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Gene Review

LRP1B  -  low density lipoprotein receptor-related...

Homo sapiens

Synonyms: LRP-1B, LRP-DIT, LRPDIT, Low-density lipoprotein receptor-related protein 1B, Low-density lipoprotein receptor-related protein-deleted in tumor
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Disease relevance of LRP1B


Psychiatry related information on LRP1B


High impact information on LRP1B

  • Genomic PCR experiments revealed homozygous deletions of LRP1B in additional ESC cell lines (total, 6 of 43; 14.0%) and in primary esophageal tumors (30 of 70; 42.9%) [2].
  • Methylation of LRP1B was also detected in primary esophageal tumors [2].
  • These results suggest that loss of LRP1B function in esophageal carcinogenesis most often occurs either by homozygous deletion or by transcriptional silencing through hypermethylation of its CpG island [2].
  • Treatment with 5-aza-2'-deoxycytidine restored expression of LRP1B in those ESC lines [2].
  • Histone acetylation status correlated directly with expression of LRP1B and inversely with the methylation status of the CpG island [2].

Biological context of LRP1B


Anatomical context of LRP1B


Physical interactions of LRP1B

  • Cell surface and internalization assays, in combination with coimmunoprecipitation experiments, showed that LRP1B binds and internalizes uPAR [8].

Enzymatic interactions of LRP1B


Other interactions of LRP1B

  • The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein [4].
  • CONCLUSIONS: LRP1B modulates the catabolism of uPAR and PDGFR, affecting the migration of SMCs [8].


  1. The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. Cam, J.A., Zerbinatti, C.V., Knisely, J.M., Hecimovic, S., Li, Y., Bu, G. J. Biol. Chem. (2004) [Pubmed]
  2. Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma. Sonoda, I., Imoto, I., Inoue, J., Shibata, T., Shimada, Y., Chin, K., Imamura, M., Amagasa, T., Gray, J.W., Hirohashi, S., Inazawa, J. Cancer Res. (2004) [Pubmed]
  3. LRP 1 B functions as a receptor for Pseudomonas exotoxin. Pastrana, D.V., Hanson, A.J., Knisely, J., Bu, G., Fitzgerald, D.J. Biochim. Biophys. Acta (2005) [Pubmed]
  4. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. Liu, C.X., Li, Y., Obermoeller-McCormick, L.M., Schwartz, A.L., Bu, G. J. Biol. Chem. (2001) [Pubmed]
  5. Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration. Li, Y., Knisely, J.M., Lu, W., McCormick, L.M., Wang, J., Henkin, J., Schwartz, A.L., Bu, G. J. Biol. Chem. (2002) [Pubmed]
  6. Differential DNA methylation patterns of small B-cell lymphoma subclasses with different clinical behavior. Rahmatpanah, F.B., Carstens, S., Guo, J., Sjahputera, O., Taylor, K.H., Duff, D., Shi, H., Davis, J.W., Hooshmand, S.I., Chitma-Matsiga, R., Caldwell, C.W. Leukemia (2006) [Pubmed]
  7. Striking differences of LDL receptor-related protein 1B expression in mouse and human. Li, Y., Lu, W., Bu, G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors. Tanaga, K., Bujo, H., Zhu, Y., Kanaki, T., Hirayama, S., Takahashi, K., Inoue, M., Mikami, K., Schneider, W.J., Saito, Y. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
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