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Gene Review

GOLGA5  -  golgin A5

Homo sapiens

Synonyms: Cell proliferation-inducing gene 31 protein, GOLIM5, Golgin subfamily A member 5, Golgin-84, PIG31, ...
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Disease relevance of GOLGA5


High impact information on GOLGA5

  • Golgin-84 binds to active rab1 but not cis-Golgi matrix proteins [3].
  • In agreement with other rearranged TKs, it is concluded that the transforming action of the new fusion protein rfg5/ret in thyroid tumors may be due to an activation of the ret TK by constitutive expression and dimerization potential of the 5'-fused rfg5 protein [1].
  • Ret-II is a transfection artifact in NIH3T3 cells and has not yet been detected in any human tumor [1].
  • Overlapping sequences found in the expressed sequence tag databases enabled us to sequence the COOH terminus of the ret-fused gene 5 (RFG5) [1].
  • This model is brought into question by new evidence that two golgins, GM130 and golgin-84, contribute to but are not essential for protein transport and Golgi structure [4].

Biological context of GOLGA5


Anatomical context of GOLGA5


Other interactions of GOLGA5

  • Structurally, golgin-67 resembles, golgin-84, an integral membrane Golgi protein with an N-terminal coiled-coil domain and a single C-terminal transmembrane domain [8].
  • We also examined two other Golgi-resident proteins, golgin-84 and syntaxin-5, with a similar membrane topology as giantin [9].

Analytical, diagnostic and therapeutic context of GOLGA5


  1. Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5. Klugbauer, S., Demidchik, E.P., Lengfelder, E., Rabes, H.M. Cancer Res. (1998) [Pubmed]
  2. Molecular cloning and characterization of human ret-II oncogene. Ishizaka, Y., Tahira, T., Ochiai, M., Ikeda, I., Sugimura, T., Nagao, M. Oncogene Res. (1988) [Pubmed]
  3. The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. Diao, A., Rahman, D., Pappin, D.J., Lucocq, J., Lowe, M. J. Cell Biol. (2003) [Pubmed]
  4. Membrane traffic: a glitch in the Golgi matrix. Short, B., Barr, F.A. Curr. Biol. (2003) [Pubmed]
  5. Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing. Ishizaka, Y., Ochiai, M., Tahira, T., Sugimura, T., Nagao, M. Oncogene (1989) [Pubmed]
  6. cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line. Ishizaka, Y., Ushijima, T., Sugimura, T., Nagao, M. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  7. Loss of amplified genes by poly(ADP-ribose) polymerase inhibitors. Nagao, M., Nakayasu, M., Aonuma, S., Shima, H., Sugimura, T. Environ. Health Perspect. (1991) [Pubmed]
  8. Identification and characterization of a novel Golgi protein, golgin-67. Jakymiw, A., Raharjo, E., Rattner, J.B., Eystathioy, T., Chan, E.K., Fujita, D.J. J. Biol. Chem. (2000) [Pubmed]
  9. An essential cytoplasmic domain for the Golgi localization of coiled-coil proteins with a COOH-terminal membrane anchor. Misumi, Y., Sohda, M., Tashiro, A., Sato, H., Ikehara, Y. J. Biol. Chem. (2001) [Pubmed]
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