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Gene Review

ENTPD4  -  ectonucleoside triphosphate...

Homo sapiens

Synonyms: Ectonucleoside triphosphate diphosphohydrolase 4, KIAA0392, LALP70, LAP70, LYSAL1, ...
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High impact information on ENTPD4


Biological context of ENTPD4

  • Using antibodies against autophagic vacuole membrane proteins we identified a human cDNA with an open reading frame of 1848 bp, encoding a protein of 70 kDa, which we named lysosomal apyrase-like protein of 70 kDa (LALP70) [3].

Anatomical context of ENTPD4


Associations of ENTPD4 with chemical compounds

  • 5. Detergent treatment with 0.1% sodium deoxycholate allows the partial solubilization of the glucosyltransferase and UDPase [6].

Other interactions of ENTPD4


Analytical, diagnostic and therapeutic context of ENTPD4


  1. First apyrase splice variants have different enzymatic properties. Biederbick, A., Kosan, C., Kunz, J., Elsässer, H.P. J. Biol. Chem. (2000) [Pubmed]
  2. Golgi localization and functional expression of human uridine diphosphatase. Wang, T.F., Guidotti, G. J. Biol. Chem. (1998) [Pubmed]
  3. A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles. Biederbick, A., Rose, S., Elsässer, H.P. J. Cell. Sci. (1999) [Pubmed]
  4. The catalytic site of the pectin biosynthetic enzyme alpha-1,4-galacturonosyltransferase is located in the lumen of the Golgi. Sterling, J.D., Quigley, H.F., Orellana, A., Mohnen, D. Plant Physiol. (2001) [Pubmed]
  5. Relationships between membranous organelles in amoebae studied by electron microscopic cytochemical staining. Flickinger, C.J. Cell Tissue Res. (1977) [Pubmed]
  6. Uridine diphosphate glucose-sterol glucosyltransferase and nucleoside diphosphatase activities in etiolated pea seedlings. Staver, M.J., Glick, K., Baisted, D.J. Biochem. J. (1978) [Pubmed]
  7. The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70. Biederbick, A., Rösser, R., Storre, J., Elsässer, H.P. BMC Biochem. (2004) [Pubmed]
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