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Gene Review

Slc4a10  -  solute carrier family 4, sodium...

Mus musculus

Synonyms: Kiaa4136, NCBE, Ncbe, Sodium-driven chloride bicarbonate exchanger, Solute carrier family 4 member 10, ...
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Disease relevance of Slc4a10


High impact information on Slc4a10

  • Functional analyses of the NCBE protein expressed in Xenopus laevis oocytes and HEK293 cells demonstrate that it transports extracellular Na(+) and HCO(3)(-) into cells in exchange for intracellular Cl(-) and H(+), thus raising the intracellular pH [1].
  • We show here the primary structure, tissue distribution, and functional characterization of Na(+)-driven chloride/bicarbonate exchanger (designated NCBE) cloned from the insulin-secreting cell line MIN6 cDNA library [1].
  • The NCBE protein consists of 1088 amino acids having 74, 72, and 55% amino acid identity to the human skeletal muscle, rat smooth muscle, and human kidney sodium bicarbonate cotransporter, respectively [1].
  • The Cl(-)/HCO(3)(-) exchanger, AE2, was localized basolaterally, as was the Na(+)-dependent Cl(-)/HCO(3)(-) exchanger, NCBE, and the electroneutral Na(+)-HCO(3)(-) cotransporter, NBCn1 [2].
  • Here we identify two novel variants of the sodium-driven chloride bicarbonate exchanger (NCBE) from brain [3].

Anatomical context of Slc4a10


Associations of Slc4a10 with chemical compounds

  • As NCBE, a sodium-dependent chloride-bicarbonate exchanger, also lowers [Cl(-)](i) and may thus modulate the GABA-response, we analyzed its expression during prenatal mouse development before establishment of the mature KCC2 expression [4].

Regulatory relationships of Slc4a10

  • Indeed, NCBE is expressed very early in CNS neurons and precedes the expression of KCC2 [4].


  1. The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. Wang, C.Z., Yano, H., Nagashima, K., Seino, S. J. Biol. Chem. (2000) [Pubmed]
  2. Distribution of sodium transporters and aquaporin-1 in the human choroid plexus. Praetorius, J., Nielsen, S. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  3. Two variants of the rat brain sodium-driven chloride bicarbonate exchanger (NCBE): developmental expression and addition of a PDZ motif. Giffard, R.G., Lee, Y.S., Ouyang, Y.B., Murphy, S.L., Monyer, H. Eur. J. Neurosci. (2003) [Pubmed]
  4. Expression of the sodium-driven chloride bicarbonate exchanger NCBE during prenatal mouse development. Hübner, C.A., Hentschke, M., Jacobs, S., Hermans-Borgmeyer, I. Gene Expr. Patterns (2004) [Pubmed]
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