The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

purrenone     1,7-dihydroxyxanthen-9-one

Synonyms: Euxanthone, eyxanthone, AC1NQYRV, CHEMBL389166, CHEBI:4946, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of C10061

 

High impact information on C10061

  • Among the 14 identified proteins, E2F transcription factor 5 (E2F-5) was significantly up-regulated after euxanthone treatment [1].
  • Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma [1].
  • Go6976, a protein kinase C (PKC) alpha/betaI inhibitor, was found to inhibit neuritogenesis and expression of E2F-5 in the euxanthone-treated BU-1 cells, while SH-6, the Akt/PKB inhibitor, had no inhibitory effect [1].
  • In order to elucidate the underlying mechanisms of euxanthone-induced neurite outgrowth, a proteomic approach was employed [1].
  • The present study shows that euxanthone can activate isoforms alpha, betaI, delta, eta and zeta, being more effective on PKC-betaI, -delta, -eta and -zeta than the established PKC activators used (the phorbol ester PMA and arachidonic acid for PKC-zeta) [2].
 

Biological context of C10061

  • The gene silencing of E2F-5 by small interfering RNA (siRNA) was found to abolish the euxanthone-induced neurite outgrowth [1].
  • In this study, the role of protein kinase C (PKC) and the expression of various PKC isoforms in euxanthone-treated BU-1 cells were examined. mRNA phenotyping using the reverse-transcription polymerase chain reaction (RT-PCR) showed that BU-1 cells express six different PKC isoforms, namely PKC-alpha, -beta, -delta, -epsilon, -lambda, and -zeta [3].
  • These results suggested that the vasorelaxation of euxanthone may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway besides the direct inhibition of calcium influx and its vasorelaxant effect is more active on calcium-independent pathway and more sensitive to the initial stage of contraction [4].
 

Anatomical context of C10061

 

Associations of C10061 with other chemical compounds

 

Gene context of C10061

  • These results suggest that the euxanthone-induced differentiation of the neuroblastoma BU-1 cells may be mediated through the differential expression of PKC-alpha, -beta, -delta, -lambda and -zeta isoforms [3].
  • PKC-gamma, -eta, and -theta were not detected in both untreated and euxanthone-treated BU-1 cells [3].
  • Expression of protein kinase C isoforms in euxanthone-induced differentiation of neuroblastoma cells [3].
  • The protein kinase C (PKC) modulatory effects of euxanthone, isolated from the wood of Cratoxylum maingayi, on isoforms alpha, betaI, delta, eta and zeta were characterised using an alternative in vivo yeast phenotypic assay [2].
 

Analytical, diagnostic and therapeutic context of C10061

  • In the present study, two dimensional (2-D) gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight (MALDI-ToF) mass spectrometry were performed to investigate the alterations in protein expression profile of euxanthone-treated BU-1 cells [1].

References

  1. Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. Ha, W.Y., Wu, P.K., Kok, T.W., Leung, K.W., Mak, N.K., Yue, P.Y., Ngai, S.M., Tsai, S.N., Wong, R.N. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  2. Differential activation of protein kinase C isoforms by euxanthone, revealed by an in vivo yeast phenotypic assay. Saraiva, L., Fresco, P., Pinto, E., Kijjoa, A., Gonzalez, M.J., Gonçalves, J. Planta Med. (2002) [Pubmed]
  3. Expression of protein kinase C isoforms in euxanthone-induced differentiation of neuroblastoma cells. Mak, N.K., Lung, H.L., Wong, R.N., Leung, H.W., Tsang, H.Y., Leung, K.N. Planta Med. (2001) [Pubmed]
  4. Vasorelaxant effect of euxanthone in the rat thoracic aorta. Fang, L.H., Mu, Y.M., Lin, L.L., Xiao, P.G., Du, G.H. Vascul. Pharmacol. (2006) [Pubmed]
  5. Xanthones from Calophyllum teysmannii var. inophylloide. Kijjoa, A., Gonzalez, M.J., Afonso, C.M., Pinto, M.M., Anantachoke, C., Herz, W. Phytochemistry (2000) [Pubmed]
  6. Xanthones and benzophenones from Garcinia griffithii and Garcinia mangostana. Nguyen, L.H., Venkatraman, G., Sim, K.Y., Harrison, L.J. Phytochemistry (2005) [Pubmed]
 
WikiGenes - Universities