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Gene Review

Rapop1  -  radiation-induced apoptosis 1

Mus musculus

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Disease relevance of Rapop1


High impact information on Rapop1


Chemical compound and disease context of Rapop1


Biological context of Rapop1


Anatomical context of Rapop1


Associations of Rapop1 with chemical compounds


Regulatory relationships of Rapop1


Other interactions of Rapop1


Analytical, diagnostic and therapeutic context of Rapop1


  1. Protease inhibitors restore radiation-induced apoptosis to Bcl-2-expressing lymphoma cells. Kurland, J.F., Meyn, R.E. Int. J. Cancer (2001) [Pubmed]
  2. Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies. Martinive, P., Defresne, F., Bouzin, C., Saliez, J., Lair, F., Gr??goire, V., Michiels, C., Dessy, C., Feron, O. Cancer Res. (2006) [Pubmed]
  3. Radiation-induced apoptosis in human sarcoma and glioma cell lines. Stapper, N.J., Stuschke, M., Sak, A., Stüben, G. Int. J. Cancer (1995) [Pubmed]
  4. Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. Russo, S.M., Tepper, J.E., Baldwin, A.S., Liu, R., Adams, J., Elliott, P., Cusack, J.C. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  5. Radiation-induced apoptosis in F9 teratocarcinoma cells. Langley, R.E., Palayoor, S.T., Coleman, C.N., Bump, E.A. Int. J. Radiat. Biol. (1994) [Pubmed]
  6. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Santana, P., Peña, L.A., Haimovitz-Friedman, A., Martin, S., Green, D., McLoughlin, M., Cordon-Cardo, C., Schuchman, E.H., Fuks, Z., Kolesnick, R. Cell (1996) [Pubmed]
  7. p53 is required for radiation-induced apoptosis in mouse thymocytes. Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., Jacks, T. Nature (1993) [Pubmed]
  8. Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2. Mukhopadhyay, D., Houchen, C.W., Kennedy, S., Dieckgraefe, B.K., Anant, S. Mol. Cell (2003) [Pubmed]
  9. Protection from anti-TCR/CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1/stem cell antigen-2. Noda, S., Kosugi, A., Saitoh, S., Narumiya, S., Hamaoka, T. J. Exp. Med. (1996) [Pubmed]
  10. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. Tessner, T.G., Muhale, F., Riehl, T.E., Anant, S., Stenson, W.F. J. Clin. Invest. (2004) [Pubmed]
  11. Isolation and characterization of apoptosis-resistant mutants from a radiosensitive mouse lymphoma cell line. Kawai, H., Kitamura, Y., Nikaido, O., Tatsuka, M., Hama-Inaba, H., Muto, M., Ohyama, H., Suzuki, F. Radiat. Res. (1998) [Pubmed]
  12. Effect of a hypoxic cell sensitizer doranidazole on the radiation-induced apoptosis of mouse L5178Y lymphoma cells. Aoki, M., Furusawa, Y., Shibamoto, Y., Kobayashi, A., Tsujitani, M. J. Radiat. Res. (2002) [Pubmed]
  13. Enhancement of radiation-induced regrowth delay by gemcitabine in a human tumor xenograft model. Joschko, M.A., Webster, L.K., Groves, J., Yuen, K., Palatsides, M., Ball, D.L., Millward, M.J. Radiation oncology investigations. (1997) [Pubmed]
  14. Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis. Mori, N., Matsumoto, Y., Okumoto, M., Suzuki, N., Yamate, J. Oncogene (2001) [Pubmed]
  15. Apoptosis susceptibility genes on mouse chromosome 9 (Rapop2) and chromosome 3 (Rapop3). Mori, N., Okumoto, M., Hart, A.A., Demant, P. Genomics (1995) [Pubmed]
  16. Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo. Maggiorella, L., Deutsch, E., Frascogna, V., Chavaudra, N., Jeanson, L., Milliat, F., Eschwege, F., Bourhis, J. Cancer Res. (2003) [Pubmed]
  17. Genetics of susceptibility to radiation-induced apoptosis in colon: two loci on chromosomes 9 and 16. Mori, N., van Wezel, T., van der Valk, M., Yamate, J., Sakuma, S., Okumoto, M., Demant, P. Mamm. Genome (1998) [Pubmed]
  18. Radiation-induced apoptosis in peritoneal resident macrophages of C3H mice. Kubota, Y., Takahashi, S., Sato, H., Suetomi, K., Aizawa, S. J. Radiat. Res. (2004) [Pubmed]
  19. Loss of matrix adhesion triggers rapid transformation-selective apoptosis in fibroblasts. McGill, G., Shimamura, A., Bates, R.C., Savage, R.E., Fisher, D.E. J. Cell Biol. (1997) [Pubmed]
  20. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Chong, M.J., Murray, M.R., Gosink, E.C., Russell, H.R., Srinivasan, A., Kapsetaki, M., Korsmeyer, S.J., McKinnon, P.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  21. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Egan, L.J., Eckmann, L., Greten, F.R., Chae, S., Li, Z.W., Myhre, G.M., Robine, S., Karin, M., Kagnoff, M.F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  22. Modulation of radiation-induced apoptosis by thiolamines. Warters, R.L., Roberts, J.C., Wilmore, B.H., Kelley, L.L. Int. J. Radiat. Biol. (1997) [Pubmed]
  23. Induction of heat shock protein 70 protects thymocytes against radiation-induced apoptosis. Gordon, S.A., Hoffman, R.A., Simmons, R.L., Ford, H.R. Archives of surgery (Chicago, Ill. : 1960) (1997) [Pubmed]
  24. Comparison of effects of doxorubicin and radiation on p53-dependent apoptosis in vivo. Hayakawa, K., Hasegawa, M., Kawashima, M., Nakamura, Y., Matsuura, M., Toda, H., Hayakawa, K., Mitsuhashi, N., Niibe, H. Oncol. Rep. (2000) [Pubmed]
  25. Loss of ceramide production confers resistance to radiation-induced apoptosis. Chmura, S.J., Nodzenski, E., Beckett, M.A., Kufe, D.W., Quintans, J., Weichselbaum, R.R. Cancer Res. (1997) [Pubmed]
  26. Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Huang, S.M., Li, J., Armstrong, E.A., Harari, P.M. Cancer Res. (2002) [Pubmed]
  27. Protein kinase Cdelta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest. Lee, Y.J., Soh, J.W., Dean, N.M., Cho, C.K., Kim, T.H., Lee, S.J., Lee, Y.S. Cell Growth Differ. (2002) [Pubmed]
  28. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Mizuki, M., Fenski, R., Halfter, H., Matsumura, I., Schmidt, R., Müller, C., Grüning, W., Kratz-Albers, K., Serve, S., Steur, C., Büchner, T., Kienast, J., Kanakura, Y., Berdel, W.E., Serve, H. Blood (2000) [Pubmed]
  29. Inhibition of nuclear factor-kappaB cascade potentiates the effect of a combination treatment of anaplastic thyroid cancer cells. Starenki, D., Namba, H., Saenko, V., Ohtsuru, A., Yamashita, S. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  30. Bcl-XL antisense oligonucleotides coupled with antennapedia enhances radiation-induced apoptosis in pancreatic cancer. Masui, T., Hosotani, R., Ito, D., Kami, K., Koizumi, M., Mori, T., Toyoda, E., Nakajima, S., Miyamoto, Y., Fujimoto, K., Doi, R. Surgery (2006) [Pubmed]
  31. Modulations of glucocorticoid-induced apoptosis linked to the p53 deletion and to the apoptosis susceptibility gene Rapop1 (Radiation-induced apoptosis 1). Mori, N., Yamate, J., Stassen, A.P., Oka, S., Okumoto, M., Tsubura, A., Akamatsu, T., Sakuma, S., Demant, P. Oncogene (1999) [Pubmed]
  32. DR5 knockout mice are compromised in radiation-induced apoptosis. Finnberg, N., Gruber, J.J., Fei, P., Rudolph, D., Bric, A., Kim, S.H., Burns, T.F., Ajuha, H., Page, R., Wu, G.S., Chen, Y., McKenna, W.G., Bernhard, E., Lowe, S., Mak, T., El-Deiry, W.S. Mol. Cell. Biol. (2005) [Pubmed]
  33. DNA damage-induced apoptosis and Ice gene induction in mitogenically activated T lymphocytes require IRF-1. Tamura, T., Ishihara, M., Lamphier, M.S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T.W., Taki, S., Taniguchi, T. Leukemia (1997) [Pubmed]
  34. Genetic dissection of susceptibility to radiation-induced apoptosis of thymocytes and mapping of Rapop1, a novel susceptibility gene. Mori, N., Okumoto, M., van der Valk, M.A., Imai, S., Haga, S., Esaki, K., Hart, A.A., Demant, P. Genomics (1995) [Pubmed]
  35. Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy. Rupnow, B.A., Murtha, A.D., Alarcon, R.M., Giaccia, A.J., Knox, S.J. Cancer Res. (1998) [Pubmed]
  36. Cell cycle alterations, apoptosis, and response to low-dose-rate radioimmunotherapy in lymphoma cells. Macklis, R.M., Beresford, B.A., Palayoor, S., Sweeney, S., Humm, J.L. Int. J. Radiat. Oncol. Biol. Phys. (1993) [Pubmed]
  37. Correlation between single nucleotide polymorphisms and jejunal crypt cell apoptosis after whole body irradiation. Iwata, M., Iwakawa, M., Noda, S., Ohta, T., Minfu, Y., Kimura, T., Shibuya, H., Imai, T. Int. J. Radiat. Biol. (2007) [Pubmed]
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