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Chemical Compound Review

polyphenols     [(2S,3R)-5,7-dihydroxy-2- (3,4,5...

Synonyms: Sunphenon, Teavigo, EGCG, Epigallocate, PF-EGCg 90, ...
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Disease relevance of Tea catechin


High impact information on Tea catechin


Chemical compound and disease context of Tea catechin


Biological context of Tea catechin


Anatomical context of Tea catechin

  • The objective of the present study was to investigate the effects of epigallocatechin-3-gallate (EGCG), the major constituent of green tea, on vasorelaxation and on eNOS expression and activity in endothelial cells [15].
  • Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB [4].
  • Furthermore, compared with their simian virus-transformed counterpart, the parental normal human fibroblasts were much more resistant to EGCG-induced p27(Kip1) protein accumulation and G(1) arrest [19].
  • This inhibition of the proteasome by EGCG in several tumor and transformed cell lines results in the accumulation of two natural proteasome substrates, p27(Kip1) and IkappaB-alpha, an inhibitor of transcription factor NF-kappaB, followed by growth arrest in the G(1) phase of the cell cycle [19].
  • Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells [20].

Associations of Tea catechin with other chemical compounds


Gene context of Tea catechin


Analytical, diagnostic and therapeutic context of Tea catechin


  1. VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia. Lee, Y.K., Bone, N.D., Strege, A.K., Shanafelt, T.D., Jelinek, D.F., Kay, N.E. Blood (2004) [Pubmed]
  2. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. Brusselmans, K., Vrolix, R., Verhoeven, G., Swinnen, J.V. J. Biol. Chem. (2005) [Pubmed]
  3. Suppression of Wnt Signaling by the Green Tea Compound (-)-Epigallocatechin 3-Gallate (EGCG) in Invasive Breast Cancer Cells: REQUIREMENT OF THE TRANSCRIPTIONAL REPRESSOR HBP1. Kim, J., Zhang, X., Rieger-Christ, K.M., Summerhayes, I.C., Wazer, D.E., Paulson, K.E., Yee, A.S. J. Biol. Chem. (2006) [Pubmed]
  4. Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB. Singh, R., Ahmed, S., Islam, N., Goldberg, V.M., Haqqi, T.M. Arthritis Rheum. (2002) [Pubmed]
  5. Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. Aktas, O., Prozorovski, T., Smorodchenko, A., Savaskan, N.E., Lauster, R., Kloetzel, P.M., Infante-Duarte, C., Brocke, S., Zipp, F. J. Immunol. (2004) [Pubmed]
  6. Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. Ahmad, N., Feyes, D.K., Nieminen, A.L., Agarwal, R., Mukhtar, H. J. Natl. Cancer Inst. (1997) [Pubmed]
  7. SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. Amin, A.R., Thakur, V.S., Paul, R.K., Feng, G.S., Qu, C.K., Mukhtar, H., Agarwal, M.L. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  8. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Stresemann, C., Brueckner, B., Musch, T., Stopper, H., Lyko, F. Cancer Res. (2006) [Pubmed]
  9. Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids. Das, A., Banik, N.L., Ray, S.K. Int. J. Cancer (2006) [Pubmed]
  10. EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: Role of JAK/STAT1 signaling and implications for HIV-associated dementia. Giunta, B., Obregon, D., Hou, H., Zeng, J., Sun, N., Nikolic, V., Ehrhart, J., Shytle, D., Fernandez, F., Tan, J. Brain Res. (2006) [Pubmed]
  11. Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture. Kavanagh, K.T., Hafer, L.J., Kim, D.W., Mann, K.K., Sherr, D.H., Rogers, A.E., Sonenshein, G.E. J. Cell. Biochem. (2001) [Pubmed]
  12. Induction of apoptosis in human stomach cancer cells by green tea catechins. Hibasami, H., Komiya, T., Achiwa, Y., Ohnishi, K., Kojima, T., Nakanishi, K., Akashi, K., Hara, Y. Oncol. Rep. (1998) [Pubmed]
  13. Effect of tea polyphenols on growth of oral squamous carcinoma cells in vitro. Elattar, T.M., Virji, A.S. Anticancer Res. (2000) [Pubmed]
  14. Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Chung, J.Y., Huang, C., Meng, X., Dong, Z., Yang, C.S. Cancer Res. (1999) [Pubmed]
  15. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. Lorenz, M., Wessler, S., Follmann, E., Michaelis, W., Düsterhöft, T., Baumann, G., Stangl, K., Stangl, V. J. Biol. Chem. (2004) [Pubmed]
  16. Growth inhibitory and antimetastatic effect of green tea polyphenols on metastasis-specific mouse mammary carcinoma 4T1 cells in vitro and in vivo systems. Baliga, M.S., Meleth, S., Katiyar, S.K. Clin. Cancer Res. (2005) [Pubmed]
  17. Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Masuda, M., Suzui, M., Weinstein, I.B. Clin. Cancer Res. (2001) [Pubmed]
  18. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Lee, W.J., Shim, J.Y., Zhu, B.T. Mol. Pharmacol. (2005) [Pubmed]
  19. Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. Nam, S., Smith, D.M., Dou, Q.P. J. Biol. Chem. (2001) [Pubmed]
  20. Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells. Syed, D.N., Afaq, F., Kweon, M.H., Hadi, N., Bhatia, N., Spiegelman, V.S., Mukhtar, H. Oncogene (2007) [Pubmed]
  21. Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis. Donà, M., Dell'Aica, I., Calabrese, F., Benelli, R., Morini, M., Albini, A., Garbisa, S. J. Immunol. (2003) [Pubmed]
  22. (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB. Lin, Y.L., Lin, J.K. Mol. Pharmacol. (1997) [Pubmed]
  23. Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression. El Bedoui, J., Oak, M.H., Anglard, P., Schini-Kerth, V.B. Cardiovasc. Res. (2005) [Pubmed]
  24. Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome. Murakami, N., Xie, W., Lu, R.C., Chen-Hwang, M.C., Wieraszko, A., Hwang, Y.W. J. Biol. Chem. (2006) [Pubmed]
  25. Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases. Sah, J.F., Balasubramanian, S., Eckert, R.L., Rorke, E.A. J. Biol. Chem. (2004) [Pubmed]
  26. Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Kang, T.H., Lee, J.H., Song, C.K., Han, H.D., Shin, B.C., Pai, S.I., Hung, C.F., Trimble, C., Lim, J.S., Kim, T.W., Wu, T.C. Cancer Res. (2007) [Pubmed]
  27. Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. Chow, H.H., Hakim, I.A., Vining, D.R., Crowell, J.A., Ranger-Moore, J., Chew, W.M., Celaya, C.A., Rodney, S.R., Hara, Y., Alberts, D.S. Clin. Cancer Res. (2005) [Pubmed]
  28. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Chen, C., Shen, G., Hebbar, V., Hu, R., Owuor, E.D., Kong, A.N. Carcinogenesis (2003) [Pubmed]
  29. Molecular targets for the cancer preventive activity of tea polyphenols. Yang, C.S., Lambert, J.D., Hou, Z., Ju, J., Lu, G., Hao, X. Mol. Carcinog. (2006) [Pubmed]
  30. Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice. Lambert, J.D., Lee, M.J., Lu, H., Meng, X., Hong, J.J., Seril, D.N., Sturgill, M.G., Yang, C.S. J. Nutr. (2003) [Pubmed]
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