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Disease relevance of Phytolaccaceae


High impact information on Phytolaccaceae


Biological context of Phytolaccaceae

  • Phytolaccaceae extracts (2.5-20 microg/ml) inhibited the high glucose-induced [3H]thymidine incorporation in a dose-dependent manner, and the concentrations tested here did not affect to the cell viability [8].

Anatomical context of Phytolaccaceae


Associations of Phytolaccaceae with chemical compounds

  • (Phytolaccaceae), which occurs in Southern China, has been found to be a new manganese hyperaccumulator by means of field surveys on Mn-rich soils and by glasshouse experiments [5].
  • A mixture of cerebrosides, called poke-weed cerebrosides, was purified from Phytolaccae Radix (Phytolaccaceae) and characterized as 1-O-beta-D-glucopyranosides of phytosphingosine type ceramides comprised of a common long chain base (2S,3S,4R,8Z)-2-amino-8-octadecene-1,3,4-triol and fatty acids [9].
  • Two diastereomers of S-benzyl-L-cysteine sulfoxide have been isolated from fresh roots of Petiveria alliacea [7].
  • For the hexane extracts of Petiveria alliacea (Phytolaccaceae) and Tridax procumbens (Asteraceae) a marked inhibition of trypomastigotes has been found [10].

Gene context of Phytolaccaceae

  • Taken together, these results indicate that Phytolaccaceae inhibits the high glucose-induced GMCs proliferation partially through suppressing accumulation of ECM components and TGF-beta production, suggesting that Phytolaccaceae may be a promising agent for treating the development and progression of diabetic glomerulopathy [8].
  • Exposure of the GMCs to 20 mM glucose caused both ECM (collagen and fibronectin) accumulation and TGF-beta secretion, and these changes were significantly diminished by treatment of GMCs with Phytolaccaceae (10 microg/ml) [8].


  1. Cirsimarin and cirsimaritin, flavonoids of Microtea debilis (Phytolaccaceae) with adenosine antagonistic properties in rats: leads for new therapeutics in acute renal failure. Hasrat, J.A., De Bruyne, T., De Backer, J.P., Vauquelin, G., Vlietinck, A.J. J. Pharm. Pharmacol. (1997) [Pubmed]
  2. Cytokine profile and natural killer cell activity in Listeria monocytogenes infected mice treated orally with Petiveria alliacea extract. Queiroz, M.L., Quadros, M.R., Santos, L.M. Immunopharmacology and immunotoxicology. (2000) [Pubmed]
  3. Lipolytic activity of cirsimarin extracted from Microtea debilis. Girotti, C., Ginet, M., Demarne, F.C., Lagarde, M., Géloën, A. Planta Med. (2005) [Pubmed]
  4. Application of semi-preparative high-performance liquid chromatography to difficult natural product separations. Décosterd, L.A., Dorsaz, A.C., Hostettmann, K. J. Chromatogr. (1987) [Pubmed]
  5. Manganese uptake and accumulation by the hyperaccumulator plant Phytolacca acinosa Roxb. (Phytolaccaceae). Xue, S.G., Chen, Y.X., Reeves, R.D., Baker, A.J., Lin, Q., Fernando, D.R. Environ. Pollut. (2004) [Pubmed]
  6. S-Substituted cysteine derivatives and thiosulfinate formation in Petiveria alliacea-part II. Kubec, R., Kim, S., Musah, R.A. Phytochemistry (2002) [Pubmed]
  7. Cysteine sulfoxide derivatives in Petiveria alliacea. Kubec, R., Musah, R.A. Phytochemistry (2001) [Pubmed]
  8. Phytolacca americana inhibits the high glucose-induced mesangial proliferation via suppressing extracellular matrix accumulation and TGF-beta production. Jeong, S.I., Kim, K.J., Choo, Y.K., Keum, K.S., Choi, B.K., Jung, K.Y. Phytomedicine (2004) [Pubmed]
  9. Cyclooxygenase-2 inhibitory cerebrosides from phytolaccae radix. Kang, S.S., Kim, J.S., Son, K.H., Kim, H.P., Chang, H.W. Chem. Pharm. Bull. (2001) [Pubmed]
  10. Plants used in Guatemala for the treatment of protozoal infections: II. Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cruzi. Berger, I., Barrientos, A.C., Cáceres, A., Hernández, M., Rastrelli, L., Passreiter, C.M., Kubelka, W. Journal of ethnopharmacology. (1998) [Pubmed]
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