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Gene Review

speB  -  agmatinase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2932, JW2904
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Disease relevance of speB

  • The speB gene of Escherichia coli encodes agmatine ureohydrolase (AUH), a putrescine biosynthetic enzyme [1].
  • In the extreme thermophile Thermus thermophilus, a disruption mutant of a gene homologous to speB (coding for agmatinase = agmatine ureohydrolase) accumulated N1-aminopropylagmatine (N8-amidino-1,8-diamino-4-azaoctane, N8-amidinospermidine), a new compound, whereas all other polyamines produced by the wild-type strain were absent from the cells [2].
  • Human mitochondrial agmatinase shows a considerable level of sequence similarity to bacterial agmatinases, including a putative agmatinase from Deinococcus radiodurans [3].

High impact information on speB


Chemical compound and disease context of speB


Biological context of speB


Associations of speB with chemical compounds

  • Consequently, agmatine affects selection between the monocistronic and the polycistronic modes of speB transcription [1].
  • In contrast, cyclic AMP (cAMP) repressed AUH activity of chromosomally encoded AUH but had no effect on plasmid-borne speB nor phi(speB-phoA) [1].

Analytical, diagnostic and therapeutic context of speB


  1. Influence of cyclic AMP, agmatine, and a novel protein encoded by a flanking gene on speB (agmatine ureohydrolase) in Escherichia coli. Szumanski, M.B., Boyle, S.M. J. Bacteriol. (1992) [Pubmed]
  2. N1-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus. Ohnuma, M., Terui, Y., Tamakoshi, M., Mitome, H., Niitsu, M., Samejima, K., Kawashima, E., Oshima, T. J. Biol. Chem. (2005) [Pubmed]
  3. Crystallization and preliminary X-ray crystallographic analysis of a putative agmatinase from Deinococcus radiodurans. Lee, J.A., Ahn, H.J., Ha, J.Y., Shim, S.M., Kim, K.H., Kim, H.K., Suh, S.W. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  4. Manganese is essential for catalytic activity of Escherichia coli agmatinase. Carvajal, N., López, V., Salas, M., Uribe, E., Herrera, P., Cerpa, J. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  5. Cloning and characterization of human agmatinase. Iyer, R.K., Kim, H.K., Tsoa, R.W., Grody, W.W., Cederbaum, S.D. Mol. Genet. Metab. (2002) [Pubmed]
  6. Nucleotide sequence and analysis of the speA gene encoding biosynthetic arginine decarboxylase in Escherichia coli. Moore, R.C., Boyle, S.M. J. Bacteriol. (1990) [Pubmed]
  7. Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling. Salas, M., Rodríguez, R., López, N., Uribe, E., López, V., Carvajal, N. Eur. J. Biochem. (2002) [Pubmed]
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