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Gene Review

CITED1  -  Cbp/p300-interacting transactivator, with...

Homo sapiens

Synonyms: Cbp/p300-interacting transactivator 1, MSG1, Melanocyte-specific protein 1
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Disease relevance of CITED1


High impact information on CITED1


Chemical compound and disease context of CITED1


Biological context of CITED1


Anatomical context of CITED1


Associations of CITED1 with chemical compounds


Physical interactions of CITED1

  • The C-terminal transactivating domain of MSG1 is required for binding to p300/CBP and enhancement of Smad-mediated transcription; the viral VP16 transactivating domain could not substitute for it [19].

Regulatory relationships of CITED1


Other interactions of CITED1


Analytical, diagnostic and therapeutic context of CITED1


  1. Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Prasad, M.L., Pellegata, N.S., Huang, Y., Nagaraja, H.N., de la Chapelle, A., Kloos, R.T. Mod. Pathol. (2005) [Pubmed]
  2. msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. Shioda, T., Fenner, M.H., Isselbacher, K.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo. Ahmed, N.U., Shioda, T., Coser, K.R., Ichihashi, M., Ueda, M. Pigment Cell Res. (2001) [Pubmed]
  4. CITED1 protein expression suggests Papillary Thyroid Carcinoma in high throughput tissue microarray-based study. Prasad, M.L., Pellegata, N.S., Kloos, R.T., Barbacioru, C., Huang, Y., de la Chapelle, A. Thyroid (2004) [Pubmed]
  5. An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions. Anichini, A., Molla, A., Mortarini, R., Tragni, G., Bersani, I., Di Nicola, M., Gianni, A.M., Pilotti, S., Dunbar, R., Cerundolo, V., Parmiani, G. J. Exp. Med. (1999) [Pubmed]
  6. High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo. Ogg, G.S., Rod Dunbar, P., Romero, P., Chen, J.L., Cerundolo, V. J. Exp. Med. (1998) [Pubmed]
  7. Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma. Kunter, U., Buer, J., Probst, M., Duensing, S., Dallmann, I., Grosse, J., Kirchner, H., Schluepen, E.M., Volkenandt, M., Ganser, A., Atzpodien, J. J. Natl. Cancer Inst. (1996) [Pubmed]
  8. Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment. Kulesa, P.M., Kasemeier-Kulesa, J.C., Teddy, J.M., Margaryan, N.V., Seftor, E.A., Seftor, R.E., Hendrix, M.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Huang, Y., Prasad, M., Lemon, W.J., Hampel, H., Wright, F.A., Kornacker, K., LiVolsi, V., Frankel, W., Kloos, R.T., Eng, C., Pellegata, N.S., de la Chapelle, A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  10. Identification of a secreted Mr 95,000 glycoprotein in human melanocytes and melanomas by a melanocyte specific monoclonal antibody. Vogel, A.M., Esclamado, R.M. Cancer Res. (1988) [Pubmed]
  11. The Transcriptional Activity of CITED1 Is Regulated by Phosphorylation in a Cell Cycle-dependent Manner. Shi, G., Boyle, S.C., Sparrow, D.B., Dunwoodie, S.L., Shioda, T., de Caestecker, M.P. J. Biol. Chem. (2006) [Pubmed]
  12. Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas. Vachtenheim, J., Novotná, H. Cell. Mol. Biol. (Noisy-le-grand) (1999) [Pubmed]
  13. Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Theos, A.C., Tenza, D., Martina, J.A., Hurbain, I., Peden, A.A., Sviderskaya, E.V., Stewart, A., Robinson, M.S., Bennett, D.C., Cutler, D.F., Bonifacino, J.S., Marks, M.S., Raposo, G. Mol. Biol. Cell (2005) [Pubmed]
  14. Altered protein localization in melanocytes from Hermansky-Pudlak syndrome: support for the role of the HPS gene product in intracellular trafficking. Boissy, R.E., Zhao, Y., Gahl, W.A. Lab. Invest. (1998) [Pubmed]
  15. Clinical relevance of molecular staging for melanoma: comparison of RT-PCR and immunohistochemistry staining in sentinel lymph nodes of patients with melanoma. Li, W., Stall, A., Shivers, S.C., Lin, J., Haddad, F., Messina, J., Glass, L.F., Lyman, G., Reintgen, D.S. Ann. Surg. (2000) [Pubmed]
  16. The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity. Yang, F., Sarangarajan, R., Le Poole, I.C., Medrano, E.E., Boissy, R.E. J. Invest. Dermatol. (2000) [Pubmed]
  17. After dopachrome? Pawelek, J.M. Pigment Cell Res. (1991) [Pubmed]
  18. TYRP2-mediated resistance to cis-diamminedichloroplatinum (II) in human melanoma cells is independent of tyrosinase and TYRP1 expression and melanin content. Pak, B.J., Li, Q., Kerbel, R.S., Ben-David, Y. Melanoma Res. (2000) [Pubmed]
  19. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. Yahata, T., de Caestecker, M.P., Lechleider, R.J., Andriole, S., Roberts, A.B., Isselbacher, K.J., Shioda, T. J. Biol. Chem. (2000) [Pubmed]
  20. Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells. Li, H., Ahmed, N.U., Fenner, M.H., Ueda, M., Isselbacher, K.J., Shioda, T. Exp. Cell Res. (1998) [Pubmed]
  21. Inhibition of MITF transcriptional activity independent of targeting p300/CBP coactivators. Vachtenheim, J., Sestáková, B., Tuhácková, Z. Pigment Cell Res. (2007) [Pubmed]
  22. Molecular and prognostic classification of advanced melanoma: a multi-marker microcontamination assay of peripheral blood stem cells. Schrader, A.J., Probst-Kepper, M., Grosse, J., Kunter, U., Schenk, F., Franzke, A., Atzpodien, J., Buer, J. Melanoma Res. (2000) [Pubmed]
  23. Diagnostic Usefulness of HBME1, Galectin-3, CK19, and CITED1 and Evaluation of Their Expression in Encapsulated Lesions With Questionable Features of Papillary Thyroid Carcinoma. Scognamiglio, T., Hyjek, E., Kao, J., Chen, Y.T. Am. J. Clin. Pathol. (2006) [Pubmed]
  24. Melanocyte-specific gene expression: role of repression and identification of a melanocyte-specific factor, MSF. Yavuzer, U., Goding, C.R. Mol. Cell. Biol. (1994) [Pubmed]
  25. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. Glenn, D.J., Maurer, R.A. J. Biol. Chem. (1999) [Pubmed]
  26. MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis. Fenner, M.H., Parrish, J.E., Boyd, Y., Reed, V., MacDonald, M., Nelson, D.L., Isselbacher, K.J., Shioda, T. Genomics (1998) [Pubmed]
  27. Detection of renovascular hypertension. State of the art: 1992. Mann, S.J., Pickering, T.G. Ann. Intern. Med. (1992) [Pubmed]
  28. Molecular test for the detection of tumor cells in blood and sentinel nodes of melanoma patients. Van der Velde-Zimmermann, D., Roijers, J.F., Bouwens-Rombouts, A., De Weger, R.A., De Graaf, P.W., Tilanus, M.G., Van den Tweel, J.G. Am. J. Pathol. (1996) [Pubmed]
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