Disease relevance of Pneumothorax

• SETTING: The MICU in a 970-bed teaching hospital in Paris, France. PATIENTS: A total of 120 consecutive AIDS patients with acute respiratory failure (50%), central nervous system dysfunction (22.5%), pneumothorax (12.5%), shock (10.8%), or miscellaneous conditions (4.2%) [1].
• Complications were minimal, two instances of pneumothorax (6.3 percent) and two of hemoptysis (6.3 percent) [2].
• CONCLUSIONS: Although associated with intense immediate chest pain, additional minocycline pleurodesis is a safe and convenient procedure that can reduce the rate of ipsilateral recurrence after thoracoscopic treatment for primary spontaneous pneumothorax [3].
• The univariate analysis identified seven factors predictive of 90-d mortality: Pa(O(2)) on room air < 60 mm Hg, lactate dehydrogenase > 1,000 IU, albuminemia < 30 g/L, BAL neutrophilia > 10%, nosocomial infection, pneumothorax, and a need for mechanical ventilation [4].
• PLS also reduces the incidence of air leak events such as pulmonary interstitial emphysema and pneumothorax [5].

Psychiatry related information on Pneumothorax

• Pneumomediastinum, pneumothorax, and subcutaneous emphysema after alternate cocaine inhalation and marijuana smoking [6].

High impact information on Pneumothorax

• This prospective, multicenter, randomized, "unblinded," controlled clinical trial was designed to determine if the intrapleural instillation of 1500 mg of tetracycline hydrochloride would be effective in diminishing the ipsilateral rate of recurrence for spontaneous pneumothorax [7].
• Lung cancer and pneumothorax [8].
• Pneumothorax in pentamidine-treated haemophiliacs [9].
• A 4-bp deletion in the Birt-Hogg-Dubé gene (FLCN) causes dominantly inherited spontaneous pneumothorax [10].
• After a mean follow-up of 29 mo (12-47 mo), recurrent ipsilateral pneumothorax was noted in two patients in the minocycline group and eight patients in the observation group (p = 0.044 by the Kaplan-Meier method and log-rank test) [3].

Chemical compound and disease context of Pneumothorax

• Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults [11].
• Role of small calibre chest tube drainage for iatrogenic pneumothorax [12].
• CONCLUSIONS: Due to its high solubility the expectant management of incidental CO2 pneumothorax, pneumopericardium and pneumomediastinum is recommended initially in the clinically stable patient [13].
• Evaluation for decrease in O2 saturation should include a search for pneumothorax in these patients [14].
• We recommend that quinacrine sclerosis should be considered for management of the first pneumothorax, and parietal pleurectomy if it fails [15].

Biological context of Pneumothorax

• Birt-Hogg-Dubé syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2 [16].
• We identified risk factors for renal tumors and spontaneous pneumothorax in 98 patients affected with the Birt-Hogg-Dubé syndrome, in 13 Birt-Hogg-Dubé haplotype carriers, and in 112 unaffected family members [17].
• In a three generation family with 27 members we examined a relationship could be found between spontaneous pneumothorax and HLA-haplotypes, alpha 1-antitrypsin phenotypes or concentration or lung volumes and ventilatory capacity [18].
• CONCLUSION: The present study indicates that isolated RD will appear without signs of complement activation and that complications like pneumothorax or intracerebral haemorrhages are associated with release of the anaphylatoxins C3a and C5a [19].
• We compared the histology of CF pleura with that of young non-CF adults with "idiopathic" pneumothorax [20].

Anatomical context of Pneumothorax

• It is important for pathologists to be aware of this rare cause of spontaneous pneumothorax because BHD can radiographically simulate other causes of pulmonary cysts and the lung and pleura may be the initial sites of involvement [21].
• We studied the changes in the concentration of adenine nucleotides as markers of injury in the intact rabbit lung after pulmonary artery occlusion in the presence and absence of pneumothorax [22].
• Vocal cord paralysis due to pneumothorax in a patient with COPD [23].
• Idiopathic spontaneous pneumothorax causes a time-related rise in the eosinophil percentage in the pleural space, which correlates with the level of IL-5 [24].
• There appears to be a place for the use of tolazoline in a severely hypoxaemic infant with hyaline membrane disease who is being ventilated and in whom arterial oxygenation cannot be improved by further increase in the inspired oxygen concentration or by alteration of ventilator settings, provided pneumothorax has been excluded [25].

Gene context of Pneumothorax

• Familial spontaneous pneumothorax and FBN1 mutations [26].
• A Japanese patient with tuberous sclerosis (TSC), who manifested with multiple lung cysts and pneumothorax, is described [27].
• In pneumothorax patients LRP levels were not correlated with the amount of pack years smoked [28].
• SARS, pneumothorax, and our response to epidemics [29].
• Therefore operative treatment for both primary and COPD-related spontaneous pneumothorax should be considered if tube treatment is not successful after 1 week and there are no contraindications [30].

Analytical, diagnostic and therapeutic context of Pneumothorax

• Intrapleural tetracycline therapy is indicated for patients with a spontaneous pneumothorax who are hospitalized and are treated with tube thoracostomy [7].
• OBJECTIVES: This study was conducted to determine whether additional minocycline pleurodesis would be effective in diminishing recurrence after video-assisted thoracoscopic surgery treatment of primary spontaneous pneumothorax [3].
• An Audit of medical thoracoscopy and talc poudrage for pneumothorax prevention in advanced COPD [31].
• Carbon dioxide pneumothorax in laparoscopic surgery [32].
• Carbon dioxide pneumothorax during laparoscopic fundoplication [33].

References