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Gene Review

Trpv1  -  transient receptor potential cation...

Mus musculus

Synonyms: OTRPC1, Osm-9-like TRP channel 1, TRPV1alpha, TRPV1beta, Transient receptor potential cation channel subfamily V member 1, ...
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Disease relevance of Trpv1


High impact information on Trpv1


Chemical compound and disease context of Trpv1


Biological context of Trpv1


Anatomical context of Trpv1


Associations of Trpv1 with chemical compounds

  • Unlike their wild-type counterparts, SON neurons in Trpv1 knockout (Trpv1(-/-)) mice could not generate ruthenium red-sensitive increases in membrane conductance and depolarizing potentials in response to hyperosmotic stimulation [18].
  • Moreover, Trpv1(-/-) mice showed a pronounced serum hyperosmolality under basal conditions and severely compromised AVP responses to osmotic stimulation in vivo [18].
  • A subset of animals were administered the VR-1 antagonist capsazepine, famotidine, or omeprazole one hour before surgery [1].
  • Here, we show that bradykinin- or NGF-mediated potentiation of thermal sensitivity in vivo requires expression of VR1, a heat-activated ion channel on sensory neurons [19].
  • SR141716A, per se, but not the vanilloid VR1 receptor antagonist capsazepine, enhanced fluid accumulation induced by CT, whereas the selective inhibitor of anandamide cellular uptake, VDM11, prevented CT-induced fluid accumulation [20].

Regulatory relationships of Trpv1


Other interactions of Trpv1

  • In addition, OSMR-positive neurons decreased, resulting in the reduced number of VR1/P2X3/OSMR-triple positive neurons [24].
  • Furthermore, the CB(1) and VR1 receptor antagonists did not block the effects of AEA on Fos immunoreactivity [25].
  • Antagonism of either the vanilloid receptor transient receptor vanilloid 1 or the substance P receptor NK1-R had no effect on elastase-mediated lung injury in NEP-deficient mice [26].
  • A high expression level of the VR-1 like protein (VRL-1) was observed in peritoneal macrophages, while the expression of VR-1 was not detected [27].
  • Methylation of the amide group decreased the activity at VR1, AMT, and FAAH [28].

Analytical, diagnostic and therapeutic context of Trpv1

  • METHODS: Oesophagitis was induced by pyloric ligation in wild-type and VR-1 deficient mice [1].
  • Here we have disrupted the mouse VR1 gene using standard gene targeting techniques [7].
  • By in situ hybridization and immunostaining, we confirmed that TGR7 mRNA was co-expressed in the small diameter neurons with P2X3 and VR1, both in rat and monkey dorsal root ganglia [29].
  • 2. Whole cell voltage clamp techniques were used to examine the efficacy of AEA and related analogues methanandamide and N-(4-hydroxyphenyl)-arachidonylamide (AM404) at native VR1 receptors in acutely isolated mouse trigeminal neurons [30].
  • [3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution [31].


  1. Attenuation of acid induced oesophagitis in VR-1 deficient mice. Fujino, K., de la Fuente, S.G., Takami, Y., Takahashi, T., Mantyh, C.R. Gut (2006) [Pubmed]
  2. Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. Nathan, J.D., Patel, A.A., McVey, D.C., Thomas, J.E., Prpic, V., Vigna, S.R., Liddle, R.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  3. Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model. Bánvölgyi, A., Pálinkás, L., Berki, T., Clark, N., Grant, A.D., Helyes, Z., Pozsgai, G., Szolcsányi, J., Brain, S.D., Pintér, E. J. Neuroimmunol. (2005) [Pubmed]
  4. Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila. Lu, T., Newton, C., Perkins, I., Friedman, H., Klein, T.W. Eur. J. Pharmacol. (2006) [Pubmed]
  5. Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. Moriyama, T., Iida, T., Kobayashi, K., Higashi, T., Fukuoka, T., Tsumura, H., Leon, C., Suzuki, N., Inoue, K., Gachet, C., Noguchi, K., Tominaga, M. J. Neurosci. (2003) [Pubmed]
  6. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Story, G.M., Peier, A.M., Reeve, A.J., Eid, S.R., Mosbacher, J., Hricik, T.R., Earley, T.J., Hergarden, A.C., Andersson, D.A., Hwang, S.W., McIntyre, P., Jegla, T., Bevan, S., Patapoutian, A. Cell (2003) [Pubmed]
  7. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Davis, J.B., Gray, J., Gunthorpe, M.J., Hatcher, J.P., Davey, P.T., Overend, P., Harries, M.H., Latcham, J., Clapham, C., Atkinson, K., Hughes, S.A., Rance, K., Grau, E., Harper, A.J., Pugh, P.L., Rogers, D.C., Bingham, S., Randall, A., Sheardown, S.A. Nature (2000) [Pubmed]
  8. Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. Massi, P., Vaccani, A., Ceruti, S., Colombo, A., Abbracchio, M.P., Parolaro, D. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  9. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Offertáler, L., Mo, F.M., Bátkai, S., Liu, J., Begg, M., Razdan, R.K., Martin, B.R., Bukoski, R.D., Kunos, G. Mol. Pharmacol. (2003) [Pubmed]
  10. Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia. Hu, H.J., Bhave, G., Gereau, R.W. J. Neurosci. (2002) [Pubmed]
  11. Contribution of sensory neurons to sex difference in the development of stress-induced gastric mucosal injury in mice. Shimozawa, N., Okajima, K., Harada, N., Arai, M., Ishida, Y., Shimada, S., Kurihara, H., Nakagata, N. Gastroenterology (2006) [Pubmed]
  12. Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells. Basu, S., Srivastava, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways. Olah, Z., Karai, L., Iadarola, M.J. J. Biol. Chem. (2002) [Pubmed]
  14. The "dark side" of endocannabinoids: a neurotoxic role for anandamide. Cernak, I., Vink, R., Natale, J., Stoica, B., Lea, P.M., Movsesyan, V., Ahmed, F., Knoblach, S.M., Fricke, S.T., Faden, A.I. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  15. Daily body temperature rhythm and heat tolerance in TRPV1 knockout and capsaicin pretreated mice. Szelényi, Z., Hummel, Z., Szolcsányi, J., Davis, J.B. Eur. J. Neurosci. (2004) [Pubmed]
  16. Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat. Sanderson Nydahl, K., Skinner, K., Julius, D., Basbaum, A.I. Eur. J. Neurosci. (2004) [Pubmed]
  17. Expression of substance P and vanilloid receptor (VR1) in trigeminal sensory neurons projecting to the mouse nasal mucosa. Dinh, Q.T., Groneberg, D.A., Mingomataj, E., Peiser, C., Heppt, W., Dinh, S., Arck, P.C., Klapp, B.F., Fischer, A. Neuropeptides (2003) [Pubmed]
  18. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Naeini, R.S., Witty, M.F., Séguéla, P., Bourque, C.W. Nat. Neurosci. (2006) [Pubmed]
  19. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Chuang , H.H., Prescott, E.D., Kong, H., Shields, S., Jordt, S.E., Basbaum, A.I., Chao, M.V., Julius, D. Nature (2001) [Pubmed]
  20. An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice. Izzo, A.A., Capasso, F., Costagliola, A., Bisogno, T., Marsicano, G., Ligresti, A., Matias, I., Capasso, R., Pinto, L., Borrelli, F., Cecio, A., Lutz, B., Mascolo, N., Di Marzo, V. Gastroenterology (2003) [Pubmed]
  21. Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons. Tamura, S., Morikawa, Y., Miyajima, A., Senba, E. Eur. J. Neurosci. (2003) [Pubmed]
  22. Cardiovascular pharmacology of anandamide. Högestätt, E.D., Zygmunt, P.M. Prostaglandins Leukot. Essent. Fatty Acids (2002) [Pubmed]
  23. Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha. Jin, X., Gereau, R.W. J. Neurosci. (2006) [Pubmed]
  24. Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia. Morikawa, Y., Tamura, S., Minehata, K., Donovan, P.J., Miyajima, A., Senba, E. J. Neurosci. (2004) [Pubmed]
  25. The endogenous cannabinoid, anandamide, activates the hypothalamo-pituitary-adrenal axis in CB1 cannabinoid receptor knockout mice. Wenger, T., Ledent, C., Tramu, G. Neuroendocrinology (2003) [Pubmed]
  26. Neutral endopeptidase determines the severity of pancreatitis-associated lung injury. Day, A.L., Wick, E., Jordan, T.H., Jaffray, C.E., Bunnett, N.W., Grady, E.F., Kirkwood, K.S. J. Surg. Res. (2005) [Pubmed]
  27. Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages. Kim, C.S., Kawada, T., Kim, B.S., Han, I.S., Choe, S.Y., Kurata, T., Yu, R. Cell. Signal. (2003) [Pubmed]
  28. A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. Di Marzo, V., Griffin, G., De Petrocellis, L., Brandi, I., Bisogno, T., Williams, W., Grier, M.C., Kulasegram, S., Mahadevan, A., Razdan, R.K., Martin, B.R. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  29. Identification of a G protein-coupled receptor specifically responsive to beta-alanine. Shinohara, T., Harada, M., Ogi, K., Maruyama, M., Fujii, R., Tanaka, H., Fukusumi, S., Komatsu, H., Hosoya, M., Noguchi, Y., Watanabe, T., Moriya, T., Itoh, Y., Hinuma, S. J. Biol. Chem. (2004) [Pubmed]
  30. Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. Roberts, L.A., Christie, M.J., Connor, M. Br. J. Pharmacol. (2002) [Pubmed]
  31. [3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution. Roberts, J.C., Davis, J.B., Benham, C.D. Brain Res. (2004) [Pubmed]
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