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Chemical Compound Review

Hinokitol     2-hydroxy-6-propan-2-yl- cyclohepta-2,4,6...

Synonyms: hinokitiol, PubChem11045, CHEMBL48310, Bio-0320, NCIMech_000141, ...
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Disease relevance of C09904


High impact information on C09904


Chemical compound and disease context of C09904


Biological context of C09904


Anatomical context of C09904


Associations of C09904 with other chemical compounds


Gene context of C09904


Analytical, diagnostic and therapeutic context of C09904


  1. In vitro inhibitory effects of hinokitiol on proliferation of Chlamydia trachomatis. Yamano, H., Yamazaki, T., Sato, K., Shiga, S., Hagiwara, T., Ouchi, K., Kishimoto, T. Antimicrob. Agents Chemother. (2005) [Pubmed]
  2. Antibacterial effect of beta-thujaplicin on staphylococci isolated from atopic dermatitis: relationship between changes in the number of viable bacterial cells and clinical improvement in an eczematous lesion of atopic dermatitis. Arima, Y., Nakai, Y., Hayakawa, R., Nishino, T. J. Antimicrob. Chemother. (2003) [Pubmed]
  3. Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines. Liu, S., Yamauchi, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. Evaluation of developmental toxicity of beta-thujaplicin (hinokitiol) following oral administration during organogenesis in rats. Ema, M., Harazono, A., Fujii, S., Kawashima, K. Food Chem. Toxicol. (2004) [Pubmed]
  5. Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes. Baba, T., Nakano, H., Tamai, K., Sawamura, D., Hanada, K., Hashimoto, I., Arima, Y. J. Invest. Dermatol. (1998) [Pubmed]
  6. Mechanism of mitochondrial dysfunction and cytotoxicity induced by tropolones in isolated rat hepatocytes. Nakagawa, Y., Tayama, K. Chem. Biol. Interact. (1998) [Pubmed]
  7. Induction of embryonal carcinoma cell differentiation by deferoxamine, a potent therapeutic iron chelator. Tanaka, T., Muto, N., Ido, Y., Itoh, N., Tanaka, K. Biochim. Biophys. Acta (1997) [Pubmed]
  8. Oxidative stress in plant cell culture: a role in production of beta-thujaplicin by Cupresssus lusitanica suspension culture. Zhao, J., Fujita, K., Sakai, K. Biotechnol. Bioeng. (2005) [Pubmed]
  9. Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. Ido, Y., Muto, N., Inada, A., Kohroki, J., Mano, M., Odani, T., Itoh, N., Yamamoto, K., Tanaka, K. Cell Prolif. (1999) [Pubmed]
  10. Improved beta-thujaplicin production in Cupressus lusitanica suspension cultures by fungal elicitor and methyl jasmonate. Zhao, J., Fujita, K., Yamada, J., Sakai, K. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
  11. Jasmonate and ethylene signalling and their interaction are integral parts of the elicitor signalling pathway leading to beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures. Zhao, J., Zheng, S.H., Fujita, K., Sakai, K. J. Exp. Bot. (2004) [Pubmed]
  12. Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures. Zhao, J., Sakai, K. J. Exp. Bot. (2003) [Pubmed]
  13. Feedback regulation of beta-thujaplicin production and formation of its methyl ether in a suspension culture of Cupressus lusitanica. Yamada, J., Fujita, K., Sakai, K. Phytochemistry (2002) [Pubmed]
  14. Differential regulation of melanosomal proteins after hinokitiol treatment. Choi, Y.G., Bae, E.J., Kim, D.S., Park, S.H., Kwon, S.B., Na, J.I., Park, K.C. J. Dermatol. Sci. (2006) [Pubmed]
  15. Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis. Kim, D.S., Kim, S.Y., Park, S.H., Choi, Y.G., Kwon, S.B., Kim, M.K., Na, J.I., Youn, S.W., Park, K.C. Biol. Pharm. Bull. (2005) [Pubmed]
  16. Hinokitiol, a selective inhibitor of the platelet-type isozyme of arachidonate 12-lipoxygenase. Suzuki, H., Ueda, T., Juránek, I., Yamamoto, S., Katoh, T., Node, M., Suzuki, T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  17. Effects of zinc oxide on the attachment of Staphylococcus aureus strains. Akiyama, H., Yamasaki, O., Kanzaki, H., Tada, J., Arata, J. J. Dermatol. Sci. (1998) [Pubmed]
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