Disease relevance of Diagnostic Errors

• The major diagnostic error is the failure to document hypoglycemia (that is, record plasma glucose levels) at the time the patient is spontaneously symptomatic [1].
• AIMS: The histopathological, immunohistochemical and ultrastructural features of a primary 'mucin-positive' epithelial mesothelioma of the peritoneum are reported to draw attention to a potential cause of diagnostic error [2].
• Guidelines are suggested that permit rapid evaluation, while limiting diagnostic errors, when using 67Ga citrate radionuclide imaging and CT in the presence or absence of localizing symptoms and signs [3].
• The demonstrated diagnostic errors do not detract from the value of tetracycline pleurodesis when spontaneous pneumothorax is caused by rupture of only tiny blebs on the surface of an otherwise healthy lung [4].

High impact information on Diagnostic Errors

• These secondary autonomic effects of epilepsy may lead to diagnostic errors if their cerebral origins are not suspected [5].
• However, such a diagnostic error seems to have little effect, at least in the first year of therapy, on the effectiveness of GH treatment [6].
• DNA-based detection of the MH status in 376 MH-susceptible heterozygous (N/n) and homozygous (n/n) pigs was shown to be accurate, eliminating the 5% diagnostic error that is associated with the halothane challenge test and flanking marker haplotyping procedures in current diagnostic use [7].
• The combined reduction of DMD/BMD diagnostic error rate and familial recurrence could explain these results, providing the bases for a consistent redefinition of dystrophinopathy carrier frequency in the area considered [8].
• The perceived clinical value of NMR measurements on biopsy specimens. Part I. Interval estimates of diagnostic error rates and a note on an effect of the law of small numbers [9].

Biological context of Diagnostic Errors

• DNA diagnostic errors can be caused by the presence of the highly homologous 21-hydroxylase pseudogene, CYP21P, adjacent to the functional gene, CYP21 [10].

Associations of Diagnostic Errors with chemical compounds

• The typical thymic appearance on CT and the chronologic relation to declining cortisol levels should prevent such diagnostic errors [11].
• The occiput to C2 region was the most common site of diagnostic error [12].
• Plasma noradrenaline and adrenaline measurements may be superior to measurements of urinary catecholamine metabolites, but strict attention to the details of sample collection, handling and storage, the many sources of possible biological variation and the effects of drugs is critical if diagnostic error is to be avoided [13].
• Some laboratory tests used in anemia, particularly measurement of serum vitamin B12 and folate levels, may present problems in interpretation, which must be recognized if diagnostic errors are to be avoided [14].

Gene context of Diagnostic Errors

• With the widespread availability of immunoperoxidase staining for LCA, this diagnostic error should be minimized [15].
• The concordance limits indicate that Clamp and Min-Mod are not equivalent, which could result in diagnostic errors if the accepted cut-off point is used for both methods [16].
• Latent class modeling approaches for assessing diagnostic error without a gold standard: with applications to p53 immunohistochemical assays in bladder tumors [17].
• Iatrogenic harm caused by diagnostic errors in fibrodysplasia ossificans progressiva [18].
• We conclude that laboratories are generally proficient in their testing for VWD and that diagnostic error rates are substantially reduced when test panels are more comprehensive and include the VWF:CB [19].

References