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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Infectious Bursal Disease Virus

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Disease relevance of Infectious Bursal Disease Virus


High impact information on Infectious Bursal Disease Virus

  • We have found that expression of a mutant version of the VP3 structural polypeptide known as VP3/M3, partially lacking the domain responsible for the interaction with the virus-encoded RNA polymerase, efficiently interferes with the IBDV replication cycle [6].
  • Incorporation of VP1 into VLPs requires neither the presence of IBDV RNAs nor that of the nonstructural polypeptide VP5 [7].
  • Recently, the establishment of an infectious cRNA system for IBDV has been described (E. Mundt and V. N. Vakharia, Proc. Natl. Acad. Sci. USA 93:11131-11136, 1996) [8].
  • The proteolytic cascade involved in processing the polyprotein, and in the final maturation of pVP2 (the precursor of VP2), has recently been shown to generate VP2 and four structural peptides in infectious bursal disease virus and blotched snakehead virus [9].
  • Coadministration of a plasmid encoding the VP2 gene of IBDV (pCI-VP2) and a plasmid encoding chicken IL-2 gene (pCI-chIL-2) enhances bursal protection against both the homologous IBDV strain ZJ2000 and the heterologous strain BC6/85 compared to administration of pCI-VP2 alone [10].

Chemical compound and disease context of Infectious Bursal Disease Virus

  • Our results suggest that the replacement of serine by lysine in AXAAS motifs in serotype II IBDV influences polyprotein (PP) processing by VP4 and also indicate the presence of an alternative cleavage site [11].
  • An anchor probe labeled with LightCycler Red 640 and mutation probe labeled with fluorescein were designed using the Del-E IBDV sequence [12].
  • This paper describes the results of immuno-histochemical staining for chicken mannan-binding lectin (MBL) in formalin-fixed tissue sections from non-infected chickens, and from chickens infected with infectious laryngotracheitis virus (ILTV) or infectious bursal disease virus (IBDV) [13].
  • Chickens vaccinated with IP strain and supplemented with 2% L-arginine showed 100% protection after challenge with virulent IBDV compared to 80% protection induced by IP strain alone [14].
  • Fluorescence spectroscopy monitoring of the conformational restraint of formaldehyde- and glutaraldehyde-treated infectious bursal disease virus proteins [15].

Biological context of Infectious Bursal Disease Virus


Anatomical context of Infectious Bursal Disease Virus


Gene context of Infectious Bursal Disease Virus

  • The sequences of segment A (encoding the VP2-VP4-VP3 polyprotein and VP5) and segment B (encoding VP1) of a recent, 'very virulent' (VV) European isolate (UK661) of infectious bursal disease virus (IBDV), a birnavirus, have been determined [22].
  • The optimum quantity of MAP1 and MAP2 required to coat the wells of the ELISA plate was 5 ng/ml, whereas the amount of purified IBDV whole viral antigen was 500 ng/ml, indicating the high efficiency of MAPs [23].
  • Since interferon (IFN) production has been demonstrated after IBDV infection, IFN was considered to be one of several factors [24].
  • The immunoregulatory activity of a nonmammalian interleukin 2 (IL-2), chicken IL-2 (chIL-2), was investigated using a DNA vaccine against infectious bursal disease virus (IBDV) as a model [10].
  • These results on the IBDV VP4 confirm and extend our previous characterization of the IPNV VP4, delineating the birnavirus protease as a new type of viral serine protease [25].

Analytical, diagnostic and therapeutic context of Infectious Bursal Disease Virus


  1. The last C-terminal residue of VP3, glutamic acid 257, controls capsid assembly of infectious bursal disease virus. Chevalier, C., Lepault, J., Da Costa, B., Delmas, B. J. Virol. (2004) [Pubmed]
  2. Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus. Petit, S., Lejal, N., Huet, J.C., Delmas, B. J. Virol. (2000) [Pubmed]
  3. Protection of chickens against very virulent infectious bursal disease virus (IBDV) and Marek's disease virus (MDV) with a recombinant MDV expressing IBDV VP2. Tsukamoto, K., Kojima, C., Komori, Y., Tanimura, N., Mase, M., Yamaguchi, S. Virology (1999) [Pubmed]
  4. Chicken anemia virus and infectious bursal disease virus interfere with transcription of chicken IFN-alpha and IFN-gamma mRNA. Ragland, W.L., Novak, R., El-Attrache, J., Savić, V., Ester, K. J. Interferon Cytokine Res. (2002) [Pubmed]
  5. The in vivo and in vitro effects of chicken interferon alpha on infectious bursal disease virus and Newcastle disease virus infection. Mo, C.W., Cao, Y.C., Lim, B.L. Avian Dis. (2001) [Pubmed]
  6. Intracellular interference of infectious bursal disease virus. González, D., Rodríguez, J.F., Abaitua, F. J. Virol. (2005) [Pubmed]
  7. VP1, the putative RNA-dependent RNA polymerase of infectious bursal disease virus, forms complexes with the capsid protein VP3, leading to efficient encapsidation into virus-like particles. Lombardo, E., Maraver, A., Cast n, J.R., Rivera, J., Fernández-Arias, A., Serrano, A., Carrascosa, J.L., Rodriguez, J.F. J. Virol. (1999) [Pubmed]
  8. VP5 of infectious bursal disease virus is not essential for viral replication in cell culture. Mundt, E., Köllner, B., Kretzschmar, D. J. Virol. (1997) [Pubmed]
  9. Peptides resulting from the pVP2 C-terminal processing are present in infectious pancreatic necrosis virus particles. Galloux, M., Chevalier, C., Henry, C., Huet, J.C., Costa, B.D., Delmas, B. J. Gen. Virol. (2004) [Pubmed]
  10. Enhancement of the immunogenicity of DNA vaccine against infectious bursal disease virus by co-delivery with plasmid encoding chicken interleukin 2. Li, J., Liang, X., Huang, Y., Meng, S., Xie, R., Deng, R., Yu, L. Virology (2004) [Pubmed]
  11. Site-directed mutagenesis of Avibirnavirus VP4 gene. Rodríguez-Lecompte, J.C., Kibenge, F.S. Virology (2002) [Pubmed]
  12. Identification of infectious bursal disease virus quasispecies in commercial vaccines and field isolates of this double-stranded RNA virus. Jackwood, D.J., Sommer, S.E. Virology (2002) [Pubmed]
  13. Immunohistochemical investigation of the tissue distribution of mannan-binding lectin in non-infected and virus-infected chickens. Nielsen, O.L., Jørgensen, P.H., Hedemand, J., Jensenius, J.C., Koch, C., Laursen, S.B. Immunology (1998) [Pubmed]
  14. L-arginine stimulates immune response in chickens immunized with intermediate plus strain of infectious bursal disease vaccine. Tayade, C., Jaiswal, T.N., Mishra, S.C., Koti, M. Vaccine (2006) [Pubmed]
  15. Fluorescence spectroscopy monitoring of the conformational restraint of formaldehyde- and glutaraldehyde-treated infectious bursal disease virus proteins. Cepica, A., Beauregard, M., Qian, B. Vaccine (1998) [Pubmed]
  16. Genome cloning and analysis of the large RNA segment (segment A) of a naturally avirulent serotype 2 infectious bursal disease virus. Kibenge, F.S., McKenna, P.K., Dybing, J.K. Virology (1991) [Pubmed]
  17. Infectious bursal disease virus of chickens: pathogenesis and immunosuppression. Sharma, J.M., Kim, I.J., Rautenschlein, S., Yeh, H.Y. Dev. Comp. Immunol. (2000) [Pubmed]
  18. Response of mibolerone-treated chickens to infectious bursal disease virus. Lucio, B., Hitchner, S.B. Avian Dis. (1980) [Pubmed]
  19. Role of the bursa of Fabricius in the pathogenicity of inclusion body hepatitis and infectious bursal disease viruses. Fadly, A.M., Winterfield, R.W., Olander, H.J. Avian Dis. (1976) [Pubmed]
  20. VP5, the nonstructural polypeptide of infectious bursal disease virus, accumulates within the host plasma membrane and induces cell lysis. Lombardo, E., Maraver, A., Espinosa, I., Fernández-Arias, A., Rodriguez, J.F. Virology (2000) [Pubmed]
  21. Vaccination against infectious bronchitis and the immunosuppressive effects of infectious bursal disease. Winterfield, R.W., Hoerr, F.J., Fadly, A.M. Poult. Sci. (1978) [Pubmed]
  22. Coding sequences of both genome segments of a European 'very virulent' infectious bursal disease virus. Brown, M.D., Skinner, M.A. Virus Res. (1996) [Pubmed]
  23. Use of multiple antigenic peptides related to antigenic determinants of infectious bursal disease virus (IBDV) for detection of anti-IBDV-specific antibody in ELISA--quantitative comparison with native antigen for their use in serodiagnosis. Saravanan, P., Kumar, S., Kataria, J.M. J. Immunol. Methods (2004) [Pubmed]
  24. Apoptosis is induced by infectious bursal disease virus replication in productively infected cells as well as in antigen-negative cells in their vicinity. Jungmann, A., Nieper, H., Müller, H. J. Gen. Virol. (2001) [Pubmed]
  25. Role of Ser-652 and Lys-692 in the protease activity of infectious bursal disease virus VP4 and identification of its substrate cleavage sites. Lejal, N., Da Costa, B., Huet, J.C., Delmas, B. J. Gen. Virol. (2000) [Pubmed]
  26. A rapid quantitative method for detecting infectious bursal disease virus using polystyrene latex microspheres. Nakamura, T., Kato, A., Lin, Z., Hiraga, M., Nunoya, T., Otaki, Y., Ueda, S. J. Virol. Methods (1993) [Pubmed]
  27. Detection of infectious bursal disease virus in digested formalin-fixed paraffin-embedded tissue sections by polymerase chain reaction. Wu, C.C., Lin, T.L. J. Vet. Diagn. Invest. (1992) [Pubmed]
  28. Role of intrabursal T cells in infectious bursal disease virus (IBDV) infection: T cells promote viral clearance but delay follicular recovery. Rautenschlein, S., Yeh, H.Y., Njenga, M.K., Sharma, J.M. Arch. Virol. (2002) [Pubmed]
  29. Experimental inoculation of avian polyomavirus in chemically and virally immunosuppressed chickens. Fitzgerald, S.D., Kingwill, S.J., Briggs, S., Awolaja, O., Basile, A., Griffioen, L., Potter, E.A., Wu, C.C., Taylor, S.P., Reed, W.M. Avian Dis. (1999) [Pubmed]
  30. Immunohistochemical detection of infectious bursal disease virus in formalin-fixed, paraffin-embedded chicken tissues using monoclonal antibody. Cruz-Coy, J.S., Giambrone, J.J., Hoerr, F.J. Avian Dis. (1993) [Pubmed]
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