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MeSH Review:

Impulsive Behavior

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Disease relevance of Impulsive Behavior

Other major manifestations include microcephaly, intrauterine growth retardation, mental retardation, and a characteristic hyperactive, impulsive behavior [1].

Psychiatry related information on Impulsive Behavior

CONCLUSIONS: Low 5-HT synthesis capacity in corticostriatal pathways may contribute to the development of impulsive behaviors in persons with borderline personality disorder [2].

High impact information on Impulsive Behavior

No association of TPH genotype with impulsive behavior was detected [3].
Prostaglandin E receptor EP1 controls impulsive behavior under stress [4].
CONCLUSIONS: Dietary studies are indicated to determine if essential fatty acid supplementation can influence central nervous system serotonin and dopamine metabolism and modify impulsive behaviors related to these neurotransmitters [5].
BACKGROUND: Among an independent group of subjects selected for their history of violent, impulsive behaviors and nonviolent control subjects, we attempted to replicate the finding that plasma docosahexaenoic acid concentrations were negatively correlated with cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA) concentrations [6].
In the current study, the effects of intra-accumbal infusions of 6-hydroxydopamine (6-OHDA) on impulsive choice were evaluated, in combination with d-amphetamine and serotonergic drugs, in order to investigate the importance of 5-HT : DA interactions in the control of impulsive behavior [7].

Chemical compound and disease context of Impulsive Behavior

(2) CSF 5-HIAA concentrations were negatively correlated with impulsive behavior, and severe, unrestrained aggression, but not with overall rates of aggression [8].
Lithium treatment of impulsive behavior in children [9].
Haloperidol (4-16 mg/day) produced significant improvement over placebo in global functioning, depression, hostility, schizotypal symptoms, and impulsive behavior [10].
Effects of methamphetamine on the adjusting amount procedure, a model of impulsive behavior in rats [11].
Methylphenidate in hyperkinetic children: differences in dose effects on impulsive behavior [12].

Biological context of Impulsive Behavior

Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice [13].

Gene context of Impulsive Behavior

While several classes of substances of abuse may ameliorate various symptoms of ADHD, individuals with ADHD may also be vulnerable to substance use because of poor judgment or impulsive behavior in social settings [14].
Wolfram syndrome and suicide: Evidence for a role of WFS1 in suicidal and impulsive behavior [15].
Those rules, and their application to the role of the DRD2 gene in addictive, impulsive behaviors, are reviewed [16].
However, a replication study with a larger sample and an investigation of psychiatric patients with pathological levels of impulsivity are necessary to qualify these topographical ERP-parameters of cognitive response control as valid measures of the brain electrical basis of impulsive behavior [17].
Taken together, NO appears to play an important role in normal brain 5-HT function and may have significant implications for the treatment of psychiatric disorders characterized by aggressive and impulsive behaviors [18].

References

Delineation of the critical deletion region for congenital heart defects, on chromosome 8p23.1. Devriendt, K., Matthijs, G., Van Dael, R., Gewillig, M., Eyskens, B., Hjalgrim, H., Dolmer, B., McGaughran, J., Bröndum-Nielsen, K., Marynen, P., Fryns, J.P., Vermeesch, J.R. Am. J. Hum. Genet. (1999) [Pubmed]
Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. Leyton, M., Okazawa, H., Diksic, M., Paris, J., Rosa, P., Mzengeza, S., Young, S.N., Blier, P., Benkelfat, C. The American journal of psychiatry. (2001) [Pubmed]
Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Nielsen, D.A., Goldman, D., Virkkunen, M., Tokola, R., Rawlings, R., Linnoila, M. Arch. Gen. Psychiatry (1994) [Pubmed]
Prostaglandin E receptor EP1 controls impulsive behavior under stress. Matsuoka, Y., Furuyashiki, T., Yamada, K., Nagai, T., Bito, H., Tanaka, Y., Kitaoka, S., Ushikubi, F., Nabeshima, T., Narumiya, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. Hibbeln, J.R., Linnoila, M., Umhau, J.C., Rawlings, R., George, D.T., Salem, N. Biol. Psychiatry (1998) [Pubmed]
A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids. Hibbeln, J.R., Umhau, J.C., Linnoila, M., George, D.T., Ragan, P.W., Shoaf, S.E., Vaughan, M.R., Rawlings, R., Salem, N. Biol. Psychiatry (1998) [Pubmed]
Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders. Winstanley, C.A., Theobald, D.E., Dalley, J.W., Robbins, T.W. Neuropsychopharmacology (2005) [Pubmed]
CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors. Higley, J.D., Mehlman, P.T., Poland, R.E., Taub, D.M., Vickers, J., Suomi, S.J., Linnoila, M. Biol. Psychiatry (1996) [Pubmed]
Lithium treatment of impulsive behavior in children. Siassi, I. The Journal of clinical psychiatry. (1982) [Pubmed]
Amitriptyline versus haloperidol in borderlines: final outcomes and predictors of response. Soloff, P.H., George, A., Nathan, S., Schulz, P.M., Cornelius, J.R., Herring, J., Perel, J.M. Journal of clinical psychopharmacology. (1989) [Pubmed]
Effects of methamphetamine on the adjusting amount procedure, a model of impulsive behavior in rats. Richards, J.B., Sabol, K.E., de Wit, H. Psychopharmacology (Berl.) (1999) [Pubmed]
Methylphenidate in hyperkinetic children: differences in dose effects on impulsive behavior. Brown, R.T., Sleator, E.K. Pediatrics (1979) [Pubmed]
Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice. Brunner, D., Hen, R. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
Attention deficit/hyperactivity disorder and substance abuse. Diagnostic and therapeutic considerations. Sullivan, M.A., Rudnik-Levin, F. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
Wolfram syndrome and suicide: Evidence for a role of WFS1 in suicidal and impulsive behavior. Sequeira, A., Kim, C., Seguin, M., Lesage, A., Chawky, N., Desautels, A., Tousignant, M., Vanier, C., Lipp, O., Benkelfat, C., Rouleau, G., Turecki, G. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003) [Pubmed]
Why different rules are required for polygenic inheritance: lessons from studies of the DRD2 gene. Comings, D.E. Alcohol (1998) [Pubmed]
Electrophysiological assessment of impulsive behavior in healthy subjects. Fallgatter, A.J., Herrmann, M.J. Neuropsychologia. (2001) [Pubmed]
Interaction of nitric oxide and serotonin in aggressive behavior. Chiavegatto, S., Nelson, R.J. Hormones and behavior. (2003) [Pubmed]

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