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MeSH Review


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Disease relevance of Cupressaceae


High impact information on Cupressaceae

  • Western blot analysis showed that Pla a 2 is present in pollen and stems and has IgG cross-reactivity with a PG from tomato and pectate lyases from Cupressaceae pollen [3].
  • IgE screening of the library was performed with a pool of sera from subjects allergic to Cupressaceae [4].
  • High-resolution 13C MAS NMR spectroscopy was used to profile a range of primary and secondary metabolites in vivo in intact whole seeds of eight different conifer species native to North America, including six of the Pinaceae family and two of the Cupressaceae family [5].
  • There was a statistically significant correlation between simultaneous weekly average pollen levels in Philadelphia and in Cherry Hill (Acer, r(p) = 0.987, Quercus, r(p) = 0.645, Betula, r(p) = 0.896, Pinus, r(p) = 0.732, Cupressaceae, r(p) = 0.695, Poaceae, r(p) = 0.950, Ambrosia, r(p) = 0.903, and Rumex, r(p) = 0.572, P <0.001) [6].
  • In particular, the MC major allergen, gp40, is cross-reactive with 40 to 42 kD proteins of the other Cupressaceae and with the Japanese cedar major allergen of 46 kD [7].

Associations of Cupressaceae with chemical compounds


Gene context of Cupressaceae

  • Formosadimers A, B, and C from the Bark of Calocedrus macrolepis var. formosana [13].
  • (Cupressaceae) and Phyllocladus Rich. ex Mirb [14].
  • From 110 patients with respiratory allergies and positive-SPT, only three subjects (2.7%) were SPT-positive to Cupressaceae [15].
  • The detection of high levels of Cupressaceae pollen concentration in the air from January to April for several years in our area prompted analysis of the incidence and allergenic significance of sensitivity to this pollen [16].
  • In addition, one can speculate that an antigen in Cupressus sempervirens is cross-reactive with SBP, the major allergen of Sugi, suggesting that there is a closer relationship between the Taxodiaceae family and the Cupressaceae family than between these two families and the other families of the gymnosperms [17].


  1. IgE-mediated allergic rhinitis and conjunctivitis caused by Calocedrus decurrens (incense cedar). Cavagni, G., Caffarelli, C., Spattini, A., Riva, G. Allergy (2003) [Pubmed]
  2. Variation of podophyllotoxin in leaves of Eastern Red Cedar (Juniperus virginiana). Cushman, K.E., Maqbool, M., Gerard, P.D., Bedir, E., Lata, H., Moraes, R.M. Planta Med. (2003) [Pubmed]
  3. Identification of a polygalacturonase as a major allergen (Pla a 2) from Platanus acerifolia pollen. Ibarrola, I., Arilla, M.C., Martínez, A., Asturias, J.A. J. Allergy Clin. Immunol. (2004) [Pubmed]
  4. Molecular characterization of a cross-reactive Juniperus oxycedrus pollen allergen, Jun o 2: a novel calcium-binding allergen. Tinghino, R., Barletta, B., Palumbo, S., Afferni, C., Iacovacci, P., Mari, A., Di Felice, G., Pini, C. J. Allergy Clin. Immunol. (1998) [Pubmed]
  5. In vivo 13C NMR metabolite profiling: potential for understanding and assessing conifer seed quality. Terskikh, V.V., Feurtado, J.A., Borchardt, S., Giblin, M., Abrams, S.R., Kermode, A.R. J. Exp. Bot. (2005) [Pubmed]
  6. A comparative, volumetric survey of airborne pollen in Philadelphia, Pennsylvania (1991-1997) and Cherry Hill, New Jersey (1995-1997). Dvorin, D.J., Lee, J.J., Belecanech, G.A., Goldstein, M.F., Dunsky, E.H. Ann. Allergy Asthma Immunol. (2001) [Pubmed]
  7. Cross-reactivity among conifer pollens. Schwietz, L.A., Goetz, D.W., Whisman, B.A., Reid, M.J. Ann. Allergy Asthma Immunol. (2000) [Pubmed]
  8. Antifungal biflavones from Cupressocyparis leylandii. Krauze-Baranowska, M., Cisowski, W., Wiwart, M., Madziar, B. Planta Med. (1999) [Pubmed]
  9. The nonpeptide alpha-eudexp6l from Juniperus virginiana Linn. (Cupressaceae) inhibits omega-agatoxin IVA-sensitive Ca2+ currents and synaptosomal 45Ca2+ uptake. Asakura, K., Kanemasa, T., Minagawa, K., Kagawa, K., Ninomiya, M. Brain Res. (1999) [Pubmed]
  10. Two new compounds from the leaves of Calocedrus microlepic var. formosana. Chien, S.C., Liu, H.K., Kuo, Y.H. Chem. Pharm. Bull. (2004) [Pubmed]
  11. Separation and identification of Taxifolin 3-O-glucoside isomers from Chamaecyparis obtusa (Cupressaceae). Sakushima, A., Ohno, K., Coskun, M., Seki, K., Ohkura, K. Natural product letters. (2002) [Pubmed]
  12. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. Logarto Parra, A., Silva Yhebra, R., Guerra Sardiñas, I., Iglesias Buela, L. Phytomedicine (2001) [Pubmed]
  13. Formosadimers A, B, and C from the Bark of Calocedrus macrolepis var. formosana. Hsieh, C.L., Tseng, M.H., Kuo, Y.H. Chem. Pharm. Bull. (2005) [Pubmed]
  14. Wettable and unsinkable: the hydrodynamics of saccate pollen grains in relation to the pollination mechanism in the two New Zealand species of Prumnopitys Phil. (Podocarpaceae). Salter, J., Murray, B.G., Braggins, J.E. Ann. Bot. (2002) [Pubmed]
  15. Cupressaceae in Tirana (Albania) 1996-1998 aerobiological data and prevalence of Cupresaceae sensitization in allergic patients. Priftanji, A., Gjebrea, E., Shkurti, A. Allergie et immunologie. (2000) [Pubmed]
  16. Sensitivity to Cupressus: allergenic significance in Córdoba (Spain). Guerra, F., Daza, J.C., Miguel, R., Moreno, C., Galán, C., Domínguez, E., Sánchez Guijo, P. Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología. (1996) [Pubmed]
  17. Cross-reactivity between the pollens of Cupressus sempervirens (common cypress) and of Cryptomeria japonica (Japanese cedar). Panzani, R., Yasueda, H., Shimizu, T., Shida, T. Annals of allergy. (1986) [Pubmed]
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