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MeSH Review


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High impact information on Coleus

  • Forskolin is a diterpene derivative of the plant Coleus forskohlii that stimulates adenylate cyclase activity without interacting with cell surface receptors [1].
  • Forskolin (7 beta-acetoxy-8,13-epoxy-1 alpha, 6 beta, 9 alpha-trihydroxylabd-14-en-11-one), a diterpene from the Indian plant Coleus forskohlii, activates cyclic AMP generating systems in a number of mammalian tissues in a rapid and reversible fashion [2].
  • The HPPR protein was purified from suspension cells of Coleus blumei accumulating high levels of rosmarinic acid by ammonium sulfate precipitation, anion exchange chromatography, hydroxylapatite chromatography, chromatography on 2',5'-ADP-Sepharose 4B and SDS-polyacrylamide gel electrophoresis [3].
  • Preliminary studies of ascorbate metabolism in green and albino regions of variegated leaves of Coleus blumei, Benth [4].
  • Green and white variegated leaves of Coleus blumei, Benth. were separated into albino and green sections and used to determine the distribution of vitamin C and L-galactose dehydrogenase activity, an enzyme supposed to be involved in ascorbate metabolism, in heterotrophic and autotrophic foliar fractions [4].

Biological context of Coleus


Anatomical context of Coleus


Associations of Coleus with chemical compounds

  • Stigmasterol from Coleus forskohlii and ecdysterone from Diploclisia glaucescens were inactive constituents isolated during the process of purifying the active principles of the plants [7].
  • Abietane diterpenoids from Coleus xanthanthus [8].
  • Coleus forskohlii hairy root cultures were shown to biotransform methanol and ethanol to the corresponding beta-D-glucopyranosides and beta-D-ribo-hex-3-ulopyranosides, and 2-propanol to its beta-D-glucopyranoside [9].
  • Eight new abietane diterpenoids, coleon U 11-acetate (1), 16-acetoxycoleon U 11-acetate (2), and xanthanthusins F-K (3-8), together with five known analogues, coleon U (9), 16-O-acetylcoleon C (10), coleon U-quinone (11), 8alpha,9alpha-epoxycoleon U-quinone (12), and xanthanthusin E (13), were isolated from the aerial parts of Coleus xanthanthus [8].
  • Cytochemical localization of phenol-oxidizing enzymes in lignifying Coleus blumei stems [10].

Analytical, diagnostic and therapeutic context of Coleus


  1. Forskolin lowers intraocular pressure by reducing aqueous inflow. Caprioli, J., Sears, M., Bausher, L., Gregory, D., Mead, A. Invest. Ophthalmol. Vis. Sci. (1984) [Pubmed]
  2. Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. Seamon, K.B., Daly, J.W., Metzger, H., de Souza, N.J., Reden, J. J. Med. Chem. (1983) [Pubmed]
  3. Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei. Kim, K.H., Janiak, V., Petersen, M. Plant Mol. Biol. (2004) [Pubmed]
  4. Preliminary studies of ascorbate metabolism in green and albino regions of variegated leaves of Coleus blumei, Benth. Peltzer, D., Schwanz, P., Polle, A. Free Radic. Res. (1999) [Pubmed]
  5. The effect of chronic in vivo infusion of forskolin on noradrenergic receptor sensitivity. Suzdak, P.D., Browne, R.G. Psychopharmacology (Berl.) (1985) [Pubmed]
  6. Efficiency of Coleus aromaticus extract in modifying cyclophosphamide and mitomycin-C induced clastogenicity in mouse bone marrow cells. Prasad, S., Naik, P., Vijayalaxmi, K.K. Indian J. Exp. Biol. (2002) [Pubmed]
  7. Chonemorphine, stigmasterol, and ecdysterone: steroids isolated through bioassay-directed plant screening programs. Shah, V.C., D'Sa, A.S., de Souza, N.J. Steroids (1989) [Pubmed]
  8. Abietane diterpenoids from Coleus xanthanthus. Mei, S.X., Jiang, B., Niu, X.M., Li, M.L., Yang, H., Na, Z., Lin, Z.W., Li, C.M., Sun, H.D. J. Nat. Prod. (2002) [Pubmed]
  9. Biotransformation of low-molecular-weight alcohols by Coleus forskohlii hairy root cultures. Li, W., Koike, K., Asada, Y., Yoshikawa, T., Nikaido, T. Carbohydr. Res. (2003) [Pubmed]
  10. Cytochemical localization of phenol-oxidizing enzymes in lignifying Coleus blumei stems. de Pinto, M.C., Ros Barceló, A. European journal of histochemistry : EJH. (1997) [Pubmed]
  11. Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq. Engprasert, S., Taura, F., Kawamukai, M., Shoyama, Y. BMC Plant Biol. (2004) [Pubmed]
  12. Production of lepidimoide by an endophytic fungus from polysaccharide extracted from Abelmoschus sp.: identification of the product and the organism producing it. Tanaka, M., Yoshimura, M., Suto, M., Yokota, A., Asano, K., Sukara, E., Tomita, F. J. Biosci. Bioeng. (2002) [Pubmed]
  13. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. al-Sereiti, M.R., Abu-Amer, K.M., Sen, P. Indian J. Exp. Biol. (1999) [Pubmed]
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