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High impact information on Aspalathus

  • After the fractionation of rooibos tea infusion, the flavonoid fraction was found to be most anticlastogenic and antioxidative [1].
  • From these results we can conclude that antioxidant compounds in rooibos tea partially prevent oxidative stress and they are effective in both hydrophobic and hydrophilic biological systems [2].
  • Rooibos tea (Aspalathus linearis) partially prevents oxidative stress in streptozotocin-induced diabetic rats [2].
  • Administration of aqueous and alkaline extracts of rooibos tea (or N-acetyl-L-cysteine for comparison) to diabetic rats did not affect markers of the diabetic status (glucose, glycated hemoglobin and fructosamine) [2].
  • The modulating effect of ethanol/acetone (E/A) soluble fractions, prepared from methanolic extracts of processed and unprocessed rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) as well as green (Camellia sinensis) teas was established in a two-stage mouse skin carcinogenesis assay [3].

Biological context of Aspalathus

  • The processed leaves and stems of Aspalathus linearis contain a new diastereomeric pair of the flavanones, (S)- and (R)-eriodictyol-6-C-beta-D-glucopyranoside, which is also formed via the oxidative cyclization of the dihydrochalcone, aspalathin, under conditions which mimic the fermentation process [4].
  • Moreover, the reduction of OVA-induced antibody production in serum of the cyclosporin A (CyA) -treated rats can be significantly restored and the IL-2 generation in murine splenocytes was stimulated, following oral administrations of Rooibos tea extract [5].

Associations of Aspalathus with chemical compounds

  • Rooibos tea (Aspalathus linearis) was extracted by refluxing with water and 75% ethanol as a solvent [6].
  • Fermentation (i.e., oxidation) of rooibos decreased the pro-oxidant activity of aqueous extracts, which was contributed to a decrease in their dihydrochalcone content [7].
  • Besides the parameters characterizing hepatotoxic effect of streptozotocin, rooibos tea significantly lowered advanced glycation end-products (AGEs) and malondialdehyde (MDA) in the plasma and in different tissues of diabetic rats, particularly MDA concentration in the lens [2].
  • The TAA of unfermented rooibos (0.8 Trolox meq/g) resulted 2-fold higher than that of the fermented rooibos [8].
  • These changes resulted in a significant (P < 0.05) increase in the GSH/GSSG ratio by the unprocessed, processed rooibos and unprocessed honeybush teas [9].

Gene context of Aspalathus

  • Rooibos tea extract caused an increase in the generation of interleukin 2 (IL-2) both in OVA- and anti-CD3-primed splenocytes at concentrations ranging from 10 microg/ml to 1000 microg/ml [5].
  • Influence of processing stages on antimutagenic and antioxidant potentials of rooibos tea [10].
  • Rooibos tea contains a large amount of flavonoids and acts as a potent antioxidant [5].
  • Collectively, Rooibos tea intake may be of value in prophylaxis of the diseases involving a severe defect in Th1 immune response such as cancer, allergy, AIDS, and other infections [5].


  1. Radioprotective effects of antioxidative plant flavonoids in mice. Shimoi, K., Masuda, S., Shen, B., Furugori, M., Kinae, N. Mutat. Res. (1996) [Pubmed]
  2. Rooibos tea (Aspalathus linearis) partially prevents oxidative stress in streptozotocin-induced diabetic rats. Ulicná, O., Vancová, O., Bozek, P., Cársky, J., Sebeková, K., Boor, P., Nakano, M., Greksák, M. Physiological research / Academia Scientiarum Bohemoslovaca. (2006) [Pubmed]
  3. Inhibition of tumour promotion in mouse skin by extracts of rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia), unique South African herbal teas. Marnewick, J., Joubert, E., Joseph, S., Swanevelder, S., Swart, P., Gelderblom, W. Cancer Lett. (2005) [Pubmed]
  4. (S)- and (R)-eriodictyol-6-C-beta-D-glucopyranoside, novel keys to the fermentation of rooibos (Aspalathus linearis). Marais, C., van Rensburg, W.J., Ferreira, D., Steenkamp, J.A. Phytochemistry (2000) [Pubmed]
  5. Effects of rooibos tea extract on antigen-specific antibody production and cytokine generation in vitro and in vivo. Kunishiro, K., Tai, A., Yamamoto, I. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
  6. Antioxidant activity and protective effect on DNA strand scission of Rooibos tea (Aspalathus linearis). Lee, E.J., Jang, H.D. Biofactors (2004) [Pubmed]
  7. Antioxidant and pro-oxidant activities of aqueous extracts and crude polyphenolic fractions of rooibos (Aspalathus linearis). Joubert, E., Winterton, P., Britz, T.J., Gelderblom, W.C. J. Agric. Food Chem. (2005) [Pubmed]
  8. Unfermented rooibos tea: quantitative characterization of flavonoids by HPLC-UV and determination of the total antioxidant activity. Bramati, L., Aquilano, F., Pietta, P. J. Agric. Food Chem. (2003) [Pubmed]
  9. Modulation of hepatic drug metabolizing enzymes and oxidative status by rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), green and black (Camellia sinensis) teas in rats. Marnewick, J.L., Joubert, E., Swart, P., Van Der Westhuizen, F., Gelderblom, W.C. J. Agric. Food Chem. (2003) [Pubmed]
  10. Influence of processing stages on antimutagenic and antioxidant potentials of rooibos tea. Standley, L., Winterton, P., Marnewick, J.L., Gelderblom, W.C., Joubert, E., Britz, T.J. J. Agric. Food Chem. (2001) [Pubmed]
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