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Gene Review

STOML1  -  stomatin (EPB72)-like 1

Homo sapiens

Synonyms: EPB72-like protein 1, FLJ36370, MSTP019, Protein unc-24 homolog, SLP-1, ...
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High impact information on STOML1


Biological context of STOML1


Anatomical context of STOML1


Associations of STOML1 with chemical compounds

  • We report here a study of strongly homologous stomatin-like genes in prokaryotes, which reveals a close connection with a never-studied gene erroneously known as "nfed." This gene codes for a hydrophobic protein with a probable serine protease motif [8].

Other interactions of STOML1

  • A cDNA encoding a novel second member of the Band7/stomatin-like/SPFH domain family in humans designated stomatin-like 2 (STOML2) has been isolated using the technique of cDNA Representational Difference Analysis [9].

Analytical, diagnostic and therapeutic context of STOML1


  1. MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Goodman, M.B., Ernstrom, G.G., Chelur, D.S., O'Hagan, R., Yao, C.A., Chalfie, M. Nature (2002) [Pubmed]
  2. Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view. Chevallet, M., Lescuyer, P., Diemer, H., van Dorsselaer, A., Leize-Wagner, E., Rabilloud, T. Electrophoresis (2006) [Pubmed]
  3. Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation. Johnson, J.L., Pacquelet, S., Lane, W.S., Eam, B., Catz, S.D. Traffic (2005) [Pubmed]
  4. Plasma membrane targeting of podocin through the classical exocytic pathway: effect of NPHS2 mutations. Roselli, S., Moutkine, I., Gribouval, O., Benmerah, A., Antignac, C. Traffic (2004) [Pubmed]
  5. Model organisms: new insights into ion channel and transporter function. Stomatin homologues interact in Caenorhabditis elegans. Sedensky, M.M., Siefker, J.M., Morgan, P.G. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  6. Molecular cloning of hSLP-1, a novel human brain-specific member of the band 7/MEC-2 family similar to Caenorhabditis elegans UNC-24. Seidel, G., Prohaska, R. Gene (1998) [Pubmed]
  7. A novel gene STORP (STOmatin-Related Protein) is localized 2 kb upstream of the promyelocytic gene on chromosome 15q22. Gilles, F., Glenn, M., Goy, A., Remache, Y., Zelenetz, A.D. Eur. J. Haematol. (2000) [Pubmed]
  8. Eukaryotic and prokaryotic stomatins: the proteolytic link. Green, J.B., Fricke, B., Chetty, M.C., von Düring, M., Preston, G.F., Stewart, G.W. Blood Cells Mol. Dis. (2004) [Pubmed]
  9. A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1. Owczarek, C.M., Treutlein, H.R., Portbury, K.J., Gulluyan, L.M., Kola, I., Hertzog, P.J. Cytogenet. Cell Genet. (2001) [Pubmed]
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