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MeSH Review


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Disease relevance of Cupressus


High impact information on Cupressus

  • An allergenic extract from Cupressus arizonica pollen was prepared with two extraction steps followed by ammonium sulfate precipitation, giving a protein yield of about 3% [2].
  • Recently, the Cupressus arizonica major allergen, Cup a1, has been cloned and expressed [3].
  • A monoclonal antibody (5E6), specific for a carbohydrate epitope detectable on components of Cupressus arizonica pollen extract, has been produced and characterized [4].
  • Roles of jasmonate and ethylene signalling and their interaction in yeast elicitor-induced biosynthesis of a phytoalexin, beta-thujaplicin, were investigated in Cupressus lusitanica cell cultures [5].
  • RESULTS: Direct RAST, RAST inhibition, and SDS-PAGE data indicated that the PPT C. arizonica pollen extract showed the most allergenic potential, and it can be considered representative of the Cupressus spp [6].

Biological context of Cupressus


Associations of Cupressus with chemical compounds


Gene context of Cupressus

  • CASE REPORT: a 66-year-old woman presented with symptoms of allergic rhinitis and asthma due to sensitization to Cupressus arizonica [13].
  • CONCLUSION: This study has shown that: The KCNO modified Cupressus arizonica extract has a reduced IgE binding capacity; This monomeric allergoid is safe and effective administrated by the oromucosal route in clinical respiratory allergy to Cupressaceae and devoid of any side effect [14].

Analytical, diagnostic and therapeutic context of Cupressus


  1. Refolding of the Cupressus arizonica major pollen allergen Cup a1.02 overexpressed in Escherichia coli. Rea, G., Iacovacci, P., Ferrante, P., Zelli, M., Brunetto, B., Lamba, D., Boffi, A., Pini, C., Federico, R. Protein Expr. Purif. (2004) [Pubmed]
  2. Allergens of Arizona cypress (Cupressus arizonica) pollen: characterization of the pollen extract and identification of the allergenic components. Di Felice, G., Caiaffa, M.F., Bariletto, G., Afferni, C., Di Paola, R., Mari, A., Palumbo, S., Tinghino, R., Sallusto, F., Tursi, A. J. Allergy Clin. Immunol. (1994) [Pubmed]
  3. Comparison between the native glycosylated and the recombinant Cup a1 allergen: role of carbohydrates in the histamine release from basophils. Iacovacci, P., Afferni, C., Butteroni, C., Pironi, L., Puggioni, E.M., Orlandi, A., Barletta, B., Tinghino, R., Ariano, R., Panzani, R.C., Di Felice, G., Pini, C. Clin. Exp. Allergy (2002) [Pubmed]
  4. A monoclonal antibody specific for a carbohydrate epitope recognizes an IgE-binding determinant shared by taxonomically unrelated allergenic pollens. Iacovacci, P., Pini, C., Afferni, C., Barletta, B., Tinghino, R., Schininà, E., Federico, R., Mari, A., Di Felice, G. Clin. Exp. Allergy (2001) [Pubmed]
  5. Jasmonate and ethylene signalling and their interaction are integral parts of the elicitor signalling pathway leading to beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures. Zhao, J., Zheng, S.H., Fujita, K., Sakai, K. J. Exp. Bot. (2004) [Pubmed]
  6. Allergenic relevance of Cupressus arizonica pollen extract and biological characterization of the allergoid. Mistrello, G., Roncarolo, D., Zanoni, D., Zanotta, S., Amato, S., Falagiani, P., Ariano, R. Int. Arch. Allergy Immunol. (2002) [Pubmed]
  7. Signal transduction and metabolic flux of beta-thujaplicin and monoterpene biosynthesis in elicited Cupressus lusitanica cell cultures. Zhao, J., Matsunaga, Y., Fujita, K., Sakai, K. Metab. Eng. (2006) [Pubmed]
  8. Molecular cloning of major allergen from Cupressus arizonica pollen: Cup a 1. Aceituno, E., Del Pozo, V., Mínguez, A., Arrieta, I., Cortegano, I., Cárdaba, B., Gallardo, S., Rojo, M., Palomino, P., Lahoz, C. Clin. Exp. Allergy (2000) [Pubmed]
  9. Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures. Zhao, J., Sakai, K. J. Exp. Bot. (2003) [Pubmed]
  10. Rapid isolation, characterization, and glycan analysis of Cup a 1, the major allergen of Arizona cypress (Cupressus arizonica) pollen. Alisi, C., Afferni, C., Iacovacci, P., Barletta, B., Tinghino, R., Butteroni, C., Puggioni, E.M., Wilson, I.B., Federico, R., Schininà, M.E., Ariano, R., Di Felice, G., Pini, C. Allergy (2001) [Pubmed]
  11. Feedback regulation of beta-thujaplicin production and formation of its methyl ether in a suspension culture of Cupressus lusitanica. Yamada, J., Fujita, K., Sakai, K. Phytochemistry (2002) [Pubmed]
  12. Production of beta-thujaplicin in Cupressus lusitanica suspension cultures fed with organic acids and monoterpenes. Zhao, J., Fujita, K., Sakai, K. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
  13. Vasculitis during immunotherapy treatment in a patient with allergy to Cupressus arizonica. Sánchez-Morillas, L., Reaño Martos, M., Iglesias Cadarso, A., Pérez Pimiento, A., Rodríguez Mosquera, M., Domínguez Lázaro, A.R. Allergologia et immunopathologia. (2005) [Pubmed]
  14. Efficacy of sublingual coseasonal immunotherapy with a monomeric allergoid in Cupressaceae pollen allergy--preliminary data. Ariano, R., Panzani, R.C., Mistrello, G. Allergie et immunologie. (2005) [Pubmed]
  15. Quantification of the major allergen from cypress (Cupressus arizonica) pollen, Cup a 1, by monoclonal antibody-based ELISA. Arilla, M.C., Ibarrola, I., García, R., de la Hoz, B., Martínez, A., Asturias, J.A. Int. Arch. Allergy Immunol. (2004) [Pubmed]
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