The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

AVP  -  arginine vasopressin

Sus scrofa

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AVP

  • Five heart groups (cold) were perfused with AVP, D-ARG, L-ARG, L-NAME, or nothing (control), but after 2 hours they were perfused at low flow for 22 hours at 3.7 degrees C and again for 3 hours at 37.5 degrees C. ADE, butanedione monoxime, and NP were given for cardioprotection before, during, and after hypothermia [1].
  • BACKGROUND: The purpose of the study was to compare initial resuscitation with arginine vasopressin (AVP), phenylephrine (PE), or isotonic crystalloid fluid alone after traumatic brain injury and vasodilatory shock [2].
  • From these data we assume a simultaneous activation of peripheral and central release of AVP with antidiuretic and antipyretic effects by dehydration [3].
  • Measurements were performed at baseline, after E. coli lipopolysaccharide (LPS) administration and at 20 min intervals during incremental AVP infusion (n=8; 0.014, 0.029, 0.057, 0.114 and 0.229 IU kg(-1) h(-1), respectively) or infusion of saline (n =8) [4].
  • In this report, we present electrophysiological evidence that arginine-vasopressin (AVP) is a neurotransmitter in guinea pig inferior mesenteric ganglion (IMG) [5].

Psychiatry related information on AVP


High impact information on AVP


Chemical compound and disease context of AVP


Biological context of AVP

  • Left ventricular pressure and cardiac efficiency improved more in the postcold L-ARG group than in the postcold D-ARG, AVP, and L-NAME groups [1].
  • In addition, when AVP and inulin were injected into the amniotic sac in vivo during the last week of gestation, the AVP to inulin ratio decreased (P less than 0.05) over a 2-h period, indicating a swallowing-independent disappearance of AVP [16].
  • Moreover, slow excitatory postsynaptic potentials (EPSPs) elicited by repetitive nerve stimulation were attenuated in 75% of cells tested in the presence of excess AVP, and occasionally in the presence of the antagonist [5].
  • Coronary vasoconstriction was elicited by perfusing hearts with increasing concentrations of AVP in random order [17].
  • We found that AVP increased coronary vascular resistance more at CCF than at CPP [17].

Anatomical context of AVP

  • In our experimental conditions, in which myocytes were bathed in Ca(2+)-free high-potassium solutions, AVP-induced potentiation was observed without changes in [Ca2+]i measured by fura 2 fluorescence signals (estimated [Ca2+]i, approximately 80 nmol/L) [18].
  • A maximally active concentration of AVP (1 microM) increased adenylate cyclase activity in canine renal plasma membranes to a value 2.7 times that of basal activity [19].
  • Histidine and imidazole but not alanine (the histidine core structure) increase basal, GTP-, forskolin-, and AVP-stimulated adenylate cyclase activity in LLC-PK1 membranes [20].
  • We explored whether overexpression of one of the cAMP-PDE type isozymes, PDE-IV, in [8-Arg]-vasopressin (AVP) sensitive renal epithelial LLC-PK1 cells can prevent the hormone-elicited cAMP increase [21].
  • Tritiated AVP incubated in only amniotic fluid produced M2, with only slight M1 production [16].

Associations of AVP with chemical compounds

  • However, AVP stimulates adenylate cyclase activity in a dose-dependent fashion with an EC50 of 14 nM, whereas OT or dVDAVP has no effect at 100 nM [22].
  • These pharmacological properties are distinct from the previously described V1 and V2 vasopressin receptors and indicate the presence of a new class of AVP receptors [22].
  • Lysine vasopressin and the V1 antagonist [1-deaminopenicillamine, 2-(O-methyl)tyrosine]Arg8-vasopressin compete with high affinity with [3H]AVP binding, whereas the V2 agonist [1-deamino,4-valine]D-Arg8-vasopressin (dVDAVP) is 110 times less potent than AVP [22].
  • In warm groups, L-ARG did not alter basal flow or ADE, ACh, 5-HT, or NP responses, whereas L-NAME and AVP reduced basal flow and the ADE response, abolished ACh and 5-HT responses, and increased the NP response [1].
  • The explants in the group treated with 7.4 X 10(-5) M indomethacin for 60 min before the experiment and throughout the experiment responded to 6.5 X 10(-8) M angiotensin II with a 166 +/- 42% increase in AVP release over control release [23].

Regulatory relationships of AVP


Other interactions of AVP


Analytical, diagnostic and therapeutic context of AVP

  • The effect of prostaglandins (PGs) on arginine vasopressin (AVP) release was investigated using the male guinea pig hypothalamo-neurohypophyseal complex (HNC) in organ culture [23].
  • When fetal plasma, urine, and amniotic fluid were fractionated on HPLC, AVP was identified only in fetal plasma and urine [16].
  • Effluent fractions were monitored for corticotrophin-releasing factor (CRF) bioactivity, using the perfused isolated pituitary cell column bioassay, and radioimmunoassay for CRF-41, AVP, oxytocin, neurophysin, adrenocorticotrophic hormone (ACTH) and luteinizing hormone-releasing hormone (LHRH) [32].
  • In the presence of tetrodotoxin, OFQ/N hyperpolarized 48 of 48 SON magnocellular neurons, 24 of which were subsequently identified by immunocytochemistry as arginine vasopressin positive (AVP+) [33].
  • Production of cAMP could be detected in BIB27 cells even 12 h after treatment with AVP or SCT, whereas cAMP production in LLC-PK1 had returned to basal within 1 and 8 h, respectively [34].


  1. Effects of L-arginine and N omega-nitro-L-arginine methyl ester on cardiac perfusion and function after 1-day cold preservation of isolated hearts. Stowe, D.F., Boban, M., Roerig, D.L., Chang, D., Palmisano, B.W., Bosnjak, Z.J. Circulation (1997) [Pubmed]
  2. Resuscitation with pressors after traumatic brain injury. Feinstein, A.J., Patel, M.B., Sanui, M., Cohn, S.M., Majetschak, M., Proctor, K.G. J. Am. Coll. Surg. (2005) [Pubmed]
  3. Alteration of endotoxin fever and release of arginine vasopressin by dehydration in the guinea pig. Roth, J., Schulze, K., Simon, E., Zeisberger, E. Neuroendocrinology (1992) [Pubmed]
  4. Arginine vasopressin does not alter mucosal tissue oxygen tension and oxygen supply in an acute endotoxemic pig model. Knotzer, H., Maier, S., Dünser, M.W., Hasibeder, W.R., Hausdorfer, H., Brandner, J., Torgersen, C., Ulmer, H., Friesenecker, B., Iannetti, C., Pajk, W. Intensive care medicine. (2006) [Pubmed]
  5. Vasopressin-mediated slow EPSPs in a mammalian sympathetic ganglion. Peters, S., Kreulen, D.L. Brain Res. (1985) [Pubmed]
  6. Lithium induced polyuria and renal vasopressin receptor density. Hensen, J., Haenelt, M., Gross, P. Nephrol. Dial. Transplant. (1996) [Pubmed]
  7. Hormonal regulation of plasminogen activator mRNA production in porcine kidney cells. Nagamine, Y., Sudol, M., Reich, E. Cell (1983) [Pubmed]
  8. Stimulated vasopressin synthesis by a fetal hypothalamic factor. Pearson, D.B., Goodman, R., Sachs, H. Science (1975) [Pubmed]
  9. Vasopressin and epinephrine for cardiac arrest. Wenzel, V., Lindner, K.H. Lancet (2001) [Pubmed]
  10. Mesenteric vasoconstriction in cardiogenic shock in pigs. Reilly, P.M., MacGowan, S., Miyachi, M., Schiller, H.J., Vickers, S., Bulkley, G.B. Gastroenterology (1992) [Pubmed]
  11. Selective vasopressin, angiotensin II, or dual receptor blockade with developing congestive heart failure. Clair, M.J., King, M.K., Goldberg, A.T., Hendrick, J.W., Nisato, R., Gay, D.M., Morrison, A.E., McElmurray, J.H., Krombach, R.S., Bond, B.R., Cazaubon, C., Nisato, D., Spinale, F.G. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  12. Effects of combined administration of vasopressin, epinephrine, and norepinephrine during cardiopulmonary resuscitation in pigs. Prengel, A.W., Linstedt, U., Zenz, M., Wenzel, V. Crit. Care Med. (2005) [Pubmed]
  13. Heterogeneity of the vasoconstrictor effect of vasopressin in septic shock. Malay, M.B., Ashton, J.L., Dahl, K., Savage, E.B., Burchell, S.A., Ashton, R.C., Sciacca, R.R., Oliver, J.A., Landry, D.W. Crit. Care Med. (2004) [Pubmed]
  14. Age-Dependent vasopressinergic modulation of Noc/oFQ-induced impairment of NMDA cerebrovasodilation after brain injury. Armstead, W.M. J. Neurotrauma (2001) [Pubmed]
  15. Low-dose terlipressin during long-term hyperdynamic porcine endotoxemia: effects on hepatosplanchnic perfusion, oxygen exchange, and metabolism. Asfar, P., Hauser, B., Iványi, Z., Ehrmann, U., Kick, J., Albicini, M., Vogt, J., Wachter, U., Brückner, U.B., Radermacher, P., Bracht, H. Crit. Care Med. (2005) [Pubmed]
  16. Vasopressin metabolism in the amniotic sac of the fetal guinea pig. Uyehara, C.F., Claybaugh, J.R. Endocrinology (1988) [Pubmed]
  17. Differential effects of arginine vasopressin on isolated guinea pig heart function during perfusion at constant flow and constant pressure. Graf, B.M., Fischer, B., Martin, E., Bosnjak, Z.J., Stowe, D.F. J. Cardiovasc. Pharmacol. (1997) [Pubmed]
  18. Arginine vasopressin-induced potentiation of unitary L-type Ca2+ channel current in guinea pig ventricular myocytes. Zhang, S., Hirano, Y., Hiraoka, M. Circ. Res. (1995) [Pubmed]
  19. The synthesis and biological activity of four novel fluorescent vasopressin analogs. Lutz, W.H., Londowski, J.M., Kumar, R. J. Biol. Chem. (1990) [Pubmed]
  20. Histidine regulation of cyclic AMP metabolism in cultured renal epithelial LLC-PK1 cells. Dixon, B.S., Breckon, R., Kaehny, M.M., Dillingham, M.A., Anderson, R.J. J. Biol. Chem. (1990) [Pubmed]
  21. ADH resistance of LLC-pk1 cells caused by overexpression of cAMP-phosphodiesterase type-IV. Yamaki, M., McIntyre, S., Murphy, J.M., Swinnen, J.V., Conti, M., Dousa, T.P. Kidney Int. (1993) [Pubmed]
  22. Identification and characterization of a vasopressin isoreceptor in porcine seminal vesicles. Maggi, M., Kassis, S., Malozowski, S., Guardabasso, V., Rodbard, D. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  23. The effect of prostaglandins on the release of arginine vasopressin from the guinea pig hypothalamo-neurohypophyseal complex in organ culture. Ishikawa, S., Saito, T., Yoshida, S. Endocrinology (1981) [Pubmed]
  24. Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells. Ko, S.B., Naruse, S., Kitagawa, M., Ishiguro, H., Murakami, M., Hayakawa, T. Am. J. Physiol. (1999) [Pubmed]
  25. Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells. Katsura, T., Verbavatz, J.M., Farinas, J., Ma, T., Ausiello, D.A., Verkman, A.S., Brown, D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  26. Is protein kinase C alpha (PKC alpha) involved in vasopressin-induced effects on LLC-PK1 pig kidney cells? Dibas, A., Mia, A.J., Yorio, T. Biochem. Mol. Biol. Int. (1996) [Pubmed]
  27. Central and peripheral doses of cholecystokinin that inhibit feeding in pigs also stimulate vasopressin and cortisol release. Parrott, R.F., Ebenezer, I.S., Baldwin, B.A., Forsling, M.L. Exp. Physiol. (1991) [Pubmed]
  28. Growth, enzyme activity, sugar transport, and hormone supplement responses in cells cloned from a pig kidney cell line LLC-PK1. Miller, J.H., Heath, L.N. J. Cell. Physiol. (1989) [Pubmed]
  29. Endothelin synthesis by porcine inner medullary collecting duct cells. Effects of hormonal and osmotic stimuli. Migas, I., Bäcker, A., Meyer-Lehnert, H., Kramer, H.J. Am. J. Hypertens. (1995) [Pubmed]
  30. Hormone-mediated Ca2+ transients in isolated renal cortical thick ascending limb cells. Dai, L.J., Quamme, G.A. Pflugers Arch. (1994) [Pubmed]
  31. Inhibition by [Arg8]-vasopressin of long term potentiation in guinea pig hippocampal slice. Sakurai, E., Maeda, T., Kaneko, S., Akaike, A., Satoh, M. Jpn. J. Pharmacol. (1998) [Pubmed]
  32. Comparative chromatography of hypothalamic corticotrophin-releasing factors. Gillies, G.E., Puri, A., Linton, E.A., Lowry, P.J. Neuroendocrinology (1984) [Pubmed]
  33. Activation of an inwardly rectifying K+ conductance by orphanin-FQ/nociceptin in vasopressin-containing neurons. Slugg, R.M., Rønnekleiv, O.K., Grandy, D.K., Kelly, M.J. Neuroendocrinology (1999) [Pubmed]
  34. A novel LLC-PK1 renal epithelial cell mutant impaired in in vivo down-regulation of cAMP-mediated hormonal response. Jans, D.A., Resink, T.J., Hemmings, B.A. Arch. Biochem. Biophys. (1991) [Pubmed]
WikiGenes - Universities