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Gene Review

Hist2h4  -  histone cluster 2, H4

Mus musculus

Synonyms: H4, X04652
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Disease relevance of Hist2h4

  • The processed RNA is regulated in parallel with endogenous H4 mRNAs in 21-Tb cells, a temperature-sensitive mouse mastocytoma cell cycle mutant that is specifically blocked in G1 phase at the non-permissive temperature [1].
  • Moreover, fusion of the simian virus 40 (SV40) early promoter to a 463-bp fragment containing the 3'-terminal half of the mouse H4 gene, including 230 bp of spacer sequences, led to the regulated expression of SV40/H4 fusion RNA [2].
  • Histone H4 gene expression, which is tightly coupled to DNA synthesis and thus an index of cell proliferation, showed only a minimal increase in cystic kidneys at 1, 2, and 3 weeks of age [3].

High impact information on Hist2h4

  • A signal regulating mouse histone H4 mRNA levels in a mammalian cell cycle mutant and sequences controlling RNA 3' processing are both contained within the same 80-bp fragment [1].
  • Fragments from the 3' end of a mouse histone H4 gene, when introduced into transcription units controlled by the SV40 early promoter, yield correctly processed RNA with histone-specific 3' ends, both in monkey and mouse cell lines [1].
  • These results show that sequences in the 3'-terminal part of the H4 gene can regulate gene expression in the cell cycle, presumably at the post-transcriptional level, as long as they are not positioned much more distant from the terminus than normal [2].
  • One of these cell lines (line 6-8) contains more than 60 human H4 gene copies per haploid genome and does not express the endogenous mouse histone H4 mRNA [4].
  • The mouse histone H4 gene, when stably transformed into L cells on the PSV2gpt shuttle vector, is cell cycle regulated in parallel with the endogenous H4 genes [5].

Biological context of Hist2h4

  • However, B-myb and histone H4 expression are uncoupled during spermatogenesis in the adult mouse [6].
  • Nucleotide sequence of two mouse histone H4 genes [7].
  • In situ hybridization reveals a tight linkage between B-myb expression and proliferative activity (as assessed by the expression of the S-phase specific histone H4 gene) in most tissues and throughout embryonic development [6].
  • Addition of nonhydrolyzable nucleotide analogs of ATP to the in vitro system used for measurement of RNA transport did not result in release of nonhistone mRNA (actin), but enhanced the efflux of H4 mRNA to approximately the same extent as ATP [8].

Anatomical context of Hist2h4

  • Histone H4 is expressed at high levels in the early spermatogenic progenitor cells but not in successive stages of sperm cell development [6].

Associations of Hist2h4 with chemical compounds

  • Newly synthesized histones were pulse-labeled in vivo by L-[3H]lysine, and the time course of the uptake of label into monomethyl, dimethyl and trimethyllysine from gel-electrophoretically isolated histones F2a1 (H4) and F3 (H3) was followed [9].


  1. A signal regulating mouse histone H4 mRNA levels in a mammalian cell cycle mutant and sequences controlling RNA 3' processing are both contained within the same 80-bp fragment. Stauber, C., Lüscher, B., Eckner, R., Lötscher, E., Schümperli, D. EMBO J. (1986) [Pubmed]
  2. Faithful cell-cycle regulation of a recombinant mouse histone H4 gene is controlled by sequences in the 3'-terminal part of the gene. Lüscher, B., Stauber, C., Schindler, R., Schümperli, D. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Autosomal recessive polycystic kidney disease in a murine model. A gross and microscopic description. Gattone, V.H., Calvet, J.P., Cowley, B.D., Evan, A.P., Shaver, T.S., Helmstadter, K., Grantham, J.J. Lab. Invest. (1988) [Pubmed]
  4. Regulated expression of mammalian histone H4 genes in vivo requires a trans-acting transcription factor. Capasso, O., Heintz, N. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  5. Cell cycle regulation of a mouse histone H4 gene requires the H4 promoter. Seiler-Tuyns, A., Paterson, B.M. Mol. Cell. Biol. (1987) [Pubmed]
  6. Expression of B-Myb during mouse embryogenesis. Sitzmann, J., Noben-Trauth, K., Kamano, H., Klempnauer, K.H. Oncogene (1996) [Pubmed]
  7. Nucleotide sequence of two mouse histone H4 genes. Meier, V.S., Böhni, R., Schümperli, D. Nucleic Acids Res. (1989) [Pubmed]
  8. Energy requirement and kinetics of transport of poly(A)-free histone mRNA compared to poly(A)-rich mRNA from isolated L-cell nuclei. Schröder, H.C., Friese, U., Bachmann, M., Zaubitzer, T., Müller, W.E. Eur. J. Biochem. (1989) [Pubmed]
  9. Kinetics of histone methylation in vivo and its relation to the cell cycle in Ehrlich ascites tumor cells. Thomas, G., Lange, H.W., Hempel, K. Eur. J. Biochem. (1975) [Pubmed]
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