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Gene Review

recA  -  recombinase A

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of recA

 

High impact information on recA

  • A constitutively expressed, truncated umuDC operon regulates the recA-dependent DNA damage induction of a gene in Acinetobacter baylyi strain ADP1 [6].
  • Analyses of the Brucella spp. genomes and our molecular studies documented the presence of only one recA gene, suggesting a RecA-independent repair process [7].
  • The appearance of Arg(+) mutants on the plates with streptomycin was not significantly altered by recA, rpoS or dps mutations [8].
  • The effect of coating single- and double-stranded DNA with the recombinase A protein of Escherichia coli on transgene integration in mice [9].
  • Using single-stranded DNA, non-coated constructs produced a transgene integration rate of 0.5%, while none of the 1040 zygotes injected with recombinase A-coated constructs produced transgenic pups [9].
 

Biological context of recA

  • Interestingly, deletion did not occur in A. tumefaciens strain AGL1 with a recA mutation in C58 chromosome, implying a clear role for recombination in deletion [10].
  • A 100-fold reduction in the recombination rate was observed in a recA mutant strain even though crossing-over was still efficient [11].
  • In Escherichia coli the LexA protein acts as a recA repressor and is able, in response to DNA damage, of RecA-promoted self-cleavage, thus allowing recA transcription [4].
  • The analysis of deletion mutants and of translational gene fusions showed that a DNA region of 83 base pairs, containg the recA promoter and the transcriptional start site, is sufficient to ensure normal expression of the gene [4].
  • A deletion of the ykoV gene encoding the B. subtilis Ku protein in a sbcC mutant strain did not resulted in an increase in sensitivity towards MMC and gamma irradiation, but exacerbated the phenotype of a recN or a recA mutant strain [12].

References

  1. Cleavage of the Escherichia coli lexA protein by the recA protease. Little, J.W., Edmiston, S.H., Pacelli, L.Z., Mount, D.W. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  2. New rapid and simple methods for detection of bacteria and determination of their antibiotic susceptibility by using phage mutants. Ulitzur, N., Ulitzur, S. Appl. Environ. Microbiol. (2006) [Pubmed]
  3. Isolation of bacteriocinogenic Lactobacillus plantarum strains from ben saalga, a traditional fermented gruel from Burkina Faso. Omar, N.B., Abriouel, H., Lucas, R., Mart??nez-Ca??amero, M., Guyot, J.P., G??lvez, A. Int. J. Food Microbiol. (2006) [Pubmed]
  4. Transcriptional analysis of the recA gene of Streptococcus thermophilus. Giliberti, G., Baccigalupi, L., Cordone, A., Ricca, E., De Felice, M. Microb. Cell Fact. (2006) [Pubmed]
  5. RecA-independent pathways of lambdoid prophage induction in Escherichia coli. Rozanov, D.V., D'Ari, R., Sineoky, S.P. J. Bacteriol. (1998) [Pubmed]
  6. A constitutively expressed, truncated umuDC operon regulates the recA-dependent DNA damage induction of a gene in Acinetobacter baylyi strain ADP1. Hare, J.M., Perkins, S.N., Gregg-Jolly, L.A. Appl. Environ. Microbiol. (2006) [Pubmed]
  7. RecA and RadA proteins of Brucella abortus do not perform overlapping protective DNA repair functions following oxidative burst. Roux, C.M., Booth, N.J., Bellaire, B.H., Gee, J.M., Roop, R.M., Kovach, M.E., Tsolis, R.M., Elzer, P.H., Ennis, D.G. J. Bacteriol. (2006) [Pubmed]
  8. Mistranslation and genetic variability The effect of streptomycin. Nagel, R., Chan, A. Mutat. Res. (2006) [Pubmed]
  9. The effect of coating single- and double-stranded DNA with the recombinase A protein of Escherichia coli on transgene integration in mice. Mason, J.B., Najarian, J.G., Anderson, G.B., Murray, J.D., Maga, E.A. Transgenic Res. (2006) [Pubmed]
  10. Factors contributing to deletion within Mungbean yellow mosaic virus partial dimers in binary vectors used for agroinoculation. Shivaprasad, P.V., Thomas, M., Balamani, V., Biswas, D., Vanitharani, R., Karthikeyan, A.S., Veluthambi, K. J. Virol. Methods (2006) [Pubmed]
  11. Gene reconstitution using high efficiency homologous recombination between a bacteriophage fd and a plasmid. Br??do, A., Mathonet, P., Deschuyteneer, G., Soumillion, P. J. Biotechnol. (2006) [Pubmed]
  12. Bacillus subtilis SbcC protein plays an important role in DNA inter-strand cross-link repair. Mascarenhas, J., Sanchez, H., Tadesse, S., Kidane, D., Krisnamurthy, M., Alonso, J.C., Graumann, P.L. BMC Mol. Biol. (2006) [Pubmed]
 
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