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Gene Review

PSY2  -  phytoene synthase

Solanum lycopersicum

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Disease relevance of PSY2

  • A plasmid containing the PSY2 coding region under control of a bacterial promoter complements a Rhodobacter capsulatus phytoene synthase mutant, indicating that this gene has the capacity to encode an active enzyme [1].
  • Phytoene synthase from the bacterium Erwinia uredovora (crtB) has been overexpressed in tomato (Lycopersicon esculentum Mill. cv. Ailsa Craig) [2].
  • The antigen was prepared as a beta-galactosidase fusion protein by cloning a 1.13 kb fragment of Psy1 cDNA into pUR291, followed by transformation of E. coli [3].

High impact information on PSY2


Biological context of PSY2


Anatomical context of PSY2


Associations of PSY2 with chemical compounds

  • 6. Although phytoene synthase was functional in a monomeric state, under optimal native conditions it was associated with a large (at least 200 kDa) protein complex which contained other terpenoid enzymes such as isopentenyl diphosphate isomerase and geranylgeranyl diphosphate (GGPP) synthase [8].

Analytical, diagnostic and therapeutic context of PSY2


  1. cDNA cloning, expression during development, and genome mapping of PSY2, a second tomato gene encoding phytoene synthase. Bartley, G.E., Scolnik, P.A. J. Biol. Chem. (1993) [Pubmed]
  2. Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner. Fraser, P.D., Romer, S., Shipton, C.A., Mills, P.B., Kiano, J.W., Misawa, N., Drake, R.G., Schuch, W., Bramley, P.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Production and characterisation of monoclonal antibodies to phytoene synthase of Lycopersicon esculentum. Fraser, P.D., Misawa, N., Sandmann, G., Johnson, J., Schuch, W., Bramley, P.M. Phytochemistry (1998) [Pubmed]
  4. Candidate gene analysis of organ pigmentation loci in the Solanaceae. Thorup, T.A., Tanyolac, B., Livingstone, K.D., Popovsky, S., Paran, I., Jahn, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. A tomato gene expressed during fruit ripening encodes an enzyme of the carotenoid biosynthesis pathway. Bartley, G.E., Viitanen, P.V., Bacot, K.O., Scolnik, P.A. J. Biol. Chem. (1992) [Pubmed]
  6. Why is golden rice golden (yellow) instead of red? Schaub, P., Al-Babili, S., Drake, R., Beyer, P. Plant Physiol. (2005) [Pubmed]
  7. Increases in cell elongation, plastid compartment size and phytoene synthase activity underlie the phenotype of the high pigment-1 mutant of tomato. Cookson, P.J., Kiano, J.W., Shipton, C.A., Fraser, P.D., Romer, S., Schuch, W., Bramley, P.M., Pyke, K.A. Planta (2003) [Pubmed]
  8. Phytoene synthase from tomato (Lycopersicon esculentum) chloroplasts--partial purification and biochemical properties. Fraser, P.D., Schuch, W., Bramley, P.M. Planta (2000) [Pubmed]
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