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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Clusiaceae


High impact information on Clusiaceae

  • YCT is a semipurified extract from Cratoxylum cochinchinense that has antioxidant properties and contains mostly mangiferin [2].
  • A new natural xanthone, 1,3-dihydroxy-6,7-dimethoxy-2,8-diprenylxanthone, together with four known compounds, fuscaxanthone C, 1,7-dihydroxyxanthone, 3-geranyloxy-6-methyl-1,8-dihydroxyanthraquinone and 2-geranylemodin were isolated from the stem bark of Cratoxylum arborescens (Vahl) Blume [3].
  • A phytochemical investigation of the 80% ethanolic extract of stem bark of Vismia orientalis Engl. (Guttiferae or Clusiaceae), a plant used in traditional medicine in Tanzania, resulted in the isolation and spectroscopic characterisation of 3-geranyloxy-6-methyl-1,8-dihydroxyanthraquinone, emodin, vismione D and bianthrone A1 [4].
  • Three compounds, namely the interesting biflavanonol GB-2(naringenin 1-3, 11-8-dihydroquercetin, 1), 1-4',1-5,11-5,1-7,11-7-pentahydroxyflavanone(l-3,11-8)chromone [naringenin-(3 -8) 5,7-dihydroxychromone, 21 and stigmasterol, have been isolated from the leaves of Cratoxylum neriifolium Kurz [5].
  • The protein kinase C (PKC) modulatory effects of euxanthone, isolated from the wood of Cratoxylum maingayi, on isoforms alpha, betaI, delta, eta and zeta were characterised using an alternative in vivo yeast phenotypic assay [6].

Biological context of Clusiaceae


Associations of Clusiaceae with chemical compounds


Gene context of Clusiaceae

  • Calophyllum brasiliense (Clusiaceae) is a big tree from the Tropical Rain Forests of the American continent [13].
  • 6-Geranyloxy-3-methyl-1,8-dihydroxyanthrone, a novel antileukemic agent from Psorospermum febrifugum Sprach var. ferrugineum (Hook. fil) [14].

Analytical, diagnostic and therapeutic context of Clusiaceae


  1. An antibacterial vitamin E derivative from Tovomitopsis psychotriifolia. Setzer, W.N., Green, T.J., Lawton, R.O., Moriarity, D.M., Bates, R.B., Caldera, S., Haber, W.A. Planta Med. (1995) [Pubmed]
  2. Mechanism of cell death induced by an antioxidant extract of Cratoxylum cochinchinense (YCT) in Jurkat T cells: the role of reactive oxygen species and calcium. Tang, S.Y., Whiteman, M., Jenner, A., Peng, Z.F., Halliwell, B. Free Radic. Biol. Med. (2004) [Pubmed]
  3. Cytotoxic constituents from Cratoxylum arborescens. Pattanaprateeb, P., Ruangrungsi, N., Cordell, G.A. Planta Med. (2005) [Pubmed]
  4. Anthranoid compounds with antiprotozoal activity from Vismia orientalis. Mbwambo, Z.H., Apers, S., Moshi, M.J., Kapingu, M.C., Van Miert, S., Claeys, M., Brun, R., Cos, P., Pieters, L., Vlietinck, A. Planta Med. (2004) [Pubmed]
  5. Conformational analysis of the biflavanoid GB2 and a polyhydroxylated flavanone-chromone of Cratoxylum neriifolium. Kumar, V., Brecht, V., Frahm, A.W. Planta Med. (2004) [Pubmed]
  6. Differential activation of protein kinase C isoforms by euxanthone, revealed by an in vivo yeast phenotypic assay. Saraiva, L., Fresco, P., Pinto, E., Kijjoa, A., Gonzalez, M.J., Gonçalves, J. Planta Med. (2002) [Pubmed]
  7. Pharmacodynamic study of Hypericum perforatum L. Jakovljević, V., Popović, M., Mimica-Dukić, N., Sabo, A., Gvozdenović, L. Phytomedicine (2000) [Pubmed]
  8. Supercritical fluid extraction of catechins from Cratoxylum prunifolium dyer and subsequent purification by high-speed counter-current chromatography. Cao, X.L., Tian, Y., Zhang, T.Y., Ito, Y. Journal of chromatography. A. (2000) [Pubmed]
  9. A prenylated xanthone from Allanblackia floribunda. Nkengfack, A.E., Azebaze, G.A., Vardamides, J.C., Fomum, Z.T., van Heerden, F.R. Phytochemistry (2002) [Pubmed]
  10. Cytotoxic and Antimalarial Prenylated Xanthones from Cratoxylum cochinchinense. Laphookhieo, S., Syers, J.K., Kiattansakul, R., Chantrapromma, K. Chem. Pharm. Bull. (2006) [Pubmed]
  11. Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii. Fuller, R.W., Blunt, J.W., Boswell, J.L., Cardellina, J.H., Boyd, M.R. J. Nat. Prod. (1999) [Pubmed]
  12. Allanxanthone B, a polyisoprenylated xanthone from the stem bark of Allanblackia monticola Staner L.C. Azebaze, A.G., Meyer, M., Bodo, B., Nkengfack, A.E. Phytochemistry (2004) [Pubmed]
  13. Cytotoxic effects of mammea type coumarins from Calophyllum brasiliense. Reyes-Chilpa, R., Estrada-Muñiz, E., Apan, T.R., Amekraz, B., Aumelas, A., Jankowski, C.K., Vázquez-Torres, M. Life Sci. (2004) [Pubmed]
  14. 6-Geranyloxy-3-methyl-1,8-dihydroxyanthrone, a novel antileukemic agent from Psorospermum febrifugum Sprach var. ferrugineum (Hook. fil). Amonkar, A., Chang, C.J., Cassady, J.M. Experientia (1981) [Pubmed]
  15. Biological activities of 7-epiclusianone. Alves, T.M., Alves, R., Romanha, A.J., Zani, C.L., dos Santos, M.H., Nagem, T.J. J. Nat. Prod. (1999) [Pubmed]
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