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MeSH Review

Pichinde Virus

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Disease relevance of Pichinde Virus

  • These are completely conserved among the predicted polyprotein sequences of all the CCHF virus strains and closely resemble the tetrapeptides that represent the major cleavage recognition sites present in the glycoprotein precursors of arenaviruses, such as Lassa fever virus (RRLL) and Pichinde virus (RKLL) [1].
  • BBdp rats fail to generate virus-specific major histocompatibility complex-restricted cytotoxic T lymphocyte (CTL) responses when challenged with this dose or other doses of LCMV, Pichinde virus or vaccinia virus [2].
  • The most active inhibitors, named NSC20625, 3-7 and 2-71, demonstrated a broad range of action against arenaviruses, including several attenuated and pathogenic strains of JUNV as well as the antigenically related Tacaribe virus (TACV) and Pichinde virus (PICV) [3].

High impact information on Pichinde Virus


Chemical compound and disease context of Pichinde Virus


Gene context of Pichinde Virus

  • For Pichinde virus, it has been shown that the 3' proximal gene product (the nucleoprotein, N) is translated from a subgenomic, viral-complementary mRNA (Auperin et al., 1984a) [12].
  • In view of this, and if, like Pichinde virus, LCM has an ambisense S RNA coding strategy, then it is probable that the intergenic hairpins function as transcription terminators for the N and GPC mRNA species of both viruses [12].
  • The nucleoprotein of Pichinde virus expressed by a vaccinia-Pichinde virus recombinant partially protects hamsters from lethal virus challenge [13].


  1. Characterization of the glycoproteins of Crimean-Congo hemorrhagic fever virus. Sanchez, A.J., Vincent, M.J., Nichol, S.T. J. Virol. (2002) [Pubmed]
  2. Cytotoxic T lymphocytes do not control lymphocytic choriomeningitis virus infection of BB diabetes-prone rats. Oldstone, M.B., Tishon, A., Schwimmbeck, P.L., Shyp, S., Lewicki, H., Dyrberg, T. J. Gen. Virol. (1990) [Pubmed]
  3. Antiviral and virucidal activities against arenaviruses of zinc-finger active compounds. García, C.C., Candurra, N.A., Damonte, E.B. Antivir. Chem. Chemother. (2000) [Pubmed]
  4. Alterations in NF-kappaB and RBP-Jkappa by arenavirus infection of macrophages in vitro and in vivo. Fennewald, S.M., Aronson, J.F., Zhang, L., Herzog, N.K. J. Virol. (2002) [Pubmed]
  5. Characterization of Pichinde virus infection of cells of the monocytic lineage. Polyak, S.J., Rawls, W.E., Harnish, D.G. J. Virol. (1991) [Pubmed]
  6. Distinctive RNA transcriptase, polyadenylic acid polymerase, and polyuridylic acid polymerase activities associated with Pichinde virus. Leung, W.C., Leung, M.F., Rawls, W.E. J. Virol. (1979) [Pubmed]
  7. Strandedness of Pichinde virus RNA. Leung, W.C., Ghosh, H.P., Rawls, W.E. J. Virol. (1977) [Pubmed]
  8. Inhibition of Pichinde virus replication by actinomycin D. Rawls, W.E., Banerjee, S.N., McMillan, C.A., Buchmeier, M.J. J. Gen. Virol. (1976) [Pubmed]
  9. Arenavirus inactivation on contact with N-substituted isatin beta-thiosemicarbazones and certain cations. Logan, J.C., Fox, M.P., Morgan, J.H., Makohon, A.M., Pfau, C.J. J. Gen. Virol. (1975) [Pubmed]
  10. Pathogenesis of Pichinde virus infection in strain 13 guinea pigs: an immunocytochemical, virologic, and clinical chemistry study. Connolly, B.M., Jenson, A.B., Peters, C.J., Geyer, S.J., Barth, J.F., McPherson, R.A. Am. J. Trop. Med. Hyg. (1993) [Pubmed]
  11. Antiviral efficacy of pyrazofurin against selected RNA viruses. Canonico, P.G., Jahrling, P.B., Pannier, W.L. Antiviral Res. (1982) [Pubmed]
  12. Conserved sequences and coding of two strains of lymphocytic choriomeningitis virus (WE and ARM) and Pichinde arenavirus. Romanowski, V., Bishop, D.H. Virus Res. (1985) [Pubmed]
  13. The nucleoprotein of Pichinde virus expressed by a vaccinia-Pichinde virus recombinant partially protects hamsters from lethal virus challenge. Ozols, D.Y., Rawls, W.E., Rosenthal, K.L., Harnish, D.G. Arch. Virol. (1994) [Pubmed]
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