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MeSH Review:

Familial Mediterranean Fever

Salinovich, O. et al., Gogus, F. et al., Swissa, M. et al., Duzova, A. et al., Mulley, J. et al., et al.

Chae, Komarow, Cheng, Wood, Raben, Liu, Kastner, Korkmaz, Colak, Alatas, Ozarslan, Ergül, Duzova, Ozaltin, Ozon, Besbas, Topaloglu, Ozen, Bakkaloglu, Mulley, Saar, Hewitt, Rüschendorf, Phillips, Colley, Sillence, Reis, Wilson, Espinosa, Arostegui, Plaza, Rius, Cervera, Yagüe, Font, Chou, Miner, Drew,

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Disease relevance of Familial Mediterranean Fever

The clinical features are similar to the disorder previously described as familial Hibernian fever, and they differ from familial Mediterranean fever (FMF) in that FPF episodes usually do not respond to colchicine and FPF is not associated with amyloidosis [1].
Episodes of fever, serositis, and arthritis in familial Mediterranean fever (FMF) suggested circulating mediators of acute inflammation (e.g., neutrophil activation) [2].
We describe data on a 7-year-old girl with congenital dyserythropoietic anemia (CDA), who also had familial Mediterranean fever (FMF) [3].
OBJECTIVE: Familial Mediterranean fever (FMF) is characterized by recurrent episodes of peritonitis, pleuritis, and synovitis [4].
Thus these results support the concept that equine infectious anemia virus is indeed capable of relatively rapid genomic variations during replication, some of which result in altered glycoprotein structures and antigenic variants which are responsible for the unique periodic disease nature observed in persistently infected animals [5].

High impact information on Familial Mediterranean Fever

Familial Mediterranean fever (FMF; MIM 249100) is an autosomal recessive disease characterized by recurrent attacks of fever with synovial, pleural or peritoneal inflammation [6].
Familial Mediterranean fever (FMF) is an inherited disorder characterized by recurrent episodes of fever and inflammation [7].
PURPOSE: The pleiotropic inflammatory effects of tumor necrosis factor (TNF) prompted a study of this cytokine in familial Mediterranean fever (FMF), a recurrent polyserositis of unknown etiology [8].
A patient with AIDS and cytomegalovirus (CMV) retinitis received ganciclovir and foscarnet for 20 and 5 months, respectively, with evidence of periodic disease progression [9].
OBJECTIVES: Crohn's disease (CD) has been reported to be more frequent among non-Ashkenazi Jewish patients suffering from familial Mediterranean fever (FMF) [10].

Chemical compound and disease context of Familial Mediterranean Fever

We have previously demonstrated an altered pattern of tumor necrosis factor (TNF) secretion in patients with familial Mediterranean fever (FMF) [11].
Sera samples of 168 patients with familial Mediterranean fever (FMF) and their 184 first degree relatives were analyzed for the presence of autoantibodies to ssDNA, dsDNA, poly (I), poly (G), cardiolipin, histones, RNP and Ro(SSA), using an enzyme linked immunosorbent assay (ELISA) [12].
OBJECTIVE: To study cortisol, adrenocorticotropic hormone and C-reactive protein responses to specific stimuli in familial Mediterranean fever (FMF) [13].
It is possible that the increase in C4 was due to the macrophages which are always present in the infiltrates of periodic disease [14].
A trial of diphenylhydantoin in periodic disease (familial Mediterranean fever) in Egyptian children [15].

Biological context of Familial Mediterranean Fever

Genetic linkage study of familial Mediterranean fever (FMF) to 16p13.3 and evidence for genetic heterogeneity in the Turkish population [16].
OBJECTIVES: To study the phenotype/genotype correlations in Arab patients with familial Mediterranean fever (FMF) [17].
To assess the pharmacokinetics of serum colchicine in patients with familial Mediterranean fever (FMF) with renal impairment [18].
The aim of this study was to evaluate bone mineral content (BMC), serum and urinary bone turnover parameters in patients with familial Mediterranean fever (FMF), an autosomal recessive disease characterized by recurrent episodes of inflammation of serous membranes [19].

Anatomical context of Familial Mediterranean Fever

Patients with familial Mediterranean fever (FMF) who were part of a double-blind trial of daily colchicine as prophylaxis for their disease had leukocyte functions studied while receiving colchicine or placebo [20].
OBJECTIVE: To investigate the expression of the familial Mediterranean fever (FMF) gene (MEFV) in human synovial fibroblasts [21].
We have previously reported a suppressor cell deficiency in four patients with familial Mediterranean fever (FMF) [22].
Central nervous system (CNS) manifestations of familial Mediterranean fever (FMF) are extremely rare [23].
OBJECTIVE: Familial Mediterranean Fever (FMF) is an autoinflammatory periodic disorder characterized by febrile and painful attacks due to inflammation involving the serosal membranes [24].

Gene context of Familial Mediterranean Fever

Eight of the common familial Mediterranean fever (FMF) gene MEFV mutations were excluded [25].
OBJECTIVE: Mutations in the MEFV and the type 1 TNF receptor (TNFRSF 1A) genes have recently been linked to familial Mediterranean fever (FMF) and TNF receptor-associated periodic syndrome (TRAPS), respectively [26].
METHODS: Peripheral blood mononuclear cells from patients with Behçet's syndrome (BS), rheumatoid arthritis (RA), familial Mediterranean fever (FMF) and healthy controls (HC) were incubated with 100 ng/ml phorbol myristate acetate (PMA) and MSU at different dosages (25-500 microg/ml) [27].
The most common arthritic involvement in familial Mediterranean fever (FMF) is acute recurrent monoarthritis; however, sometimes spondyloarthropathy-like findings or typical ankylosing spondylitis may also ensue [28].
AIMS: To evaluate the levels of endogenous interferon-gamma (IFN-gamma) in patients with familial Mediterranean fever (FMF) [29].

Analytical, diagnostic and therapeutic context of Familial Mediterranean Fever

In addition, 22 patients with familial Mediterranean fever (FMF) during the active period and 35 healthy children were included in the study as control groups [30].
The presence of autoantibodies in our familial Mediterranean fever (FMF) patients was investigated using various immunological techniques [31].
Lactose malabsorption was assessed by the lactose breath test in 23 patients with familial Mediterranean fever (FMF) receiving colchicine for 0.25-15 years (mean 3.16) [32].
The second patient with amyloid nephropathy due to familial Mediterranean fever (FMF) showed no impairment of graft function 24 months after transplantation [33].

References

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