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High impact information on Arnica

  • Sesquiterpene lactones seem to be the most important NF-kappaB inhibiting compounds in the Arnica extract [1].
  • Epidemiological data are available for 2 species only, arnica and German chamomile, the rest of the evidence being anecdotal [2].
  • NMR spectroscopy: a useful tool for characterisation of plant extracts, the case of supercritical CO2 arnica extract [3].
  • Sesquiterpenoids, 7-hydroxy-3,4-dihydrocadalin and 7-hydroxycadalin, and flavonoids, quercetin, kaempferol and their glycosides, isolated from Heterotheca inuloides (Asteraceae), a Mexican medicinal plant known as "arnica", were evaluated as antioxidants [4].
  • SETTING: Department of Gynecology, Shaare Zedek Medical Center, Jerusalem. INTERVENTIONS: Forty parturients were randomized to one of three groups: Arnica montana C6 and Bellis perennis C6 (n=14), Arnica montana C30 and Bellis perennis C30 (n=14), or double placebo (n=12) [5].

Anatomical context of Arnica

  • A double blind trial, was designed, in which 118 patients undergoing the removal of impacted wisdom teeth were randomly divided into the following groups; 41 patients received Metronidazole, 39 patients received Arnica Montana, 38 patients received the placebo [6].

Associations of Arnica with chemical compounds

  • Arnica and propolis extracts (20 microl) were added to these tubes to evaluate the % of inhibition of cell adherence and water-insoluble glucan formation [7].
  • Metronidazole was more effective in pain control than Arnica (p less than 0.001) and placebo (p less than 0.01) [6].
  • Separate groups of sonicated mice were either orally administered with Arnica 30 (alcohol 30 in control) or injected intramuscularly with Actinomycin-D (AMD) [8].
  • Thus there is synergy between the active agents arnica and hydroxyethyl salicylate in the combination preparation [9].
  • In the chronic model, Nystatin-induced oedema, the group treated 3 days previously with Arnica montana 6cH had reduced inflammation 6 h after the inflammatory agent was applied (P < 0.05) [10].

Gene context of Arnica

  • Phytopharmaceuticals prepared from flowerheads of Arnica montana of Spanish origin and of the new type "Arbo", which can be easily and economically cultivated, were studied for their capability to impair activation of the transcription factors NF-kappa B and NF-AT [11].
  • 64 adults undergoing elective surgery for carpal tunnel syndrome were randomized to take three tablets daily of homeopathic arnica 30C or 6C or placebo for seven days before surgery and fourteen days after surgery [12].


  1. New sesquiterpene lactones from Arnica tincture prepared from fresh flowerheads of Arnica montana. Kos, O., Lindenmeyer, M.T., Tubaro, A., Sosa, S., Merfort, I. Planta Med. (2005) [Pubmed]
  2. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Paulsen, E. Contact Derm. (2002) [Pubmed]
  3. NMR spectroscopy: a useful tool for characterisation of plant extracts, the case of supercritical CO2 arnica extract. Bilia, A.R., Bergonzi, M.C., Mazzi, G., Vincieri, F.F. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  4. Antioxidative constituents in Heterotheca inuloides. Haraguchi, H., Ishikawa, H., Sanchez, Y., Ogura, T., Kubo, Y., Kubo, I. Bioorg. Med. Chem. (1997) [Pubmed]
  5. The effect of the homeopathic remedies Arnica montana and Bellis perennis on mild postpartum bleeding--a randomized, double-blind, placebo-controlled study--preliminary results. Oberbaum, M., Galoyan, N., Lerner-Geva, L., Singer, S.R., Grisaru, S., Shashar, D., Samueloff, A. Complementary therapies in medicine. (2005) [Pubmed]
  6. Metronidazole (Flagyl) and Arnica Montana in the prevention of post-surgical complications, a comparative placebo controlled clinical trial. Kaziro, G.S. The British journal of oral & maxillofacial surgery. (1984) [Pubmed]
  7. In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens. Koo, H., Gomes, B.P., Rosalen, P.L., Ambrosano, G.M., Park, Y.K., Cury, J.A. Arch. Oral Biol. (2000) [Pubmed]
  8. Cytogenetical effects of sonication in mice and their modulations by actinomycin D and a homeopathic drug, Arnica 30. Chakrabarti, J., Biswas, S.J., Khuda-Bukhsh, A.R. Indian J. Exp. Biol. (2001) [Pubmed]
  9. Synergetic analgesic effect of the combination of arnica and hydroxyethyl salicylate in ethanolic solution following cutaneous application by transcutaneous electrostimulation. Kucera, M., Horácek, O., Kálal, J., Kolár, P., Korbelar, P., Polesná, Z. Arzneimittel-Forschung. (2003) [Pubmed]
  10. Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals. Macêdo, S.B., Ferreira, L.R., Perazzo, F.F., Carvalho, J.C. Homeopathy : the journal of the Faculty of Homeopathy. (2004) [Pubmed]
  11. Studies on the anti-inflammatory activity of phytopharmaceuticals prepared from Arnica flowers. Klaas, C.A., Wagner, G., Laufer, S., Sosa, S., Della Loggia, R., Bomme, U., Pahl, H.L., Merfort, I. Planta Med. (2002) [Pubmed]
  12. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. Stevinson, C., Devaraj, V.S., Fountain-Barber, A., Hawkins, S., Ernst, E. Journal of the Royal Society of Medicine. (2003) [Pubmed]
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