Disease relevance of Cyanosis

• Other findings were markedly different from those usually present in older children and adults with hypertrophic cardiomyopathy (e.g., right ventricular hypertrophy on the ECG and cyanosis) [1].
• In contrast to chicken NT which induced hypotension, hyperglycemia, increased vascular permeability, and cyanosis when injected intravenously into anesthetized rats, synthetic LANT-6 brought about primarily a hypertensive response and had little ability to promote hyperglycemia, increased vascular permeability, and cyanosis [2].
• In contrast to humans, term SERCA1-null mice had progressive cyanosis and gasping respiration and succumbed from respiratory failure shortly after birth [3].
• PTC syndrome as seen at the authors' institution has been an important and relatively common cause of congestive heart failure and cyanosis in the newborn [4].
• The myocardial profile of the cytosolic isozymes of creatine kinase is apparently not related to cyanosis in congenital heart disease [5].

Psychiatry related information on Cyanosis

• Affected infants may present with asymptomatic cyanosis, which can progress to dyspnea and lethargy or coma [6].

High impact information on Cyanosis

• Landmark article Sept 8, 1945: Cyanosis in infants caused by nitrates in well-water. By Hunter H. Comly [7].
• This condition should be suspected if cyanosis, clubbing, and a "normal" cardiac examination coexist and if the more common pulmonary and hematological causes of this triad have been excluded [8].
• Sox11-deficient mice died at birth from congenital cyanosis, likely resulting from heart defects [9].
• The addition of intrarenal artery heparin infusion resulted in greater improvement in early total blood flow rates and more uniformly progressive cyanosis and loss of turgor, but the diffuse initial morphologic injury suggested more uniform perfusion of injured areas [10].
• When induced by benzocaine anesthetic spray and other chemicals, it can result in cyanosis and life-threatening complications [11].

Chemical compound and disease context of Cyanosis

• Cyanosis, murmur, small volume pulses and prematurity gave information about prostaglandin-responsive defects [12].
• A 25-year-old woman taking usual doses of phenazopyridine developed her third clinically significant episode of cyanosis [13].
• Admission was more likely to occur when patients arrived during the week than at the weekend, when they had cyanosis or pulsus paradoxus, and after receiving parenteral treatment [14].
• Treatment with bleomycin resulted in failure to thrive, weight loss, and 30% mortality from nonpulmonary causes, as indicated by the lack of respiratory distress or cyanosis, during or shortly after the injection period [15].
• Studies were prompted by a case of aniline-induced methaemoglobinaemia in which two injections of methylene blue did not rapidly eliminate cyanosis and were followed by severe, delayed haemolysis [16].

Biological context of Cyanosis

• We report a case associated with an ostium secundum atrial septal defect and normal pulmonary vascular resistance, which resulted in severe episodic cyanosis [17].
• Pretreatment with the specific mast cell degranulating agent, compound 48/80, also blocked NT's ability to elevate plasma levels of histamine, LTB4 and LTC4 and prevented the increased hematocrit and cyanosis [18].
• This syndrome is characterized by generalized skeletal muscle rigidity, leading to an increase in body temperature, marked acidosis, hyperkaliaemia, cyanosis and elevation of lactate, carbon dioxide and the muscle enzyme creatine kinase (CK) in plasma [19].
• Methacholine challenge was stopped when clinical signs (coughing, wheezing, or cyanosis) or a drop of oxygen saturation (SPO2) of at least 5% or a drop of transcutaneous oxygen tension (PtcO2) of at least 0.8 kPa or an increase of resistance (RrsSO), of 50% by single occlusion technique were observed [20].
• In addition, dichromate produced cyanosis, which appeared during the period of the accelerated glycolysis and breakdown of creatinine phosphate [21].

Anatomical context of Cyanosis

• BACKGROUND: Superior vena cava syndrome is a rare, life-threatening clinical entity associated with occlusion of venous outflow from the head, neck, and upper extremities; this syndrome produces facial edema, cyanosis, dyspnea, and prominent neck veins, and is usually caused by intrathoracic neoplasms [22].
• The presumption of agenesis of the ductus arteriosus was made because there was no reduction in cyanosis following prostaglandin E1 treatment and no remnant of ductus arteriosus could be demonstrated by angiography at 19 h of age [23].
• Right superior vena cava draining predominantly into the left atrium causing cyanosis in a young child [24].
• Two of the three patients with pathological signs of Ammon's horn sclerosis had episodes of coma, covulsion, high fever and cyanosis in their past histories that might have portended the appearance of Ammon's horn sclerosis later in their lives [25].
• INTERVENTIONS AND RESULTS--Postoperative angiography in case 1 showed a remnant of a left inferior vena cava draining to the atrium to have become grossly dilated causing cyanosis, which resolved after redirection of this vessel and of the hepatic veins into the right pulmonary artery with an intra-atrial baffle [26].

Gene context of Cyanosis

• Among infants, increased pulmonary blood flow was associated with higher S100B levels before surgery than cyanosis [27].
• MAIN RESULTS: In infants with left-to-right shunts, soluble tumor necrosis factor receptor levels were significantly elevated as compared with infants with cyanosis (TNF-R1: 1.7 +/- 0.5 vs. 0.8 +/- 0.3 ng/mL; p =.0003; TNF-R2: 8.1 +/- 4.0 vs. 5.1 +/- 3.2 ng/mL; p =.049) [28].
• Edema, hypotension, cyanosis and flushing should alert one to the possibility of a neurotensin-secreting tumor [29].
• In hereditary cytochrome b5 deficiency, treatment is often directed at improving the poor cosmetic effect of persistent cyanosis with the minimum amount of drugs to give satisfactory clinical results [30].
• With biventricular repair, cyanosis and serum VEGF are normalized [31].

Analytical, diagnostic and therapeutic context of Cyanosis

• Ten minutes after administration of 125 mg ketamine im, she developed laboured breathing, cyanosis, and bilateral crepitations and arterial blood gas analysis showed PaO2 55 mmHg [32].
• Emergent cesarean section was considered but administration of intravenous methylene blue readily reversed the cyanosis and prevented the operation [33].
• We report the successful transcatheter closure of a large persistent left superior vena cava draining into the pulmonary venous circulation causing cyanosis in two patients who had previously undergone the Fontan operation utilizing the Gianturco Grifka vascular occlusion device [34].
• His physical examination revealed warm shock state, eruptions resembling that seen in systemic lupus erythematosus on his face and cyanosis in his fingers [35].
• One case of prilocaine induced toxic methemoglobinemia is presented and discussed to remind the practitioner that although rare, this condition can be life threatening, and should be considered in the differential diagnosis of cyanosis [36].

References