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Gene Review

ECs4208  -  cAMP-regulatory protein

Escherichia coli O157:H7 str. Sakai

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Disease relevance of ECs4208


High impact information on ECs4208


Chemical compound and disease context of ECs4208


Biological context of ECs4208


Anatomical context of ECs4208


Associations of ECs4208 with chemical compounds

  • We show that glucose lowers the level of crp mRNA without affecting its stability [11].
  • The structure of complexes formed between cAMP receptor protein (CRP) and various restriction fragments from the promoter region of the lactose operon has been analysed by measurements of electrodichroism [23].
  • We have used random mutagenesis and alanine scanning to identify determinants within alphaCTD for transcription activation at a Class II CRP-dependent promoter [24].
  • A very high concentration of heparin is able to dissociate CRP from the galP1 ternary complex without changing the properties of the complex [25].
  • Adenylate cyclase deficient cells harbouring the mutant (crp*) plasmids exhibited a variety of fermentation profiles on MacConkey indicator plates containing various sugars. beta-galactosidase synthesis in cells carrying the crp* plasmids was activated most by the addition of cGMP as well as cAMP [17].

Other interactions of ECs4208


Analytical, diagnostic and therapeutic context of ECs4208


  1. Autoregulation of the Escherichia coli crp gene: CRP is a transcriptional repressor for its own gene. Aiba, H. Cell (1983) [Pubmed]
  2. The gene encoding cAMP receptor protein is required for competence development in Haemophilus influenzae Rd. Chandler, M.S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Identification and characterization of a novel cAMP receptor protein in the cyanobacterium Synechocystis sp. PCC 6803. Yoshimura, H., Hisabori, T., Yanagisawa, S., Ohmori, M. J. Biol. Chem. (2000) [Pubmed]
  4. Transcription activation by CooA, the CO-sensing factor from Rhodospirillum rubrum. The interaction between CooA and the C-terminal domain of the alpha subunit of RNA polymerase. He, Y., Gaal, T., Karls, R., Donohue, T.J., Gourse, R.L., Roberts, G.P. J. Biol. Chem. (1999) [Pubmed]
  5. Sensitization of the Escherichia coli cyclic AMP receptor protein to trypsin cleavage by polydeoxyribonucleotides and polyribonucleotides. Angulo, J., Krakow, J.S. J. Biol. Chem. (1986) [Pubmed]
  6. A new mechanism for coactivation of transcription initiation: repositioning of an activator triggered by the binding of a second activator. Richet, E., Vidal-Ingigliardi, D., Raibaud, O. Cell (1991) [Pubmed]
  7. CAP interacts with RNA polymerase in solution in the absence of promoter DNA. Heyduk, T., Lee, J.C., Ebright, Y.W., Blatter, E.E., Zhou, Y., Ebright, R.H. Nature (1993) [Pubmed]
  8. A whole genome approach to in vivo DNA-protein interactions in E. coli. Wang, M.X., Church, G.M. Nature (1992) [Pubmed]
  9. Similarities between prokaryotic and eukaryotic cyclic AMP-responsive promoter elements. Lin, Y.S., Green, M.R. Nature (1989) [Pubmed]
  10. Structure of catabolite gene activator protein at 2.9 A resolution suggests binding to left-handed B-DNA. McKay, D.B., Steitz, T.A. Nature (1981) [Pubmed]
  11. Mechanism of the down-regulation of cAMP receptor protein by glucose in Escherichia coli: role of autoregulation of the crp gene. Ishizuka, H., Hanamura, A., Inada, T., Aiba, H. EMBO J. (1994) [Pubmed]
  12. CooA, a CO-sensing transcription factor from Rhodospirillum rubrum, is a CO-binding heme protein. Shelver, D., Kerby, R.L., He, Y., Roberts, G.P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  13. Regulation of bacterial glycogen synthesis. Stimulation of glycogen synthesis by endogenous and exogenous cyclic adenosine 3':5'-monophosphate in Escherichia coli and the requirement for a functional CRP gene. Leckie, M.P., Ng, R.H., Porter, S.E., Compton, D.R., Dietzler, D.N. J. Biol. Chem. (1983) [Pubmed]
  14. Crystal structure of a cyclic AMP-independent mutant of catabolite gene activator protein. Weber, I.T., Gilliland, G.L., Harman, J.G., Peterkofsky, A. J. Biol. Chem. (1987) [Pubmed]
  15. Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli. Ebright, R.H., Cossart, P., Gicquel-Sanzey, B., Beckwith, J. Nature (1984) [Pubmed]
  16. Genetic strategy for analyzing specificity of dimer formation: Escherichia coli cyclic AMP receptor protein mutant altered in its dimerization specificity. Joung, J.K., Chung, E.H., King, G., Yu, C., Hirsh, A.S., Hochschild, A. Genes Dev. (1995) [Pubmed]
  17. Mutations that alter the allosteric nature of cAMP receptor protein of Escherichia coli. Aiba, H., Nakamura, T., Mitani, H., Mori, H. EMBO J. (1985) [Pubmed]
  18. Comparison of the binding sites for the Escherichia coli cAMP receptor protein at the lactose and galactose promoters. Kolb, A., Busby, S., Herbert, M., Kotlarz, D., Buc, H. EMBO J. (1983) [Pubmed]
  19. The cAMP-binding domains of the regulatory subunit of cAMP-dependent protein kinase and the catabolite gene activator protein are homologous. Weber, I.T., Takio, K., Titani, K., Steitz, T.A. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  20. Characterization of nine monoclonal antibodies against the Escherichia coli cyclic AMP receptor protein. Li, X.M., Krakow, J.S. J. Biol. Chem. (1985) [Pubmed]
  21. Regulation of intrinsic terminator by translation in Escherichia coli: transcription termination at a distance downstream. Abe, H., Abo, T., Aiba, H. Genes Cells (1999) [Pubmed]
  22. Extracellular accumulation of L-glutamate in adenylyl cyclase deficient or cyclic AMP receptor protein deficient mutants of Escherichia coli. Leung, K.L., Yamazaki, H. Can. J. Microbiol. (1980) [Pubmed]
  23. The change of DNA structure by specific binding of the cAMP receptor protein from rotation diffusion and dichroism measurements. Porschke, D., Hillen, W., Takahashi, M. EMBO J. (1984) [Pubmed]
  24. Transcription activation at Class II CRP-dependent promoters: identification of determinants in the C-terminal domain of the RNA polymerase alpha subunit. Savery, N.J., Lloyd, G.S., Kainz, M., Gaal, T., Ross, W., Ebright, R.H., Gourse, R.L., Busby, S.J. EMBO J. (1998) [Pubmed]
  25. A common role of CRP in transcription activation: CRP acts transiently to stimulate events leading to open complex formation at a diverse set of promoters. Tagami, H., Aiba, H. EMBO J. (1998) [Pubmed]
  26. Structural and functional relationships between Pasteurella multocida and enterobacterial adenylate cyclases. Mock, M., Crasnier, M., Duflot, E., Dumay, V., Danchin, A. J. Bacteriol. (1991) [Pubmed]
  27. Identification of a contact between arginine-180 of the catabolite gene activator protein (CAP) and base pair 5 of the DNA site in the CAP-DNA complex. Zhang, X.P., Ebright, R.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  28. cAMP receptor protein-cAMP plays a crucial role in glucose-lactose diauxie by activating the major glucose transporter gene in Escherichia coli. Kimata, K., Takahashi, H., Inada, T., Postma, P., Aiba, H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  29. Evidence for two promoters upstream of the pts operon: regulation by the cAMP receptor protein regulatory complex. Fox, D.K., Presper, K.A., Adhya, S., Roseman, S., Garges, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  30. Studies of the distribution of Escherichia coli cAMP-receptor protein and RNA polymerase along the E. coli chromosome. Grainger, D.C., Hurd, D., Harrison, M., Holdstock, J., Busby, S.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  31. Kinetic studies of cAMP-induced allosteric changes in cyclic AMP receptor protein from Escherichia coli. Małecki, J., Polit, A., Wasylewski, Z. J. Biol. Chem. (2000) [Pubmed]
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