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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Mediterranean Region

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Disease relevance of Mediterranean Region


High impact information on Mediterranean Region

  • Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1; MIM 254800) is an autosomal recessive disorder that occurs with a low frequency in many populations but is more common in Finland and the Mediterranean region [6].
  • It is inherited in an autosomal recessive fashion and found most frequently in the Mediterranean region and the Middle East. We report 2 related Irish families with clinically severe CAII deficiency in whom the gene mutation has been fully elucidated [7].
  • Among the 121 PCOS female subjects from the Mediterranean region, 15.7 and 2.5% displayed impaired glucose tolerance and type 2 diabetes, respectively [8].
  • Molecular diversity at the CYP2D6 locus in the Mediterranean region [9].
  • We analyzed the occurrence of the naphthalene degradation upper-pathway (nah) genes in the western Mediterranean region [2].

Associations of Mediterranean Region with chemical compounds

  • Specific IgM in serum and/or intrathecally produced anti-TOSV IgG were detected in seven patients, three residents from the Mediterranean region and the remainder four from the Region of Madrid [10].
  • P. judaica, on the other hand, is a very dominant pollen allergen of the Mediterranean region, sensitizing almost 80% of the allergic population [11].
  • These species collectively have colonized the Mediterranean region, tropical Africa, much of the Americas and hundreds of islands in the Pacific, Indian, and Atlantic oceans [12].
  • Durum wheat ( Triticum turgidum L. var durum) is mainly produced and consumed in the Mediterranean region; it is used to produce several specific end-products; such as local pasta, couscous and burghul [13].
  • In the Mediterranean region, the magnitude of these mechanisms are particularly significant, due to favorable climate conditions and to the presence of large cinnabar deposits that cross the whole region; all these synergic factors yield significant evasional fluxes of mercury from the surface water during most of the annual period [14].

Gene context of Mediterranean Region

  • An unexpected wide population variation of the G1733A polymorphism of the androgen receptor gene: data on the Mediterranean region [15].
  • Of 24 deficient subjects, 19 (79%) had the 563 T Mediterranean mutation.CONCLUSIONS: The frequency of G6PD enzyme deficiency appears to be low compared with those found in the malaria-endemic Mediterranean region of Turkey [16].
  • In this study, we analyse the HLA-DRB1 and DQB1 molecular diversity in three populations from the south of Tunisia--Berbers from Jerba, Berbers from Matmata and Arabs from Gabes--and we compare them to a large set of populations from the whole Mediterranean region [17].
  • When the levels of outdoor NO2 exposure rose, the prevalence of allergic rhinitis increased significantly in the Mediterranean region (OR = 1.38; 95% CI 1.12 to 1.69), but not in the subcontinental one (OR = 1.03; 95% CI 0.83 to 1.28) [18].
  • Nine Y-chromosome STRs were investigated in a male population sample from the Western Mediterranean region of Valencia (Eastern Spain) [19].


  1. High prevalence of Factor V Leiden mutation among healthy individuals and patients with deep venous thrombosis in Lebanon: is the eastern Mediterranean region the area of origin of this mutation? Taher, A., Khalil, I., Shamseddine, A., El-Ahdab, F., Bazarbachi, A. Thromb. Haemost. (2001) [Pubmed]
  2. Coexistence of two distinct copies of naphthalene degradation genes in Pseudomonas strains isolated from the western Mediterranean region. Ferrero, M., Llobet-Brossa, E., Lalucat, J., García-Valdés, E., Rosselló-Mora, R., Bosch, R. Appl. Environ. Microbiol. (2002) [Pubmed]
  3. Clonal spread of meropenem-resistant Acinetobacter baumannii strains in hospitals in the Mediterranean region and transmission to South-west Germany. Schulte, B., Goerke, C., Weyrich, P., Gröbner, S., Bahrs, C., Wolz, C., Autenrieth, I.B., Borgmann, S. J. Hosp. Infect. (2005) [Pubmed]
  4. Evidence of oxidative stress in erythrocyte phospholipid composition in the pathogenesis of familial Mediterranean fever (periodical disease). Karaguezyan, K.G., Haroutjunian, V.M., Mamiconyan, R.S., Hakobian, G.S., Nazaretian, E.E., Hovsepyan, L.M., Hoveyan, G.A., Gevorkian, E.M., Hovakimyan, S.S., Zakarian, A.E., Quinn, P.J. J. Clin. Pathol. (1996) [Pubmed]
  5. Genetically heterogeneous selective intestinal malabsorption of vitamin B12: founder effects, consanguinity, and high clinical awareness explain aggregations in Scandinavia and the Middle East. Tanner, S.M., Li, Z., Bisson, R., Acar, C., Oner, C., Oner, R., Cetin, M., Abdelaal, M.A., Ismail, E.A., Lissens, W., Krahe, R., Broch, H., Gräsbeck, R., de la Chapelle, A. Hum. Mutat. (2004) [Pubmed]
  6. Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1. Virtaneva, K., D'Amato, E., Miao, J., Koskiniemi, M., Norio, R., Avanzini, G., Franceschetti, S., Michelucci, R., Tassinari, C.A., Omer, S., Pennacchio, L.A., Myers, R.M., Dieguez-Lucena, J.L., Krahe, R., de la Chapelle, A., Lehesjoki, A.E. Nat. Genet. (1997) [Pubmed]
  7. Bone marrow transplantation corrects osteopetrosis in the carbonic anhydrase II deficiency syndrome. McMahon, C., Will, A., Hu, P., Shah, G.N., Sly, W.S., Smith, O.P. Blood (2001) [Pubmed]
  8. Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factors. Gambineri, A., Pelusi, C., Manicardi, E., Vicennati, V., Cacciari, M., Morselli-Labate, A.M., Pagotto, U., Pasquali, R. Diabetes (2004) [Pubmed]
  9. Molecular diversity at the CYP2D6 locus in the Mediterranean region. Fuselli, S., Dupanloup, I., Frigato, E., Cruciani, F., Scozzari, R., Moral, P., Sistonen, J., Sajantila, A., Barbujani, G. Eur. J. Hum. Genet. (2004) [Pubmed]
  10. Acute meningitis due to Toscana virus infection among patients from both the Spanish Mediterranean region and the region of Madrid. Echevarría, J.M., de Ory, F., Guisasola, M.E., Sánchez-Seco, M.P., Tenorio, A., Lozano, A., Córdoba, J., Gobernado, M. J. Clin. Virol. (2003) [Pubmed]
  11. Evaluation of cross-reactivity between Holoptelea integrifolia and Parietaria judaica. Sharma, S., Panzani, R.C., Gaur, S.N., Ariano, R., Singh, A.B. Int. Arch. Allergy Immunol. (2005) [Pubmed]
  12. Systematics, biogeography, and evolution of Hemidactylus geckos (Reptilia: Gekkonidae) elucidated using mitochondrial DNA sequences. Carranza, S., Arnold, E.N. Mol. Phylogenet. Evol. (2006) [Pubmed]
  13. A genetic linkage map of the Durum x Triticum dicoccoides backcross population based on SSRs and AFLP markers, and QTL analysis for milling traits. Elouafi, I., Nachit, M.M. Theor. Appl. Genet. (2004) [Pubmed]
  14. Temporal trends in gaseous mercury evasion from the Mediterranean seawaters. Ferrara, R., Mazzolai, B., Lanzillotta, E., Nucaro, E., Pirrone, N. Sci. Total Environ. (2000) [Pubmed]
  15. An unexpected wide population variation of the G1733A polymorphism of the androgen receptor gene: data on the Mediterranean region. Esteban, E., Via, M., González-Pérez, E., Santamaría, J., Dugoujon, J.M., Vona, G., Harich, N., Luna, F., Saetta, A.A., Bissar, N., Moral, P. Am. J. Hum. Biol. (2005) [Pubmed]
  16. Incidence and molecular analysis of glucose-6-phosphate dehydrogenase deficiency in the province of Denizli, Turkey. Keskin, N., Ozdes, I., Keskin, A., Acikbas, I., Bagci, H. Med. Sci. Monit. (2002) [Pubmed]
  17. HLA class II genetic diversity in southern Tunisia and the Mediterranean area. Abdennaji Guenounou, B., Loueslati, B.Y., Buhler, S., Hmida, S., Ennafaa, H., Khodjet-Elkhil, H., Moojat, N., Dridi, A., Boukef, K., Ben Ammar Elgaaied, A., Sanchez-Mazas, A. Int. J. Immunogenet. (2006) [Pubmed]
  18. The impact of climate and traffic-related NO2 on the prevalence of asthma and allergic rhinitis in Italy. de Marco, R., Poli, A., Ferrari, M., Accordini, S., Giammanco, G., Bugiani, M., Villani, S., Ponzio, M., Bono, R., Carrozzi, L., Cavallini, R., Cazzoletti, L., Dallari, R., Ginesu, F., Lauriola, P., Mandrioli, P., Perfetti, L., Pignato, S., Pirina, P., Struzzo, P. Clin. Exp. Allergy (2002) [Pubmed]
  19. Y-chromosome STR haplotypes from a Western Mediterranean population sample. Aler, M., Salas, A., Sánchez-Diz, P., Murcia, E., Carracedo, A., Gisbert, M. Forensic Sci. Int. (2001) [Pubmed]
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