Disease relevance of Chicken Anemia Virus

• Apoptin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells [1].
• The purpose of this series of experiments was to determine the effect of various types of immunosuppressive treatments (cyclophosphamide, infectious bursal disease virus [IBDV], chicken anemia virus [CAV], and combination infection with IBDV and CAV) on susceptibility of chickens to challenge with avian polyomavirus [2].

High impact information on Chicken Anemia Virus

• The chicken anemia virus protein Apoptin induces apoptosis in the absence of p53 by a mechanism that remains to be elucidated [3].
• Chicken anemia virus VP2 is a novel dual specificity protein phosphatase [4].
• Mutation of chicken anemia virus VP2 differentially affects serine/threonine and tyrosine protein phosphatase activities [5].
• We also use it to examine, for the first time, IMP binding to the cancer cell-specific proapoptotic factor viral protein 3 (VP3) from the chicken anemia virus (CAV) [6].
• The immunopathologic effects induced by two attenuated chicken anemia virus (CAV) isolates, known as cloned isolate 34 (CI 34) and cloned revertant isolate 18 (CRI 18), that were derived from highly passaged pools of Cux-1 CAV isolate, were compared with those induced by a pathogenic, molecularly cloned, low-passage Cux-1 isolate (CI Cux) [7].

Chemical compound and disease context of Chicken Anemia Virus

• Particles of chicken anemia agent (CAA) negatively stained with uranyl acetate were found to be 26.5 nm in diameter [8].
• MSB-1 cells infected with the Cux-1 strain of chicken anemia agent, but not to uninfected MSB-1 cells were found to react with fluorescein isothiocyanate conjugates [9].
• In situ hybridization for the detection of chicken anemia virus in formalin-fixed, paraffin-embedded sections [10].
• The recognition of antigen in tissues by monoclonal antibodies is also discussed using as examples; the vitamin biotin, the chicken anemia virus, the growth promoter clenbuterol and the bovine lymphokine, gamma interferon [11].

Anatomical context of Chicken Anemia Virus

• Apoptin, a small protein derived from chicken anemia virus (CAV), induces apoptosis in human tumor cell lines regardless of whether these express p53 or not [12].

Gene context of Chicken Anemia Virus

• Mice were immunized with partially purified preparations of the Cux-1 isolate of chicken anemia agent (CAA), and their splenocytes were fused with NSO myeloma cells [13].
• Inactivated E. faecalis, chicken anemia virus and reovirus did not cause amyloid arthropathy after intra-articular inoculation [14].

References