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Disease relevance of Podophyllum


High impact information on Podophyllum

  • Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans [3].
  • A semi-purified extract of low-altitude Podophyllum hexandrum (REC-2001) containing a relatively low content of podophyllotoxin (3.25 %) exhibited potent antioxidant ability in lipid media (at 1000 microg/mLagainst 0.25 kGy) and significant (p < 0.05) hydroxyl ion scavenging potential (78.83 % at 500 microg/mL) [4].
  • Rehydration of powdered tissues of Podophyllum peltatum L. prior to extraction with an organic solvent allows endogenous beta-glucosidases to hydrolyze lignan 4-O-beta-D-glucosides in situ and increase the yield of podophyllotoxin [5].
  • Higher-cost modalities are cryotherapy ($951), trichloroacetic acid ($986), imiquimod ($1255), podophyllum resin ($1632), and interferon alfa-2b ($6665) [6].
  • A variety of treatment methods, including mental suggestion, local 5-fluorouracil, podophyllum, electrosurgery, and cryotherapy, has been used with varying success [7].

Biological context of Podophyllum


Anatomical context of Podophyllum

  • Tween80, the detergent included in the anti-inflammatory drug Proresid, containing podophyllum lignan derivatives, also inhibited lymphocyte proliferation in a dose-dependent manner [9].

Associations of Podophyllum with chemical compounds

  • An API-LC/MS/MS method was developed for the identification of the medicinal herb Podophyllum emodi based on the profile of its aryltetrahydronapthalene and related lignan marker compounds [10].
  • The patient was a 17-year-old female Indian who had received some 3 to 8 cc of a 20 percent mixture of podophyllum resin in compound tincture of benzoin (approximately equal to 0.4 gm of podophylotoxin) as an application to her vulvar condylomata [11].
  • Dinitrochlorobenzene was used to eradicate lesions that had been resistant to treatment with podophyllum resin [12].
  • These are based on the chemically modified structures of the naturally occurring podophyllum lignan, diphyllin [13].
  • The aryl tetralin lignans are synthesized by Podophyllum sps. and are in great demand worldwide due to their use in synthesis of topoisomerase inhibitors [14].

Gene context of Podophyllum


Analytical, diagnostic and therapeutic context of Podophyllum

  • The purpose of our research was to design and develop a sensitive immunoassay for the natural Podophyllum lignan, podophyllotoxin [1], which is the precursor of the anti-cancer drugs etoposide [2] and teniposide [3] [19].
  • RESULTS: Podophyllum Theta, Cina 30 and Santoninum 30 reduced the larval population in the studied mice by 68.14%, 84.10% and 81.20%, respectively, as compared to the untreated control group [17].


  1. Laryngeal papilloma: results of treatment with the CO2 laser and podophyllum. Dedo, H.H., Jackler, R.K. The Annals of otology, rhinology, and laryngology. (1982) [Pubmed]
  2. Podophyllotoxin for condylomata acuminata eradication. Clinical and experimental comparative studies on Podophyllum lignans, colchicine and 5-fluorouracil. von Krogh, G. Acta dermato-venereologica. Supplementum. (1981) [Pubmed]
  3. Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans. Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G., Kang, C. J. Biol. Chem. (2005) [Pubmed]
  4. Protection of the hemopoietic system by Podophyllum hexandrum against gamma radiation-induced damage. Sagar, R.K., Chawla, R., Arora, R., Singh, S., Krishna, B., Sharma, R.K., Puri, S.C., Singh, P., Kumar, R., Sharma, A.K., Singh, S., Prasad, J., Gupta, V., Ahmed, B., Dhar, K.L., Khan, H.A., Gupta, M.L., Qazi, G.N. Planta Med. (2006) [Pubmed]
  5. High yield of podophyllotoxin from leaves of Podophyllum peltatum by in situ conversion of podophyllotoxin 4- O-beta-D-glucopyranoside. Canel, C., Dayan, F.E., Ganzera, M., Khan, I.A., Rimando, A., Burandt, C.L., Moraes, R.M. Planta Med. (2001) [Pubmed]
  6. Direct medical costs for surgical and medical treatment of condylomata acuminata. Alam, M., Stiller, M. Archives of dermatology. (2001) [Pubmed]
  7. Carbon dioxide laser surgery in treatment of condyloma. Hahn, G.A. Am. J. Obstet. Gynecol. (1981) [Pubmed]
  8. Antioxidant activity of fractionated extracts of rhizomes of high-altitude Podophyllum hexandrum: role in radiation protection. Chawla, R., Arora, R., Kumar, R., Sharma, A., Prasad, J., Singh, S., Sagar, R., Chaudhary, P., Shukla, S., Kaur, G., Sharma, R.K., Puri, S.C., Dhar, K.L., Handa, G., Gupta, V.K., Qazi, G.N. Mol. Cell. Biochem. (2005) [Pubmed]
  9. Inhibition of ConA-induced proliferative response in human lymphocytes by podophyllotoxin and a detergent, Tween80. Månsson, B., Geborek, P., Hallberg, T., Sturfelt, G. Clinical and experimental rheumatology. (1988) [Pubmed]
  10. Identification and characterization of Podophyllum emodi by API-LC/MS/MS. Wong, S.K., Tsui, S.K., Kwan, S.Y., Su, X.L., Lin, R.C. Journal of mass spectrometry : JMS. (2000) [Pubmed]
  11. Podophyllum toxicity: case report and literature review. Moher, L.M., Maurer, S.A. The Journal of family practice. (1979) [Pubmed]
  12. Condyloma. A new epidemic. Moore, G.E., Norton, L.W., Meiselbaugh, D.M. Archives of surgery (Chicago, Ill. : 1960) (1978) [Pubmed]
  13. Synthesis of podophyllotoxin congeners as potential DNA topoisomerase II inhibitors. Kamal, A., Atchison, K., Daneshtalab, M., Micetich, R.G. Anticancer Drug Des. (1995) [Pubmed]
  14. The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans. Puri, S.C., Nazir, A., Chawla, R., Arora, R., Riyaz-Ul-Hasan, S., Amna, T., Ahmed, B., Verma, V., Singh, S., Sagar, R., Sharma, A., Kumar, R., Sharma, R.K., Qazi, G.N. J. Biotechnol. (2006) [Pubmed]
  15. Inflammatory parameters in rheumatoid arthritis during and after administration of an anti-mitotic agent (Podophyllum lignan derivatives). Berglund, K., Johansson, B.G., Laurell, A.B., Sjöholm, A., Sturfelt, G. Scand. J. Rheumatol. (1978) [Pubmed]
  16. Enhancement of radiation-induced apoptosis by Podophyllum hexandrum. Prem Kumar, I., Rana, S.V., Samanta, N., Goel, H.C. J. Pharm. Pharmacol. (2003) [Pubmed]
  17. Reduction in the number of infective Trichinella spiralis larvae in mice by use of homeopathic drugs. Sukul, N.C., Ghosh, S., Sinhababu, S.P. Forschende Komplementärmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine. (2005) [Pubmed]
  18. Podophyllum derivatives (CPH 82) compared with placebo in the treatment of rheumatoid arthritis. Larsen, A., Petersson, I., Svensson, B. Br. J. Rheumatol. (1989) [Pubmed]
  19. Immunoassay of podophyllotoxin. Yoo, K., Porter, J.R. J. Nat. Prod. (1993) [Pubmed]
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