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Disease relevance of Cyanosis


Psychiatry related information on Cyanosis


High impact information on Cyanosis

  • Landmark article Sept 8, 1945: Cyanosis in infants caused by nitrates in well-water. By Hunter H. Comly [7].
  • This condition should be suspected if cyanosis, clubbing, and a "normal" cardiac examination coexist and if the more common pulmonary and hematological causes of this triad have been excluded [8].
  • Sox11-deficient mice died at birth from congenital cyanosis, likely resulting from heart defects [9].
  • The addition of intrarenal artery heparin infusion resulted in greater improvement in early total blood flow rates and more uniformly progressive cyanosis and loss of turgor, but the diffuse initial morphologic injury suggested more uniform perfusion of injured areas [10].
  • When induced by benzocaine anesthetic spray and other chemicals, it can result in cyanosis and life-threatening complications [11].

Chemical compound and disease context of Cyanosis

  • Cyanosis, murmur, small volume pulses and prematurity gave information about prostaglandin-responsive defects [12].
  • A 25-year-old woman taking usual doses of phenazopyridine developed her third clinically significant episode of cyanosis [13].
  • Admission was more likely to occur when patients arrived during the week than at the weekend, when they had cyanosis or pulsus paradoxus, and after receiving parenteral treatment [14].
  • Treatment with bleomycin resulted in failure to thrive, weight loss, and 30% mortality from nonpulmonary causes, as indicated by the lack of respiratory distress or cyanosis, during or shortly after the injection period [15].
  • Studies were prompted by a case of aniline-induced methaemoglobinaemia in which two injections of methylene blue did not rapidly eliminate cyanosis and were followed by severe, delayed haemolysis [16].

Biological context of Cyanosis


Anatomical context of Cyanosis

  • BACKGROUND: Superior vena cava syndrome is a rare, life-threatening clinical entity associated with occlusion of venous outflow from the head, neck, and upper extremities; this syndrome produces facial edema, cyanosis, dyspnea, and prominent neck veins, and is usually caused by intrathoracic neoplasms [22].
  • The presumption of agenesis of the ductus arteriosus was made because there was no reduction in cyanosis following prostaglandin E1 treatment and no remnant of ductus arteriosus could be demonstrated by angiography at 19 h of age [23].
  • Right superior vena cava draining predominantly into the left atrium causing cyanosis in a young child [24].
  • Two of the three patients with pathological signs of Ammon's horn sclerosis had episodes of coma, covulsion, high fever and cyanosis in their past histories that might have portended the appearance of Ammon's horn sclerosis later in their lives [25].
  • INTERVENTIONS AND RESULTS--Postoperative angiography in case 1 showed a remnant of a left inferior vena cava draining to the atrium to have become grossly dilated causing cyanosis, which resolved after redirection of this vessel and of the hepatic veins into the right pulmonary artery with an intra-atrial baffle [26].

Gene context of Cyanosis

  • Among infants, increased pulmonary blood flow was associated with higher S100B levels before surgery than cyanosis [27].
  • MAIN RESULTS: In infants with left-to-right shunts, soluble tumor necrosis factor receptor levels were significantly elevated as compared with infants with cyanosis (TNF-R1: 1.7 +/- 0.5 vs. 0.8 +/- 0.3 ng/mL; p =.0003; TNF-R2: 8.1 +/- 4.0 vs. 5.1 +/- 3.2 ng/mL; p =.049) [28].
  • Edema, hypotension, cyanosis and flushing should alert one to the possibility of a neurotensin-secreting tumor [29].
  • In hereditary cytochrome b5 deficiency, treatment is often directed at improving the poor cosmetic effect of persistent cyanosis with the minimum amount of drugs to give satisfactory clinical results [30].
  • With biventricular repair, cyanosis and serum VEGF are normalized [31].

Analytical, diagnostic and therapeutic context of Cyanosis


  1. Hypertrophic cardiomyopathy in infants: clinical features and natural history. Maron, B.J., Tajik, A.J., Ruttenberg, H.D., Graham, T.P., Atwood, G.F., Victorica, B.E., Lie, J.T., Roberts, W.C. Circulation (1982) [Pubmed]
  2. Isolation, biological and chemical characterization, and synthesis of a neurotensin-related hexapeptide from chicken intestine. Carraway, R.E., Ferris, C.F. J. Biol. Chem. (1983) [Pubmed]
  3. Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice. Pan, Y., Zvaritch, E., Tupling, A.R., Rice, W.J., de Leon, S., Rudnicki, M., McKerlie, C., Banwell, B.L., MacLennan, D.H. J. Biol. Chem. (2003) [Pubmed]
  4. Persistent transitional circulation. Roentgenographic findings in thirteen infants. Nielson, H.C., Riemenschneider, T.A., Jaffe, R.B. Radiology. (1976) [Pubmed]
  5. The myocardial profile of the cytosolic isozymes of creatine kinase is apparently not related to cyanosis in congenital heart disease. Kessler-Icekson, G., Birk, E., Schlesinger, H., Barhum, Y., Ad, N., Friedman, M., Vidne, B.A. Mol. Med. (1999) [Pubmed]
  6. Methemoglobinemia: nitrate toxicity in rural America. Kross, B.C., Ayebo, A.D., Fuortes, L.J. American family physician. (1992) [Pubmed]
  7. Landmark article Sept 8, 1945: Cyanosis in infants caused by nitrates in well-water. By Hunter H. Comly. Comly, H.H. JAMA (1987) [Pubmed]
  8. Isolated drainage of the superior vena cava into the left atrium in a 52-year-old man: a rare congenital malformation in the adult presenting with cyanosis, polycythemia, and an unsuccessful lung scan. Ezekowitz, M.D., Alderson, P.O., Bulkley, B.H., Dwyer, P.N., Watkins, L., Lappe, D.L., Greene, H.L., Becker, L.C. Circulation (1978) [Pubmed]
  9. Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Sock, E., Rettig, S.D., Enderich, J., Bösl, M.R., Tamm, E.R., Wegner, M. Mol. Cell. Biol. (2004) [Pubmed]
  10. Hyperacute renal allograft rejection in the primate. Intrarenal effects of heparin and associated net release of factor VIII activity and kallikrein activation. Busch, G.J., Kobayashi, K., Hollenberg, N.K., Birtch, A.G., Colman, R.W. Am. J. Pathol. (1975) [Pubmed]
  11. Reported adverse event cases of methemoglobinemia associated with benzocaine products. Moore, T.J., Walsh, C.S., Cohen, M.R. Arch. Intern. Med. (2004) [Pubmed]
  12. Application of information theory to decision analysis in potentially prostaglandin-responsive neonates. Danford, D.A., Gutgesell, H.P., McNamara, D.G. J. Am. Coll. Cardiol. (1986) [Pubmed]
  13. Phenazopyridine induced methaemoglobinaemia associated with decreased activity of erythrocyte cytochrome b5 reductase. Daly, J.S., Hultquist, D.E., Rucknagel, D.L. J. Med. Genet. (1983) [Pubmed]
  14. Assessment and management of asthma in an accident and emergency department. Reed, S., Diggle, S., Cushley, M.J., Sleet, R.A., Tattersfield, A.E. Thorax (1985) [Pubmed]
  15. Intravenous bleomycin does not alter the toxic effects of hyperoxia in rabbits. Matalon, S., Harper, W.V., Nickerson, P.A., Olszowka, J. Anesthesiology (1986) [Pubmed]
  16. Studies of the efficacy and potential hazards of methylene blue therapy in aniline-induced methaemoglobinaemia. Harvey, J.W., Keitt, A.S. Br. J. Haematol. (1983) [Pubmed]
  17. Intrapericardial diaphragmatic hernia, atrial septal defect, and severe episodic cyanosis. Shely, W.W., Loitz, R.D., Fox, A.H., Wells, W.J. Ann. Thorac. Surg. (1994) [Pubmed]
  18. Neurotensin elevates hematocrit and plasma levels of the leukotrienes, LTB4, LTC4, LTD4 and LTE4, in anesthetized rats. Carraway, R.E., Cochrane, D.E., Salmonsen, R., Muraki, K., Boucher, W. Peptides (1991) [Pubmed]
  19. Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia. Löscher, W., Witte, U., Fredow, G., Ganter, M., Bickhardt, K. Naunyn Schmiedebergs Arch. Pharmacol. (1990) [Pubmed]
  20. Safety and tolerability of methacholine challenge in infants with recurrent wheeze. Bez, C., Sach, G., Jarisch, A., Rosewich, M., Reichenbach, J., Zielen, S. The Journal of asthma : official journal of the Association for the Care of Asthma. (2003) [Pubmed]
  21. Acute toxic effect of sodium dichromate on metabolism. Kim, E., Na, K.J. Arch. Toxicol. (1990) [Pubmed]
  22. Recurrent transient superior vena cava-like syndrome possibly associated with megestrol acetate. Abulafia, O., Sherer, D.M. Obstetrics and gynecology. (1995) [Pubmed]
  23. Tetralogy of Fallot with absent ductus arteriosus and absent collateral pulmonary circulation: diagnostic and surgical implications during the neonatal period. Pahl, E., Muster, A.J., Ilbawi, M.N., DeLeon, S.Y. Pediatric cardiology. (1988) [Pubmed]
  24. Right superior vena cava draining predominantly into the left atrium causing cyanosis in a young child. Recto, M.R., Sobczyk, W.L., Yeh, T. Pediatric cardiology. (2004) [Pubmed]
  25. Pathological effect of seizures on the hippocampus in cases with temporal lobe epilepsy caused by brain tumors. Uesugi, H., Shimizu, H., Arai, N., Maehara, T., Mizutani, T., Kawai, K., Nakayama, H. Psychiatry and clinical neurosciences. (2002) [Pubmed]
  26. Increasing cyanosis early after cavopulmonary connection caused by abnormal systemic venous channels. Gatzoulis, M.A., Shinebourne, E.A., Redington, A.N., Rigby, M.L., Ho, S.Y., Shore, D.F. British heart journal. (1995) [Pubmed]
  27. A glial-derived protein, S100B, in neonates and infants with congenital heart disease: evidence for preexisting neurologic injury. Bokesch, P.M., Appachi, E., Cavaglia, M., Mossad, E., Mee, R.B. Anesth. Analg. (2002) [Pubmed]
  28. Endogenous nitric oxide and soluble tumor necrosis factor receptor levels are enhanced in infants with congenital heart disease. Buchhorn, R., Wessel, A., Hulpke-Wette, M., Bürsch, J., Werdan, K., Loppnow, H. Crit. Care Med. (2001) [Pubmed]
  29. Somatostatinomas, PPomas, neurotensinomas. Vinik, A.I., Strodel, W.E., Eckhauser, F.E., Moattari, A.R., Lloyd, R. Semin. Oncol. (1987) [Pubmed]
  30. Concise review: methemoglobinemia. Mansouri, A., Lurie, A.A. Am. J. Hematol. (1993) [Pubmed]
  31. Increased vascular endothelial growth factor in patients with cyanotic congenital heart diseases may not be normalized after a Fontan type operation. Suda, K., Matsumura, M., Miyanish, S., Uehara, K., Sugita, T., Matsumoto, M. Ann. Thorac. Surg. (2004) [Pubmed]
  32. Fulminant pulmonary edema after intramuscular ketamine. Pandey, C.K., Mathur, N., Singh, N., Chandola, H.C. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2000) [Pubmed]
  33. Metobromuron/metolachlor ingestion with late onset methemoglobinemia in a pregnant woman successfully treated with methylene blue. Yang, C.C., Hwang, S.F., Chou, M.M., Deng, J.F. J. Toxicol. Clin. Toxicol. (1995) [Pubmed]
  34. Transcatheter closure of large persistent left superior vena cava causing cyanosis in two patients post-Fontan operation utilizing the Gianturco Grifka vascular occlusion device. Recto, M.R., Elbl, F., Austin, E. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. (2001) [Pubmed]
  35. An idiopathic skin eruption resembling a butterfly rash in a septic patient with disseminated intravascular coagulation following bone marrow transplantation. Ontachi, Y., Asakura, H., Funada, H., Takami, A., Saito, M., Morishita, E., Yamazaki, M., Mizutani, T., Kaneda, M., Ito, T., Nakao, S. Blood Coagul. Fibrinolysis (2004) [Pubmed]
  36. Life-threatening toxic methemoglobinemia induced by prilocaine. Kreutz, R.W., Kinni, M.E. Oral Surg. Oral Med. Oral Pathol. (1983) [Pubmed]
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