Disease relevance of Borderline Personality Disorder

• OBJECTIVE: Divalproex sodium, an anticonvulsant and antimanic agent, has recently been studied for its antiaggressive effects in patients with brain injuries, dementia, and borderline personality disorder [1].
• They were more likely to be positive for markers of hepatitis C infection, to have a borderline personality disorder, antisocial personality disorder, or to have concurrent opiate or benzodiazepine dependence [2].
• Three distinct subcategories of the borderline personality disorder have been identified: history of no organicity, history of trauma, encephalitis, or epilepsy, and history of attentional deficit disorder/learning disabilities [3].

Psychiatry related information on Borderline Personality Disorder

• Using three sets of clinical criteria to define borderline personality disorder (BPD), P300 (P3) and other long-latency auditory event-related electroencephalographic potentials were measured in 22 subjects with BPD, 32 subjects with other personality disorders, 29 schizophrenics, 22 depressives, and 74 volunteer controls [4].
• BACKGROUND: High coincidence of childhood abuse, major depressive disorder (MDD), and posttraumatic stress disorder (PTSD) has been reported in patients with borderline personality disorder (BPD) [5].
• We administered a series of intravenous bolus doses of procaine hydrochloride to 31 subjects (7 with affective disorders, 17 with borderline personality disorder, and 7 healthy normal volunteers) [6].
• In Part II, we review the biology, genetics, and clinical course of borderline personality disorder (BPD), continuing to attend to the utility of a focus on fundamental dimensions of psychopathology [7].
• Bulimics with borderline comorbidity resembled recurrent suicide attempters with borderline personality disorder more closely in both psychological (anger, impulsive behavior) and biochemical characteristics (platelet 5-HT) than bulimics without borderline personality disorder [8].

High impact information on Borderline Personality Disorder

• Discovery of the monogenic disorder responsible for Huntington disease and understanding its pathogenesis can serve as a paradigm for unraveling the much more complex, polygenic disorders responsible for such psychiatric diseases as schizophrenia, manic depressive illness, and borderline personality disorder [9].
• The typical patient was a polydrug-abusing girl with a borderline personality disorder and a superimposed major depressive disorder [10].
• Efficacy of phenelzine and haloperidol in borderline personality disorder [11].
• Pharmacotherapy of borderline personality disorder. Alprazolam, carbamazepine, trifluoperazine, and tranylcypromine [12].
• Auditory P300 in borderline personality disorder and schizophrenia [4].

Chemical compound and disease context of Borderline Personality Disorder

• Impact of trait impulsivity and state aggression on divalproex versus placebo response in borderline personality disorder [13].
• The dexamethasone suppression test in patients with borderline personality disorders [14].
• Age at which trauma(s) occurred and a borderline personality disorder diagnosis had no significant main or interaction effects on cortisol suppression [15].
• CONCLUSIONS: No evidence of efficacy was found for continuation therapy with haloperidol in the treatment of borderline personality disorder other than in the treatment of irritability [16].
• Aripiprazole in the treatment of patients with borderline personality disorder: a double-blind, placebo-controlled study [17].

Biological context of Borderline Personality Disorder

• Bone mineral density, markers of bone turnover, and cytokines in young women with borderline personality disorder with and without comorbid major depressive disorder [18].
• Platelet alpha 2-adrenergic receptor binding sites in major depressive disorder and borderline personality disorder [19].
• 1. Eating disorders can be found in several psychiatric pathologies: schizophrenia, delusional disorder (somatic type), bipolar disorders, major depressive disorder, borderline personality disorder, generalized anxiety disorder, body dysmorphic disorder, somatization disorder and conversion disorder [20].

Gene context of Borderline Personality Disorder

• Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse [5].
• Male patients suffering from borderline personality disorder (n = 13), major depression (n = 13) or schizophrenia (n = 13) were investigated on several psychopathological (HDRS, BPRS) and neuroendocrinological (DST and TSH, PRL, GH responses to TRH) parameters [21].
• This study investigated the specificity of adult ADHD features in relation to patients with borderline personality disorder (BPD), a syndrome which shares some of its intrinsic features with ADHD and often co-occurs with ADHD [22].
• Homosexuality in patients with borderline personality disorder [23].
• Obsessive-compulsive disorder and borderline personality disorder [24].

Analytical, diagnostic and therapeutic context of Borderline Personality Disorder

• Homosexuality was 10 times more common among the men and six times more common among the women with borderline personality disorder than in the general population or in a depressed control group [25].
• Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder [26].
• EEG sleep, lithium transport, dexamethasone suppression, and monoamine oxidase activity in borderline personality disorder [27].

References