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Disease relevance of CD-I

  • When Arthrobacter sp. BA-5-17 was grown on benzamide, the bacterium synthesized four different catechol 1,2-dioxygenase (CD, EC isozymes (CD-I, II, III-1, and III-2) [1].

High impact information on CD-I

  • Our findings suggest a model in which the two conserved regions of the catalytic domain, CD I and CD II, contribute to the formation of a UDP-GlcNAc-binding pocket that catalyzes the transfer of O-GlcNAc to substrate proteins [2].
  • OBJECTIVES: Thus, in the present study, we assessed a possible role for noradrenaline in the behavioural response to the non-competitive NMDA receptor anatgonist, MK-801, in male CD-I mice [3].
  • CONCLUSIONS: In conclusion, from the present research, it is evident that NMDA glutamate and nicotinic acetylcholine receptor systems interact in modulating memory consolidation in CD I mice [4].
  • The catA genes catA1 and catA2 encoding CD I and CD II, respectively, were cloned from a gene library of this bacterium [5].
  • The aniline-assimilating bacterium Frateuria species ANA-18 produced two catechol 1,2-dioxygenases, CD I and CD II, and two muconate cycloisomerases, MC I and MC II [5].

Biological context of CD-I

  • MATERIALS AND METHODS: ICR (CD-I) mice were injected subcutaneously with Methylene blue at 0 (vehicle), 5, 30, 50, 60 or 85 mg/Kg on gestation days 15.5 and 16 (plug day = gestation day 0) [6].

Anatomical context of CD-I

  • Specimens were obtained from 3 days-old CD-I mice and mandibles were carefully dissected under constant irrigation and immediately fixed in 10% neutral buffered formalin for light microscopy [7].

Associations of CD-I with chemical compounds

  • Low-dose, chronic administration of the synthetic glucocorticoid, dexamethasone, to male CD-I rats in the drinking water or by osmotic minipumps implanted subcutaneously after supralethal irradiation of the kidneys (20 Gy) was studied [8].
  • Calcitriol inhibited (80-90%) IL-I induced CD-I mouse thymocyte proliferation, whereas 25-OH-D3 was ineffective [9].

Gene context of CD-I

  • The spf GS activity remained constant from 28 to 56 days, whereas the CD-I GS activity decreased [10].
  • To avoid the use of lectins, thymocytes from CD-I Swiss mice were chosen, which proliferate in response to Interleukin-I (IL-I) or IL-2 without the addition of lectins [9].


  1. Purification and characterization of four catechol 1,2-dioxygenase isozymes from the benzamide-assimilating bacterium Arthrobacter species BA-5-17. Murakami, S., Wang, C.L., Naito, A., Shinke, R., Aoki, K. Microbiol. Res. (1998) [Pubmed]
  2. Mutational analysis of the catalytic domain of O-linked N-acetylglucosaminyl transferase. Lazarus, B.D., Roos, M.D., Hanover, J.A. J. Biol. Chem. (2005) [Pubmed]
  3. Modulation of MK-801-induced behaviour by noradrenergic agents in mice. Harkin, A., Morris, K., Kelly, J.P., O'Donnell, J.M., Leonard, B.E. Psychopharmacology (Berl.) (2001) [Pubmed]
  4. Effects of MK-801 and nicotine combinations on memory consolidation in CD1 mice. Ciamei, A., Aversano, M., Cestari, V., Castellano, C. Psychopharmacology (Berl.) (2001) [Pubmed]
  5. Cloning and sequence analysis of two catechol-degrading gene clusters from the aniline-assimilating bacterium Frateuria species ANA-18. Murakami, S., Takashima, A., Takemoto, J., Takenaka, S., Shinke, R., Aoki, K. Gene (1999) [Pubmed]
  6. The soluble guanylate cyclase inhibitor methylene blue evokes preterm delivery and fetal growth restriction in a mouse model. Tiboni, G.M., Giampietro, F., Lamonaca, D. In Vivo (2001) [Pubmed]
  7. Investigation of the role of Von Korff fibers during murine dentinogenesis. Shroff, B., Thomas, H.F. Journal de biologie buccale. (1992) [Pubmed]
  8. Effects of dexamethasone on the development of radiation nephropathy in the rat. Geraci, J.P., Taylor, D.A., Mariano, M.S., Jackson, K.L. Radiat. Res. (1992) [Pubmed]
  9. 1,25-Dihydroxyvitamin D3 (calcitriol) suppresses IL-2 induced murine thymocyte proliferation. Haq, A.U. Thymus (1986) [Pubmed]
  10. Developmental study of hepatic glutamine synthetase in a mouse model of congenital hyperammonemia. Skarpetas, A., Mawal, Y., Qureshi, I.A. Biochem. Mol. Biol. Int. (1997) [Pubmed]
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