The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Antibody-Dependent Enhancement

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Antibody-Dependent Enhancement


High impact information on Antibody-Dependent Enhancement

  • The administration of a fourth dose resulted in homologous neutralizing activity in sera from 5 to 24 subjects (21%; CI, 7% to 37%) as well as in complement-mediated antibody-dependent enhancement in sera from 6 of 24 subjects (25%; CI, 10% to 42%) [5].
  • Macrophages and monocytes have been associated with human RRV disease, and previous studies have shown that RRV is capable of infecting macrophages via both a natural virus receptor and by Fc receptor-mediated antibody-dependent enhancement (ADE) [6].
  • Levels of B19-DNA and B19-NS1 mRNA transcription increased in the presence of anti-B19 IgG antibodies, but this effect decreased in the presence of anti-Fc receptor antibodies, showing antibody-dependent enhancement by B19 infection [7].
  • This study is the first to suggest B19 infection of nonerythroid lineage cells with antibody-dependent enhancement [7].
  • In this study it is demonstrated that complement-mediated antibody-dependent enhancement (C'-ADE) of HIV-1 infection in vitro is blocked by murine monoclonal antibodies to CD4 and complement receptor type 2 (CR2) while HIV-1 infection in the absence of C'-ADE is blocked by anti-CD4 but not anti-CR2 monoclonal antibodies [8].

Anatomical context of Antibody-Dependent Enhancement


Gene context of Antibody-Dependent Enhancement


  1. The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells. Homsy, J., Meyer, M., Tateno, M., Clarkson, S., Levy, J.A. Science (1989) [Pubmed]
  2. Human IgG Fc receptor II mediates antibody-dependent enhancement of dengue virus infection. Littaua, R., Kurane, I., Ennis, F.A. J. Immunol. (1990) [Pubmed]
  3. Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement. Corapi, W.V., Darteil, R.J., Audonnet, J.C., Chappuis, G.E. J. Virol. (1995) [Pubmed]
  4. Two receptors are required for antibody-dependent enhancement of human immunodeficiency virus type 1 infection: CD4 and Fc gamma R. Takeda, A., Sweet, R.W., Ennis, F.A. J. Virol. (1990) [Pubmed]
  5. The safety and immunogenicity of a human immunodeficiency virus type 1 (HIV-1) recombinant gp160 candidate vaccine in humans. NIAID AIDS Vaccine Clinical Trials Network. Dolin, R., Graham, B.S., Greenberg, S.B., Tacket, C.O., Belshe, R.B., Midthun, K., Clements, M.L., Gorse, G.J., Horgan, B.W., Atmar, R.L. Ann. Intern. Med. (1991) [Pubmed]
  6. Specific ablation of antiviral gene expression in macrophages by antibody-dependent enhancement of Ross River virus infection. Lidbury, B.A., Mahalingam, S. J. Virol. (2000) [Pubmed]
  7. Human parvovirus B19 infection of monocytic cell line U937 and antibody-dependent enhancement. Munakata, Y., Kato, I., Saito, T., Kodera, T., Ishii, K.K., Sasaki, T. Virology (2006) [Pubmed]
  8. Complement-mediated antibody-dependent enhancement of HIV-1 infection requires CD4 and complement receptors. Robinson, W.E., Montefiori, D.C., Mitchell, W.M. Virology (1990) [Pubmed]
  9. Neutralizing and enhancing activities of human respiratory syncytial virus-specific antibodies. Gimenez, H.B., Chisholm, S., Dornan, J., Cash, P. Clin. Diagn. Lab. Immunol. (1996) [Pubmed]
  10. Dengue 2 virus enhancement in asthmatic and non asthmatic individual. Guzman, M.G., Kouri, G., Soler, M., Bravo, J., Rodríguez de La Vega, A., Vazquez, S., Mune, M. Mem. Inst. Oswaldo Cruz (1992) [Pubmed]
  11. Tumor necrosis factor alpha levels in plasma and whole-blood culture in dengue-infected patients: relationship between virus detection and pre-existing specific antibodies. Hober, D., Nguyen, T.L., Shen, L., Ha, D.Q., Huong, V.T., Benyoucef, S., Nguyen, T.H., Bui, T.M., Loan, H.K., Le, B.L., Bouzidi, A., De Groote, D., Drouet, M.T., Deubel, V., Wattré, P. J. Med. Virol. (1998) [Pubmed]
  12. Antibody dependent cell-mediated cytotoxicity using hepatocellular carcinoma reactive monoclonal antibody. Kuwata, T., Haruta, I., Hasegawa, K., Yamauchi, K., Hayashi, N. J. Gastroenterol. Hepatol. (1998) [Pubmed]
WikiGenes - Universities