Disease relevance of Sarcocystidae

• Sera from non-infected cattle and cattle infected with Anaplasma, Babesia, Theileria and Sarcocystis were tested for antibodies to Besnoitia in ELISA and immunofluorescence tests (IFT) with Besnoitia besnoiti of blue wildebeest origin as antigen [1].

High impact information on Sarcocystidae

• Cellular immunity to toxoplasma and besnoitia in hamsters: specificity and the effects of cortisol [2].
• Here we explored dexamethasone treatment as a means to render outbred mice susceptible to Besnoitia darlingi infection and demonstrated that this approach allows viable parasites to be subsequently isolated from these mice and maintained in tissue culture [3].
• Determination of the activity of sulfadiazine against Besnoitia darlingi tachyzoites in cultured cells [4].
• Indirect fluorescence and enzyme-linked immunosorbent assays carried out with sera from mice chronically infected with Toxoplasma gondii and Besnoitia sp. showed, as expected, a stronger reaction against homologous than heterologous antigens [5].
• Using a closely related parasite (Besnoitia jellisoni) as antigen, and homologous or heterologous immune sera, it was demonstrated by light and electron microscopy that CIA is a very reliable and specific test [6].

Anatomical context of Sarcocystidae

• Multinucleated cysts near the luminal surface of the thoracic aortas of diseased knots (Calidris canutus) were similar to besnoitia cysts [7].

Associations of Sarcocystidae with chemical compounds

• Sulfadiazine may have promise as a therapeutic agent in the treatment of other Besnoitia spp [4].
• We suggest that the name Besnoitia caprae be adopted for the caprine pathogen [8].
• It is concluded that oxytetracycline has some therapeutic potential against Besnoitia besnoiti and that rabbits are suitable models for therapeutic trials [9].

References