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Chemical Compound Review

Bretylol     (2-bromophenyl)methyl-ethyl- dimethyl...

Synonyms: Bretylan, Bretylate, Darenthin, Ornid, Lopac-B-8406, ...
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Disease relevance of Bretylium tosylate


High impact information on Bretylium tosylate


Chemical compound and disease context of Bretylium tosylate


Biological context of Bretylium tosylate


Anatomical context of Bretylium tosylate


Associations of Bretylium tosylate with other chemical compounds


Gene context of Bretylium tosylate


Analytical, diagnostic and therapeutic context of Bretylium tosylate


  1. Bretylium tosylate: a newly available antiarrhythmic drug for ventricular arrhythmias. Heissenbuttel, R.H., Bigger, J.T. Ann. Intern. Med. (1979) [Pubmed]
  2. Bretylium tosylate and ventricular fibrillation in hypothermia. Kochar, G., Kahn, S.E., Kotler, M.N. Ann. Intern. Med. (1986) [Pubmed]
  3. Experience with bretylium tosylate by a hospital cardiac arrest team. Holder, D.A., Sniderman, A.D., Fraser, G., Fallen, E.L. Circulation (1977) [Pubmed]
  4. Prevention of chronic canine ventricular tachyarrhythmias with bretylium tosylate. Patterson, E., Gibson, J.K. Circulation (1981) [Pubmed]
  5. Central nervous system actions of calcitonin gene-related peptide on gastric acid secretion in the rat. Lenz, H.J., Mortrud, M.T., Rivier, J.E., Brown, M.R. Gastroenterology (1985) [Pubmed]
  6. Persistence of sympathetic-mediated forearm vasoconstriction after alpha-blockade in hypertensive patients. Taddei, S., Salvetti, A., Pedrinelli, R. Circulation (1989) [Pubmed]
  7. A method for quantitating antifibrillatory effects of drugs after coronary reperfusion in dogs: improved outcome with bretylium. Wenger, T.L., Lederman, S., Starmer, C.F., Brown, T., Strauss, H.C. Circulation (1984) [Pubmed]
  8. Bretylium Tosylate; adverse effects in acute myocardial infarction. Luomanmaäki, K., Heikkilä, J., Härtel, G. Arch. Intern. Med. (1975) [Pubmed]
  9. Nomogram for bretylium dosing in renal impairment. Adir, J., Narang, P.K., Josselson, J. Therapeutic drug monitoring. (1985) [Pubmed]
  10. Quinidine syncope. A report of successful treatment with bretylium tosylate. VanderArk, C.R., Reynolds, E.W., Kahn, D.R., Tullett, G. J. Thorac. Cardiovasc. Surg. (1976) [Pubmed]
  11. Antiarrhythmic and electrophysiologic actions of bethanidine sulfate in primary ventricular fibrillation or life-threatening ventricular tachycardia. Benditt, D.G., Benson, D.W., Dunnigan, A., Kriett, J.M., Pritzker, M.R., Bacaner, M.B. Am. J. Cardiol. (1984) [Pubmed]
  12. Treatment of refractory ventricular arrhythmias. High dose parenteral and oral bretylium tosylate. Noneman, J.W., Batenhorst, R.L., Jones, M.R., Garrett, E.R., Foster, T.S. Chest (1982) [Pubmed]
  13. Membrane action and catecholamine release action of bretylium tosylate in normoxic and hypoxic canine Purkinje fibers. Nishimura, M., Watanabe, Y. J. Am. Coll. Cardiol. (1983) [Pubmed]
  14. Effects of bretylium tosylate on voltage-gated potassium channels in human T lymphocytes. Gáspár, R., Panyi, G., Ypey, D.L., Krasznai, Z., Vereb, G., Pieri, C., Damjanovich, S. Mol. Pharmacol. (1994) [Pubmed]
  15. The class III antiarrhythmic drug amiodarone directly activates pertussis toxin-sensitive G proteins. Hagelüken, A., Nürnberg, B., Harhammer, R., Grünbaum, L., Schunack, W., Seifert, R. Mol. Pharmacol. (1995) [Pubmed]
  16. Atrial receptors and heart rate: the efferent pathway. Kappagoda, C.T., Linden, R.J., Scott, E.M., Snow, H.M. J. Physiol. (Lond.) (1975) [Pubmed]
  17. Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Stephens, D.P., Aoki, K., Kosiba, W.A., Johnson, J.M. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  18. Muscarinic receptor heterogeneity revealed by interaction with bretylium tosylate. Different ligand-receptor conformations versus different receptor subclasses. Schreiber, G., Sokolovsky, M. Mol. Pharmacol. (1985) [Pubmed]
  19. Bretylium kinetics in renal insufficiency. Josselson, J., Narang, P.K., Adir, J., Yacobi, A., Sadler, J.H. Clin. Pharmacol. Ther. (1983) [Pubmed]
  20. Altered neurotransmitter control of reflex vasoconstriction in aged human skin. Thompson, C.S., Kenney, W.L. J. Physiol. (Lond.) (2004) [Pubmed]
  21. The involvement of nitric oxide in the cutaneous vasoconstrictor response to local cooling in humans. Hodges, G.J., Zhao, K., Kosiba, W.A., Johnson, J.M. J. Physiol. (Lond.) (2006) [Pubmed]
  22. Nitric oxide and noradrenaline contribute to the temperature threshold of the axon reflex response to gradual local heating in human skin. Houghton, B.L., Meendering, J.R., Wong, B.J., Minson, C.T. J. Physiol. (Lond.) (2006) [Pubmed]
  23. Serotonergic regulation of the release of renin is not mediated by the autonomic nervous system but involves beta adrenoceptors. Van de Kar, L.D., Richardson-Morton, K.D. Neuropharmacology (1986) [Pubmed]
  24. Baroreceptor control of the cutaneous active vasodilator system. Crandall, C.G., Johnson, J.M., Kosiba, W.A., Kellogg, D.L. J. Appl. Physiol. (1996) [Pubmed]
  25. Competitive inhibition of acetylcholinesterase by bretylium: possible mechanism for its induction of norepinephrine release. Schreiber, G., Sokolovsky, M. J. Cardiovasc. Pharmacol. (1985) [Pubmed]
  26. A sodium channel opener inhibits stimulation of human peripheral blood mononuclear cells. Pieri, C., Recchioni, R., Moroni, F., Marcheselli, F., Falasca, M., Krasznai, Z., Gáspár, R., Mátyus, L., Damjanovich, S. Mol. Immunol. (1992) [Pubmed]
  27. Exogenous melatonin delays gastric emptying rate in rats: role of CCK2 and 5-HT3 receptors. Kasimay, O., Cakir, B., Devseren, E., Yegen, B.C. J. Physiol. Pharmacol. (2005) [Pubmed]
  28. Oral and intravenous bretylium disposition. Anderson, J.L., Patterson, E., Wagner, J.G., Stewart, J.R., Behm, H.L., Lucchesi, B.R. Clin. Pharmacol. Ther. (1980) [Pubmed]
  29. Effects of bretylium and lidocaine on ventricular fibrillation in the isolated rabbit heart. Aravindakshan, V., Gettes, L.S. Cardiovasc. Res. (1975) [Pubmed]
  30. Management of ventricular dysrhythmias in the prehospital and emergency department setting. Mayer, N.M. Am. J. Cardiol. (1984) [Pubmed]
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