Disease relevance of Nasal Provocation Tests

• In 162 patients with allergic rhinitis due to immediate hypersensitivity, nasal provocation tests (NPT) were supplemented by recording of the eosinophils in the nasal secretions (NS) [1].
• METHODS: Twenty-six patients with perennial rhinitis and 25 controls underwent skin prick and nasal provocation tests to standardized Der p allergen extract [2].
• Among adult patients with bronchial asthma and/or allergic rhinitis undergoing allergological investigation with skin test, nasal provocation test and RAST, 1129 answered a questionaire regarding food sensitivity (FS) [3].
• Nasal provocation tests in the diagnosis of urticaria induced by acetylsalicylic acid [4].
• This pediatric cytological and clinical study aimed at assessing the value of nasal eosinophilia during nasal provocation tests for identifying an offending allergen [5].

High impact information on Nasal Provocation Tests

• To investigate the cellular sources and the secretory control of these nasal proteins in vivo, 34 adult subjects underwent nasal provocation tests with methacholine (MC), histamine (H), and gustatory stimuli [6].
• OBJECTIVE: We sought to compare levocetirizine and desloratadine in a nasal provocation test (NPT) with grass pollen [7].
• OBJECTIVE: We sought to compare the effects of terfenadine and fexofenadine on nasal provocation tests with allergen [8].
• Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen [8].
• The clinical significance of cross-reactive IgE antibodies was studied with histamine release experiments and nasal provocation tests [9].

Chemical compound and disease context of Nasal Provocation Tests

• It has been confirmed that the histamine nasal provocation test can differentiate between controls and non-allergic rhinitis patients [10].
• The effects of terfenadine and pseudoephedrine, alone and in combination, have been assessed in a nasal provocation test and in perennial rhinitis [11].

Anatomical context of Nasal Provocation Tests

• A nasal provocation test was performed by consecutively placing allergen discs on the nasal mucosa of patients with pollinosis [12].

Associations of Nasal Provocation Tests with chemical compounds

• Nasal provocation test with lysine-aspirin for diagnosis of aspirin-sensitive asthma [13].
• Fenoterol hydrobromide, 1 mg/ml, was given by nasal spray in doses between 204 and 576 microgram in an attempt to reduce nasal sensitivity to Lolium perenne allergen in a nasal provocation test during a 2-hr period following the drug [14].
• When patients underwent nasal provocation tests with allergen, ebastine significantly increased the mean number of pollen grains required to induce an allergic response [15].
• OBJECTIVE : The aim of this study was to compare natural birch pollen extract (BPE) and recombinant Betula verrucosa (rBet v 1) for their diagnostic value comparing skin prick tests (SPTS) and nasal provocation tests (NPTS) with specific IgE in the serum [16].
• Comparison of levocabastine, a new selective H1-receptor antagonist, and disodium cromoglycate, in a nasal provocation test with allergen [17].

Gene context of Nasal Provocation Tests

• Nasal ECP and nasal tryptase after specific nasal provocation tests were significantly reduced as compared to baseline values (p = 0.0043 and 0.0195, respectively) in the third year of active treatment [18].
• Specific Nasal Provocation Test (NPT) for grass and aspecific bronchial challenge were done; sera were analyzed for specific IgE and IgG [19].
• Nasal provocation tests with histamine and methacholine were carried out on 25 healthy men in an effort to assess the dynamic changes of albumin, total IgA, secretory IgA and lactoferrin concentrations in the nasal secretion [20].
• Skin tests (SPT), scratch tests (ST), nasal provocation tests (NPT) and serological examinations (IgE) were performed [21].

Analytical, diagnostic and therapeutic context of Nasal Provocation Tests

• We aimed to determine whether the nasal provocation test (NPT) with allergen could be used as a diagnostic test in asthmatic children with or without allergic rhinitis, and whether it had any effects on pulmonary function tests and arterial oxygen saturation (SaO2) values [22].
• Of the remaining children, 290 were further examined: methacholine test was positive in 109, exercise test was positive in 67, nasal provocation test with histamine was positive in 244, and rhinodilation test with tramazoline was positive in 206 [23].
• The nasal provocation test was considered positive when insufflation of the allergen increased nasal eosinophilia by more than 10%, provided that the prechallenge proportion of eosinophils was less than 50% [5].
• Immunotherapy for allergic rhinitis was only considered justifiable when the nasal provocation test was positive [24].

References