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MeSH Review:

Miller Fisher Syndrome

Chida, K. et al., Goffette, S. et al., Yoshitomi, T. et al., Shin, J.E. et al., Odaka, M. et al., et al.

Chiba, Sugiyama, Yonekura, Tanaka, Matsumoto, Fujii, Yokota, Hirayama, Hughes, Hadden, Gregson, Smith, Tanaka, Yuki, Hirata,

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Disease relevance of Miller Fisher Syndrome

Circulating IgG antibodies to carbohydrate determinants on GQ1b ganglioside are found in the acute phase sera of patients with Miller Fisher syndrome, a variant of Guillain-Barré syndrome [1].
The Fisher syndrome of ophthalmoplegia, ataxia and areflexia is the most striking of several related conditions [2].
The IAP using a tryptophan column has a beneficial effect on Miller Fisher syndrome but may not inhibit the development of facial palsy [3].
Two patients are reported on with Miller Fisher syndrome, who developed bilateral facial palsy during IAP using a tryptophan column, while ophthalmoplegia, ataxia, and, areflexia were improving [3].
We investigated the immunological features of ADEM using flow cytometry to examine interferon gamma (IFN-gamma)-and interleukin 4 (IL-4)-producing peripheral blood CD3+T cells from four patients with ADEM, three other neurological disorders (Fisher syndrome, epilepsy and aseptic meningitis) and 10 healthy children [4].

High impact information on Miller Fisher Syndrome

OBJECTIVE: To compare the clinical course of an unusual case of Miller-Fisher syndrome in systemic lupus erythematosus with therapeutic interventions, in particular with plasma exchanges [5].
Information on patients' antecedent illnesses, initial symptoms, neurological signs, and CSF findings was reviewed in those with ataxic GBS or Fisher syndrome (FS) with anti-GM1b or anti-GalNAc-GD1a IgG antibodies [6].
Myelin basic protein in Fisher syndrome [7].
This triad characterizes Miller Fisher syndrome, a clinical variant of Guillain-Barré syndrome that occurs rarely among children [8].
A 65-year-old woman with Fisher syndrome was investigated by gadolinium-enhanced 3-D MRI [9].

Chemical compound and disease context of Miller Fisher Syndrome

Lipo-oligosaccharide (LOSa) was obtained by phenol-water extraction of bacterial cells of an isolate PG 836, identified as Campylobacter jejuni serotype O:10, from a patient who subsequently developed the Miller-Fisher syndrome (MFS) [10].
We describe the first case of Miller Fisher syndrome (opthalmoplegia, ataxia, and areflexia) associated with lactic acidosis as an adverse effect of receipt of an antiretroviral regimen containing stavudine [11].

Gene context of Miller Fisher Syndrome

In some patients with Guillain-Barré syndrome or Miller Fisher syndrome, IAP increased during the acute phase [12].
The authors examined antibodies against native vacuolating cytotoxin (VacA) of Helicobacter pylori in CSF from 12 patients with Miller-Fisher syndrome (MFS) [13].

Analytical, diagnostic and therapeutic context of Miller Fisher Syndrome

Anti-GQ1b antibodies were assayed by an enzyme-linked immunosorbent assay in sera from patients with non-neurological disorders (N = 20), and with various neurological disorders (N = 59), including nine cases of Miller Fisher syndrome, 16 cases of Guillain-Barré syndrome and one case of acute post-infectious ophthalmoparesis [14].

References

Immunoglobulin subclass distribution and binding characteristics of anti-GQ1b antibodies in Miller Fisher syndrome. Willison, H.J., Veitch, J. J. Neuroimmunol. (1994) [Pubmed]
Pathogenesis of Guillain-Barré syndrome. Hughes, R.A., Hadden, R.D., Gregson, N.A., Smith, K.J. J. Neuroimmunol. (1999) [Pubmed]
Development of facial palsy during immunoadsorption plasmapheresis in Miller Fisher syndrome: a clinical report of two cases. Chida, K., Takase, S., Itoyama, Y. J. Neurol. Neurosurg. Psychiatr. (1998) [Pubmed]
Increased peripheral blood interferon gamma-producing T cells in acute disseminated encephalomyelitis. Yoshitomi, T., Matsubara, T., Nishikawa, M., Katayama, K., Ichiyama, T., Hayashi, T., Furukawa, S. J. Neuroimmunol. (2000) [Pubmed]
Lupus erythematosus and Miller-Fisher syndrome. Bingisser, R., Speich, R., Fontana, A., Gmür, J., Vogel, B., Landis, T. Arch. Neurol. (1994) [Pubmed]
Ataxic Guillain-Barré syndrome associated with anti-GM1b and anti-GalNAc-GD1a antibodies. Odaka, M., Yuki, N., Tatsumoto, M., Tateno, M., Hirata, K. J. Neurol. (2004) [Pubmed]
Myelin basic protein in Fisher syndrome. Matias-Guiu, J., Ruibal, A., Alvarez, J., Fraile, M., Martinez-Vazquez, J.M. J. Neurol. (1985) [Pubmed]
Benign intracranial hypertension: atypical presentation of Miller Fisher syndrome? Mewasingh, L.D., Sékhara, T., Dachy, B., Djeunang, M.C., Dan, B. Pediatric neurology. (2002) [Pubmed]
Trochlear nerve enhancement on three-dimensional magnetic resonance imaging in Fisher syndrome. Tanaka, H., Yuki, N., Hirata, K. Am. J. Ophthalmol. (1998) [Pubmed]
Lipo-oligosaccharides of Campylobacter jejuni serotype O:10. Structures of core oligosaccharide regions from a bacterial isolate from a patient with the Miller-Fisher syndrome and from the serotype reference strain. Shin, J.E., Ackloo, S., Mainkar, A.S., Monteiro, M.A., Pang, H., Penner, J.L., Aspinall, G.O. Carbohydr. Res. (1997) [Pubmed]
Miller Fisher variant of Guillain-Barré syndrome associated with lactic acidosis and stavudine therapy. Shah, S.S., Rodriguez, T., McGowan, J.P. Clin. Infect. Dis. (2003) [Pubmed]
Significant increase in immunosuppressive acidic protein (IAP) in serum of patients with multiple sclerosis and other inflammatory neurological disorders. Tsukamoto, T., Seki, H., Takase, S., Sekizawa, T., Nakamura, S. J. Neurol. Sci. (1986) [Pubmed]
An antibody to VacA of Helicobacter pylori in the CSF of patients with Miller-Fisher syndrome. Chiba, S., Sugiyama, T., Yonekura, K., Tanaka, S., Matsumoto, H., Fujii, N., Yokota, S., Hirayama, T. Neurology (2004) [Pubmed]
Clinical relevance of the determination of anti-GQ1b antibodies in Miller Fisher and Guillain-Barré syndromes. Goffette, S., Jeanjean, A., Pierret, F., Peeters, A., Sindic, C.J. Acta neurologica Belgica. (1998) [Pubmed]

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