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MeSH Review


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Disease relevance of Ergotism


High impact information on Ergotism


Chemical compound and disease context of Ergotism

  • To our knowledge, this is the first report of clinical ergotism precipitated by clarithromycin-ergotamine interaction and suggests that, like other macrolide antibiotics, ergot preparations should be avoided in patients who are taking clarithromycin [1].
  • Cerebral ergotism under treatment with ergotamine and ritonavir [11].
  • Nitroprusside is the drug of choice in the treatment of acute vascular insufficiency from ergotism, but in a less urgent situation, prazosin has also been effective [12].
  • If the condition is left untreated, it is likely though by no means certain that the more traditional aspects of ergotism will evolve, although variable susceptibility and tolerance to ergotamine tartrate have been demonstrated [13].
  • Ergotism precipitated by erythromycin: a rare case of vasospasm [14].

Gene context of Ergotism


Analytical, diagnostic and therapeutic context of Ergotism


  1. Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction. Horowitz, R.S., Dart, R.C., Gomez, H.F. Arch. Intern. Med. (1996) [Pubmed]
  2. Pharmacokinetic drug interactions of macrolides. Periti, P., Mazzei, T., Mini, E., Novelli, A. Clinical pharmacokinetics. (1992) [Pubmed]
  3. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Dresser, G.K., Spence, J.D., Bailey, D.G. Clinical pharmacokinetics. (2000) [Pubmed]
  4. Ischaemic peripheral neuritis secondary to ergotism associated with ritonavir therapy. Phan, T.G., Agaliotis, D., White, G., Britton, W.J. Med. J. Aust. (1999) [Pubmed]
  5. Brachial artery stenosis secondary to ergotism and responsive to nifedipine. Borges, A.A., Lin, C.C., Jabaji, G.J., Thomas, W.L. Postgraduate medicine. (1986) [Pubmed]
  6. Sodium nitroprusside and epidural blockade in the treatment of ergotism. Andersen, P.K., Christensen, K.N., Hole, P., Juhl, B., Rosendal, T., Stokke, D.B. N. Engl. J. Med. (1977) [Pubmed]
  7. Ergotism related to concurrent administration of ergotamine tartrate and indinavir. Rosenthal, E., Sala, F., Chichmanian, R.M., Batt, M., Cassuto, J.P. JAMA (1999) [Pubmed]
  8. Ergotism as complication of thromboembolic prophylaxis with heparin and dihydroergotamine. Gatterer, R. Lancet (1986) [Pubmed]
  9. Nitroglycerin infusion for ergotism. Husum, B., Metz, P., Rasmussen, J.P. Lancet (1979) [Pubmed]
  10. Ergotism related to interaction between nelfinavir and ergotamine. Mortier, E., Pouchot, J., Vinceneux, P., Lalande, M. Am. J. Med. (2001) [Pubmed]
  11. Cerebral ergotism under treatment with ergotamine and ritonavir. Spiegel, M., Schmidauer, C., Kampfl, A., Sarcletti, M., Poewe, W. Neurology (2001) [Pubmed]
  12. Recognition and treatment of arterial insufficiency from cafergot. Wells, K.E., Steed, D.L., Zajko, A.B., Webster, M.W. J. Vasc. Surg. (1986) [Pubmed]
  13. Ergotamine tartrate dependency: features and possible mechanisms. Saper, J.R., Jones, J.M. Clinical neuropharmacology. (1986) [Pubmed]
  14. Ergotism precipitated by erythromycin: a rare case of vasospasm. Karam, B., Farah, E., Ashoush, R., Jebara, V., Ghayad, E. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2000) [Pubmed]
  15. A role for platelet-derived growth factor in drug-induced chronic ergotism? A case report. Pietrogrande, F., Caenazzo, A., Dazzi, F., Polato, G., Girolami, A. Angiology. (1995) [Pubmed]
  16. Saint Anthony's fire or carpal tunnel syndrome? (a case of iatrogenic ergotism). Fitzgerald, B. The Hand. (1978) [Pubmed]
  17. Clinical ergotism induced by ritonavir. Vila, A., Mykietiuk, A., Bonvehì, P., Temporiti, E., Urueña, A., Herrera, F. Scand. J. Infect. Dis. (2001) [Pubmed]
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