Disease relevance of Fasciolidae

• Albendazole (10 mg/kg of body weight) was administered as a drench suspension or as a feed additive to 24 cattle with naturally acquired infections of Fasciola hepatica and Fascioloides magna [1].

High impact information on Fasciolidae

• A band detected by EITB using a densitometer in the area corresponding to 26 kDa reacted with rabbit anti-fresh fluke antigen and infected cattle sera but not with fluke-negative rabbit sera, rabbit anti-Fasciola hepatica egg sera, Fascioloides magna positive or negative cattle sera [2].
• Monoclonal antibody 179.57 cross-reacted with Fascioloides magna, A. magna, S. subtriquetrus, H. contortus, SLE, and BLE, but not with BSA, BVDV, or MDBK cells [3].
• Efficacy of triclabendazole against experimentally induced Fascioloides magna infections in sheep [4].
• Activity of closantel against experimentally induced Fascioloides magna infection in sheep [5].
• The treatment of Fasciolopsis buski infection in children: a comparison of thiabendazole, mebendazole, levamisole, pyrantel pamoate, hexylresorcinol and tetrachloroethylene [6].

Associations of Fasciolidae with chemical compounds

• Efficacy of clorsulon and albendazole against Fascioloides magna in naturally infected white-tailed deer [7].
• The efficacy of closantel against Fascioloides magna in sheep [8].
• Parenteral infection of white-tailed deer (Odocoileus virginianus) with metacercariae of Fasciola hepatica and Fascioloides magna [9].
• Sheep experimentally infected with Fascioloides magna were used in a controlled study to determine the flukicide activity of different doses of albendazole (methyl [5(propylthio)-1H-benzimidazol-2-yl] carbamate) [10].
• Fasciolopsis buski was killed by 10(-3) M oxyclozanide but at this concentration the remaining compounds only caused reduced activity [11].

Gene context of Fasciolidae

• With histochemical detection of NADPH-d, the presence of NOS is demonstrated in the digenetic trematode, Fasciolopsis buski [12].

References