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Gene Review

ptsH  -  phosphohistidinoprotein-hexose...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2410, JW2408, ctr, hpr
 
 
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Disease relevance of ptsH

 

High impact information on ptsH

  • The ptsH operon of Escherichia coli is controlled by two promoters P0 and P1, each of which is regulated by cyclic AMP receptor protein (CRP) complexed with cAMP (CRP.cAMP) [3].
  • The nucleotide sequences of ptsH, ptsI, and crr and the corresponding flanking regions have been determined [4].
  • Growth on other PTS sugars, besides glucose, also induces ptsH and ptsG expression, suggesting that the target of Mlc regulation is the PTS [5].
  • Mutation of this 70-bp UTR and of the direct repeat upregulated both syn and ctr transcription [6].
  • In addition to CcpA, carbon catabolite activation of the pta gene therefore requires at least two other cofactors, FBP and either HPr or Crh, phosphorylated at Ser-46 by the ATP-dependent Hpr kinase [7].
 

Chemical compound and disease context of ptsH

 

Biological context of ptsH

 

Associations of ptsH with chemical compounds

  • The form resistant to the thiol reagent requires not only the absence of sugar and an intact phosphoenolpyruvate generating system, but also an intact system generating phosphorylated Hpr which is impaired by heating of a thermosensitive enzyme I mutant [12].
 

Analytical, diagnostic and therapeutic context of ptsH

References

  1. Analysis of the ptsH-ptsI-crr region in Escherichia coli K-12: nucleotide sequence of the ptsH gene. De Reuse, H., Roy, A., Danchin, A. Gene (1985) [Pubmed]
  2. The transition state regulator Hpr of Bacillus subtilis is a DNA-binding protein. Kallio, P.T., Fagelson, J.E., Hoch, J.A., Strauch, M.A. J. Biol. Chem. (1991) [Pubmed]
  3. Promoter switch in the Escherichia coli pts operon. Ryu, S., Garges, S. J. Biol. Chem. (1994) [Pubmed]
  4. Sugar transport by the bacterial phosphotransferase system. Molecular cloning and structural analysis of the Escherichia coli ptsH, ptsI, and crr genes. Saffen, D.W., Presper, K.A., Doering, T.L., Roseman, S. J. Biol. Chem. (1987) [Pubmed]
  5. Expression of the phosphotransferase system both mediates and is mediated by Mlc regulation in Escherichia coli. Plumbridge, J. Mol. Microbiol. (1999) [Pubmed]
  6. Transcriptional regulation of divergent capsule biosynthesis and transport operon promoters in serogroup B Neisseria meningitidis. Tzeng, Y.L., Swartley, J.S., Miller, Y.K., Nisbet, R.E., Liu, L.J., Ahn, J.H., Stephens, D.S. Infect. Immun. (2001) [Pubmed]
  7. Catabolite regulation of the pta gene as part of carbon flow pathways in Bacillus subtilis. Presecan-Siedel, E., Galinier, A., Longin, R., Deutscher, J., Danchin, A., Glaser, P., Martin-Verstraete, I. J. Bacteriol. (1999) [Pubmed]
  8. Mutants of Escherichia coli producing pyrroloquinoline quinone. Biville, F., Turlin, E., Gasser, F. J. Gen. Microbiol. (1991) [Pubmed]
  9. The HPr protein of the phosphotransferase system links induction and catabolite repression of the Bacillus subtilis levanase operon. Stülke, J., Martin-Verstraete, I., Charrier, V., Klier, A., Deutscher, J., Rapoport, G. J. Bacteriol. (1995) [Pubmed]
  10. Positive regulation of the pts operon of Escherichia coli: genetic evidence for a signal transduction mechanism. De Reuse, H., Danchin, A. J. Bacteriol. (1991) [Pubmed]
  11. Cold shock stress-induced proteins in Bacillus subtilis. Graumann, P., Schröder, K., Schmid, R., Marahiel, M.A. J. Bacteriol. (1996) [Pubmed]
  12. The role of enzyme I in the unmasking of an essential thiol of the membrane-bound enzyme II of the phosphoenolpyruvate-glucose phosphotransferase system of Escherichia coli. Haguenauer-Tsapis, R., Kepes, A. Biochim. Biophys. Acta (1977) [Pubmed]
 
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