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Chemical Compound Review

Closantel     N-[5-chloro-4-[(4- chlorophenyl)-cyano...

Synonyms: Closantelum, CHEMBL12131, SureCN116617, AC-277, CCRIS 9345, ...
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Disease relevance of Closantel


High impact information on Closantel

  • Closantel treatment induced lysosomal fusion of the E. chaffeensis inclusion in a human monocytic leukemia cell line, THP-1 cells, implying that functional TCSs are essential in preventing lysosomal fusion of the E. chaffeensis inclusion compartment [6].
  • Consequently, the plasma kinetics of closantel reliably reflect its depletion from tissues [7].
  • The relative bioavailability of 50% of oral closantel can partly be explained by incomplete absorption [7].
  • The distribution of closantel to tissues was limited by its high protein binding [7].
  • Closantel binds specifically to ovine serum albumin (K(a) of 9. 3x10(6)M(-1)) at site I, the warfarin/phenylbutazone binding site of albumin Closantel also binds to invertebrate haemocyanin and haemolymph [8].

Chemical compound and disease context of Closantel


Biological context of Closantel


Anatomical context of Closantel


Associations of Closantel with other chemical compounds


Gene context of Closantel

  • The method was applied to the determination of closantel in plasma and tissue samples, purified by a solid-phase extraction with C18 cartridges [21].

Analytical, diagnostic and therapeutic context of Closantel


  1. Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cheng, Z., Kumagai, Y., Lin, M., Zhang, C., Rikihisa, Y. Cell. Microbiol. (2006) [Pubmed]
  2. Lymphotropic antifilarial agents derived from closantel and chlorambucil. Loiseau, P.M., Bourass, J., Letourneux, Y. Int. J. Parasitol. (1997) [Pubmed]
  3. Activity of closantel in the prevention of Gasterophilus and Strongylus vulgaris larval infections in equine foals and yearlings. Guerrero, J., Newcomb, K., Seibert, B.P., Michael, B.F. Am. J. Vet. Res. (1985) [Pubmed]
  4. Closantel intoxication in a dog. McEntee, K., Grauwels, M., Clercx, C., Henroteaux, M. Veterinary and human toxicology. (1995) [Pubmed]
  5. Optic neuropathy and retinopathy in closantel toxicosis of sheep and goats. Gill, P.A., Cook, R.W., Boulton, J.G., Kelly, W.R., Vanselow, B., Reddacliff, L.A. Aust. Vet. J. (1999) [Pubmed]
  6. Biochemical activities of three pairs of Ehrlichia chaffeensis two-component regulatory system proteins involved in inhibition of lysosomal fusion. Kumagai, Y., Cheng, Z., Lin, M., Rikihisa, Y. Infect. Immun. (2006) [Pubmed]
  7. The metabolism and fate of closantel (Flukiver) in sheep and cattle. Michiels, M., Meuldermans, W., Heykants, J. Drug Metab. Rev. (1987) [Pubmed]
  8. The binding of closantel to ovine serum albumin, and homogenate fractions of Haemonchus contortus. Rothwell, J.T., Lacey, E., Sangster, N.C. Int. J. Parasitol. (2000) [Pubmed]
  9. Comparative anthelmintic activity of strategic sustained low-level administration of albendazole in feed pellets compared to single doses of closantel and tetramisole against natural ovine parasitic gastroenteritis. Khan, F.A., Sanyal, P.K., Swarnkar, C.P., Singh, D., Bhagwan, P.S. Tropical animal health and production. (1999) [Pubmed]
  10. Metabolic studies on the new fasciolicidal drug, closantel. Kane, H.J., Behm, C.A., Bryant, C. Mol. Biochem. Parasitol. (1980) [Pubmed]
  11. Haemonchus contortus: the uptake and metabolism of closantel. Rothwell, J., Sangster, N. Int. J. Parasitol. (1997) [Pubmed]
  12. The effects of closantel treatment on the ultrastructure of Haemonchus contortus. Rothwell, J.T., Sangster, N.C. Int. J. Parasitol. (1996) [Pubmed]
  13. Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics. Lanusse, C.E., Prichard, R.K. Vet. Parasitol. (1993) [Pubmed]
  14. The effect of a parenteral ivermectin/closantel injection on the growth and reproductive development of early immature Fasciola hepatica in cattle. Hanna, R.E., Cromie, L., Taylor, S.M., Couper, A. Vet. Parasitol. (2006) [Pubmed]
  15. How anthelmintics help us to understand helminths. Vanden Bossche, H. Parasitology (1985) [Pubmed]
  16. Comparative in vitro effects of closantel and selected beta-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells. Bacon, J.A., Ulrich, R.G., Davis, J.P., Thomas, E.M., Johnson, S.S., Conder, G.A., Sangster, N.C., Rothwell, J.T., McCracken, R.O., Lee, B.H., Clothier, M.F., Geary, T.G., Thompson, D.P. J. Vet. Pharmacol. Ther. (1998) [Pubmed]
  17. Glutathione S-transferases as markers of salicylanilide resistance in isolates of Fasciola hepatica. Miller, C.M., Howell, M.J., Boray, J.C. Int. J. Parasitol. (1994) [Pubmed]
  18. Efficacy of closantel plus albendazole liquid suspension against natural infection of gastrointestinal parasites in camels. Al-Qudah, K.M., Sharif, L.A., Al-Rawashdeh, O.F., Al-Ani, F.K. Vet. Parasitol. (1999) [Pubmed]
  19. Comparative efficacy of closantel and triclabendazole against Fasciola hepatica in experimentally infected sheep. Maes, L., Vanparijs, O., Lauwers, H., Deckers, W. Vet. Rec. (1990) [Pubmed]
  20. Comparison of the activity of some fasciolicides against immature liver fluke in calves. Dobbins, S.E., Wellington, A.C. Vet. Rec. (1982) [Pubmed]
  21. Determination of closantel residues in plasma and tissues by high-performance liquid chromatography with fluorescence detection. Stoev, G. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
  22. Kinetics of expulsion of Haemonchus contortus from sheep and jirds after treatment with closantel. Rothwell, J.T., Sangster, N.C., Conder, G.A., Dobson, R.J., Johnson, S.S. Int. J. Parasitol. (1993) [Pubmed]
  23. Quantitative determination of Closantel residues in milk by high-performance liquid chromatography with fluorescence detection. Stoev, G., Dakova, T., Michailova, A. Journal of chromatography. A. (1999) [Pubmed]
  24. Strategic use of moxidectin or closantel in combination with levamisole in the control of nematodes of sheep in the highlands of central Kenya. Maingi, N., Munyua, W.K., Gichigi, M.N. Acta Trop. (2002) [Pubmed]
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