational apparatus of Tortula ruralis: polysomal retention of transcripts encoding the ribosomal proteins RPS14, RPS16 and RPL23 in desiccated and rehydrated gametophytes. Wood, A.J., Joel Duff, R., Oliver, M.J. J. Exp. Bot. (2000) [Pubmed]
WikiGenes - Universities