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Chemical Compound Review

Sennosides     9-[2-carboxy-4-hydroxy-10- oxo-5-[(2S,3R,4S...

Synonyms: sennoside, Sennoside G, Pursennid (TN), AC1LCVKW, CHEMBL448894, ...
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Disease relevance of Sennosides


High impact information on Sennosides


Biological context of Sennosides

  • Thus, sennosides and their natural metabolites specifically influence large intestinal motility [10].
  • After daily doses of 5 g of the senna laxative containing 15 mg sennosides for 3 days, the rhein concentration in milk samples from every lactation during 24 h post-dose varied between 0 and 27 ng/ml with values below 10 ng/ml in 94% [11].
  • The colour intensity of these products was approximately the same by weight as that of the sennosides themselves, although sennidins could no longer be freed from these by acid hydrolysis [12].
  • Effects of sennosides and nonanthranoid laxatives on cytochemistry of epithelial cells in rat colon [13].
  • The effects of sennosides on uterine motility were evaluated by electromyography in healthy adult ewes between day 70 and 120 of pregnancy to assess possible disturbances of the physiological pattern of contractility and eventual risks in pregnancy maintenance [14].

Anatomical context of Sennosides

  • A strictly anaerobic bacterium capable of metabolizing sennosides was isolated from human feces and identified as Bifidobacterium sp., named strain SEN [1].
  • Dual effect of orally administered sennosides on large intestine transit and fluid absorption in the rat [15].
  • Addition of rhein-Na, as one of the probable active metabolites of sennosides, into the bath medium of isolated colon and ileum segments of untreated rats showed a reduction in contractility at concentrations of more than 10(-5) and 10(-4) mol/l, respectively [16].
  • The alkali fusion method may be useful in connection with the isolation of as yet unknown metabolites of the sennosides in the gastrointestinal tract [12].
  • These results suggest that sennosides have a good intestinal mucosa tolerance as opposed to aglycosidic-related compounds [17].

Associations of Sennosides with other chemical compounds


Gene context of Sennosides

  • Cytokeratin AE1 expression increased on picosulfate and sennosides [13].
  • Rhein anthrone, the active metabolite of sennosides A and B, stimulated PGE2 release into the mouse colonic lumen [22].
  • A reversed-phase column liquid chromatographic method for the analysis of sennosides A and B present in leaf and pod extracts of Cassia angustifolia has been developed using a Symmetry C18 column and a linear binary gradient profile [23].

Analytical, diagnostic and therapeutic context of Sennosides

  • The effects of sennosides on colonic motility were investigated in eight conscious dogs chronically fitted with two strain gauge transducers in the proximal colon, an intracolonic silicone catheter and a polyethylene catheter implanted in a branch of the right colonic artery [24].
  • Forced decomposition of this herbal drug preparation under high temperature caused oxidative decomposition of the sennosides to rhein 8-O-glucoside [25].
  • Oral administration of sennosides (20-30 mg/kg) to fasted dogs has been shown to induce a strong and long-lasting inhibition of myoelectric colon activity which was evident after a delay of 6-10 h corresponding to oro-cecal transit and colonic metabolism and was accompanied by abundant diarrhea [26].
  • Validated HPLC method for determination of sennosides A and B in senna tablets [27].
  • Analytical studies on the active constituents in crude drugs. IV. Determination of sennosides in senna and formulations by high-performance liquid chromatography [28].


  1. Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins. Akao, T., Che, Q.M., Kobashi, K., Yang, L., Hattori, M., Namba, T. Appl. Environ. Microbiol. (1994) [Pubmed]
  2. Electron microscopical studies on rat intestine after long-term treatment with sennosides. Rudolph, R.L., Mengs, U. Pharmacology (1988) [Pubmed]
  3. The effect of raw material purity on the acute toxicity and laxative effect of sennosides. Marvola, M., Koponen, A., Hiltunen, R., Hieltala, P. J. Pharm. Pharmacol. (1981) [Pubmed]
  4. Chronic sennoside treatment does not cause habituation and secondary hyperaldosteronism in rats. Leng-Peschlow, E., Odenthal, K.P., Voderholzer, W., Müller-Lissner, S. Pharmacology (1993) [Pubmed]
  5. The effect of sennosides on bacterial translocation and survival in a model of acute hemorrhagic pancreatitis. Chen, X., Valente, J.F., Alexander, J.W. Pancreas (1999) [Pubmed]
  6. Apoptosis induction by sennoside laxatives in man; escape from a protective mechanism during chronic sennoside use? van Gorkom, B.A., Karrenbeld, A., van der Sluis, T., Zwart, N., de Vries, E.G., Kleibeuker, J.H. J. Pathol. (2001) [Pubmed]
  7. Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2). Laitinen, L., Takala, E., Vuorela, H., Vuorela, P., Kaukonen, A.M., Marvola, M. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V (2007) [Pubmed]
  8. Influence of a highly purified senna extract on colonic epithelium. van Gorkom, B.A., Karrenbeld, A., van Der Sluis, T., Koudstaal, J., de Vries, E.G., Kleibeuker, J.H. Digestion (2000) [Pubmed]
  9. Genotoxicity of sennosides on the bone marrow cells of mice. Mukhopadhyay, M.J., Saha, A., Dutta, A., De, B., Mukherjee, A. Food Chem. Toxicol. (1998) [Pubmed]
  10. Acceleration of large intestine transit time in rats by sennosides and related compounds. Leng-Peschlow, E. J. Pharm. Pharmacol. (1986) [Pubmed]
  11. Relevance of rhein excretion into breast milk. Faber, P., Strenge-Hesse, A. Pharmacology (1988) [Pubmed]
  12. New aspects on the metabolism of the sennosides. Hietala, P., Lainonen, H., Marvola, M. Pharmacology (1988) [Pubmed]
  13. Effects of sennosides and nonanthranoid laxatives on cytochemistry of epithelial cells in rat colon. Yang, K., Fan, K., Mengs, U., Lipkin, M. Pharmacology (1993) [Pubmed]
  14. Evaluation of the effects of sennosides on uterine motility in the pregnant ewe. Garcia-Villar, R. Pharmacology (1988) [Pubmed]
  15. Dual effect of orally administered sennosides on large intestine transit and fluid absorption in the rat. Leng-Peschlow, E. J. Pharm. Pharmacol. (1986) [Pubmed]
  16. In vitro effects of anthraquinones on rat intestine and uterus. Odenthal, K.P., Ziegler, D. Pharmacology (1988) [Pubmed]
  17. Long-term mucosal alterations by sennosides and related compounds. Dufour, P., Gendre, P. Pharmacology (1988) [Pubmed]
  18. Light and electron-microscopic changes in the colon of the guinea pig after treatment with anthranoid and non-anthranoid laxatives. Mengs, U., Rudolph, R.L. Pharmacology (1993) [Pubmed]
  19. Effects of 'contact laxatives' on intestinal and colonic epithelial cell proliferation. Geboes, K., Nijs, G., Mengs, U., Geboes, K.P., Van Damme, A., de Witte, P. Pharmacology (1993) [Pubmed]
  20. Effect of sennosides and related compounds on intestinal transit in the rat. Leng-Peschlow, E. Pharmacology (1988) [Pubmed]
  21. Sennoside-induced secretion is not caused by changes in mucosal permeability or Na+,K(+)-ATPase activity. Leng-Peschlow, E. J. Pharm. Pharmacol. (1993) [Pubmed]
  22. Prostaglandin E2-mediated stimulation of mucus synthesis and secretion by rhein anthrone, the active metabolite of sennosides A and B, in the mouse colon. Yagi, T., Miyawaki, Y., Nishikawa, A., Horiyama, S., Yamauchi, K., Kuwano, S. J. Pharm. Pharmacol. (1990) [Pubmed]
  23. An improved method for the analysis of sennosides in Cassia angustifolia by high-performance liquid chromatography. Bala, S., Uniyal, G.C., Dubey, T., Singh, S.P. Phytochemical analysis : PCA. (2001) [Pubmed]
  24. Changes in colonic motility induced by sennosides in dogs: evidence of a prostaglandin mediation. Staumont, G., Fioramonti, J., Frexinos, J., Bueno, L. Gut (1988) [Pubmed]
  25. Stability control of senna leaves and senna extracts. Goppel, M., Franz, G. Planta Med. (2004) [Pubmed]
  26. Effect of sennosides on colon motility in dogs. Fioramonti, J., Staumont, G., Garcia-Villar, R., Buéno, L. Pharmacology (1988) [Pubmed]
  27. Validated HPLC method for determination of sennosides A and B in senna tablets. Sun, S.W., Su, H.T. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  28. Analytical studies on the active constituents in crude drugs. IV. Determination of sennosides in senna and formulations by high-performance liquid chromatography. Hayashi, S., Yoshida, A., Tanaka, H., Mitani, Y., Yoshizawa, K. Chem. Pharm. Bull. (1980) [Pubmed]
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