High impact information on Coleus

• Forskolin is a diterpene derivative of the plant Coleus forskohlii that stimulates adenylate cyclase activity without interacting with cell surface receptors [1].
• Forskolin (7 beta-acetoxy-8,13-epoxy-1 alpha, 6 beta, 9 alpha-trihydroxylabd-14-en-11-one), a diterpene from the Indian plant Coleus forskohlii, activates cyclic AMP generating systems in a number of mammalian tissues in a rapid and reversible fashion [2].
• The HPPR protein was purified from suspension cells of Coleus blumei accumulating high levels of rosmarinic acid by ammonium sulfate precipitation, anion exchange chromatography, hydroxylapatite chromatography, chromatography on 2',5'-ADP-Sepharose 4B and SDS-polyacrylamide gel electrophoresis [3].
• Preliminary studies of ascorbate metabolism in green and albino regions of variegated leaves of Coleus blumei, Benth [4].
• Green and white variegated leaves of Coleus blumei, Benth. were separated into albino and green sections and used to determine the distribution of vitamin C and L-galactose dehydrogenase activity, an enzyme supposed to be involved in ascorbate metabolism, in heterotrophic and autotrophic foliar fractions [4].

Biological context of Coleus

• Forskolin, a diterpene isolated from the plant Coleus forskolii, activates the catalytic subunit of adenylate cyclase, resulting in a hormone receptor-independent increase in the intracellular production of cyclic AMP [5].

Anatomical context of Coleus

• Efficiency of Coleus aromaticus extract in modifying cyclophosphamide and mitomycin-C induced clastogenicity in mouse bone marrow cells [6].

Associations of Coleus with chemical compounds

• Stigmasterol from Coleus forskohlii and ecdysterone from Diploclisia glaucescens were inactive constituents isolated during the process of purifying the active principles of the plants [7].
• Abietane diterpenoids from Coleus xanthanthus [8].
• Coleus forskohlii hairy root cultures were shown to biotransform methanol and ethanol to the corresponding beta-D-glucopyranosides and beta-D-ribo-hex-3-ulopyranosides, and 2-propanol to its beta-D-glucopyranoside [9].
• Eight new abietane diterpenoids, coleon U 11-acetate (1), 16-acetoxycoleon U 11-acetate (2), and xanthanthusins F-K (3-8), together with five known analogues, coleon U (9), 16-O-acetylcoleon C (10), coleon U-quinone (11), 8alpha,9alpha-epoxycoleon U-quinone (12), and xanthanthusin E (13), were isolated from the aerial parts of Coleus xanthanthus [8].
• Cytochemical localization of phenol-oxidizing enzymes in lignifying Coleus blumei stems [10].

Analytical, diagnostic and therapeutic context of Coleus

• Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq [11].
• We discovered an endophytic fungal strain AHU9748 isolated from Coleus galeatus, which produced an oligosaccharide having similar properties to lepidimoide on thin layer chromatography [12].
• Relatively large-scale production of rosmarinic acid can be obtained from the cell culture of Coleus blumei Benth when supplied exogenously with phenylalanine and tyrosine [13].

References