High impact information on Cyamopsis

• Guar gum in the treatment of NIDDM [1].
• Guar gum improved long-term glycemic control, postprandial glucose tolerance and lipid concentrations [2].
• Effect of tender cluster bean pods (Cyamopsis tetragonoloba) on cholesterol levels in rats [3].
• Guar also attenuated the postprandial rise in plasma triacylglycerols [4].
• Guar gum-based three-layer matrix tablets of a highly water-soluble drug, trimetazidine dihydrochloride, were evaluated for their in vivo release in healthy volunteers in comparison with commercially available conventional immediate release tablets [5].

Biological context of Cyamopsis

• DNA sequences from the nuclear ribosomal spacers of Ceratonia siliqua and Cyamopsis tetragonoloba, the plant sources of E-410 and E-412, respectively, were used to design polymerase chain reaction primers specific for each additive (PA23/PA21 and PG22/PG21) [6].

Anatomical context of Cyamopsis

• RESULTS: Guar gum matrix tablets released 4-18% sennosides in the physiological environment of gastrointestinal tract depending on the proportion of the guar gum used in the formulation [7].

Associations of Cyamopsis with chemical compounds

• Guar gum-based sustained release diltiazem [8].
• CONCLUSIONS: Guar gum, a galactomannan, which is 50 times cheaper than Difco-bacto agar, can be used as a gelling agent in place of agar in microbial culture media [9].
• The influence of Guar gum on absorption of metformin from the gut in healthy volunteers [10].
• Guar gum increased the activities of glucose-6-phosphate dehydrogenase, malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+), ATP-citrate (pro-3S)-lyase and 6-phosphofructokinase expressed on a liver-protein basis [11].
• Guar gum significantly reduced the net absorption of water from the glucose solution from 42.7 to 8.3% (P less than 0.01) and from the maltose solution from 49.2 to 5.1% (P less than 0.001) [12].

Gene context of Cyamopsis

• Guar ingestion reduced postprandial insulin and enteroglucagon responses, the latter significantly so, but had no apparent effect on gastric inhibitory polypeptide, pancreatic glucagon, gastrin, and pancreatic polypeptide [13].
• Guar also reduced plasma glucose concentrations after a test breakfast (p less than 0.05) and increased the response of neurotensin (p less than 0.05) [14].
• Guar gum bread significantly reduced the postprandial rise in blood glucose, plasma insulin, and, except for bread containing low MW guar gum, plasma GIP levels compared to the control [15].
• The methylotrophic yeast Hansenula polymorpha, a host organism for the production of heterologous proteins, has been applied to produce the alpha-galactosidase from the plant Cyamopsis tetragonoloba (guar) [16].
• Guar gum pasta may provide a simple dietary addition for the management of common metabolic disorders [17].

Analytical, diagnostic and therapeutic context of Cyamopsis

• CONCLUSIONS: Guar gum-enriched enteral nutrition was related to a decrease of diarrheal episodes in ICU patients with preexisting diarrhea; and to a trend for lower plasma glucose and cholesterol levels [18].

References