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Gene Review

nanA  -  N-acetylneuraminate lyase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3214, JW3194, npl
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Disease relevance of nanA

  • Cloning, sequence, and transcriptional regulation of the operon encoding a putative N-acetylmannosamine-6-phosphate epimerase (nanE) and sialic acid lyase (nanA) in Clostridium perfringens [1].
  • The regulation of the neuraminidase gene nanA was examined in Pseudomonas and as cloned and expressed in Escherichia coli [2].
  • Under the hyperosmolar conditions postulated to exist in the CF lung, nanA is likely to be expressed to facilitate the initial adherence of Pseudomonas to the respiratory tract [2].

High impact information on nanA


Biological context of nanA


Associations of nanA with chemical compounds


Other interactions of nanA

  • Among the sugars tested that were predicted to be products of the nan-encoded system, only the exogenous addition of sialic acid resulted in the dramatic induction of a chromosomal nanA-lacZ fusion or displaced NanR from its operator in vitro [13].

Analytical, diagnostic and therapeutic context of nanA


  1. Cloning, sequence, and transcriptional regulation of the operon encoding a putative N-acetylmannosamine-6-phosphate epimerase (nanE) and sialic acid lyase (nanA) in Clostridium perfringens. Walters, D.M., Stirewalt, V.L., Melville, S.B. J. Bacteriol. (1999) [Pubmed]
  2. Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression. Cacalano, G., Kays, M., Saiman, L., Prince, A. J. Clin. Invest. (1992) [Pubmed]
  3. A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein. Sadler, I., Chiang, A., Kurihara, T., Rothblatt, J., Way, J., Silver, P. J. Cell Biol. (1989) [Pubmed]
  4. Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase. Ohta, Y., Watanabe, K., Kimura, A. Nucleic Acids Res. (1985) [Pubmed]
  5. Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase. Lawrence, M.C., Barbosa, J.A., Smith, B.J., Hall, N.E., Pilling, P.A., Ooi, H.C., Marcuccio, S.M. J. Mol. Biol. (1997) [Pubmed]
  6. Mucin degradation in the human colon: production of sialidase, sialate O-acetylesterase, N-acetylneuraminate lyase, arylesterase, and glycosulfatase activities by strains of fecal bacteria. Corfield, A.P., Wagner, S.A., Clamp, J.R., Kriaris, M.S., Hoskins, L.C. Infect. Immun. (1992) [Pubmed]
  7. Derived structure of the putative sialic acid transporter from Escherichia coli predicts a novel sugar permease domain. Martinez, J., Steenbergen, S., Vimr, E. J. Bacteriol. (1995) [Pubmed]
  8. Serratia liquefaciens as a new host superior for overproduction and purification using the N-acetylneuraminate lyase gene of Escherichia coli. Yamamoto, K., Kawakami, B., Kawamura, Y., Kawai, K. Anal. Biochem. (1997) [Pubmed]
  9. Genetic and molecular analyses of Escherichia coli N-acetylneuraminate lyase gene. Kawakami, B., Kudo, T., Narahashi, Y., Horikoshi, K. J. Bacteriol. (1986) [Pubmed]
  10. Characterization and mutagenesis of the recombinant N-acetylneuraminate lyase from Clostridium perfringens: insights into the reaction mechanism. Krüger, D., Schauer, R., Traving, C. Eur. J. Biochem. (2001) [Pubmed]
  11. Redirection of sialic acid metabolism in genetically engineered Escherichia coli. Ringenberg, M., Lichtensteiger, C., Vimr, E. Glycobiology (2001) [Pubmed]
  12. The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli. Izard, T., Lawrence, M.C., Malby, R.L., Lilley, G.G., Colman, P.M. Structure (1994) [Pubmed]
  13. Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. Kalivoda, K.A., Steenbergen, S.M., Vimr, E.R., Plumbridge, J. J. Bacteriol. (2003) [Pubmed]
  14. Purification, crystallization and characterization of N-acetylneuraminate lyase from Escherichia coli. Aisaka, K., Igarashi, A., Yamaguchi, K., Uwajima, T. Biochem. J. (1991) [Pubmed]
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